Coffee Consumption and Cystatin-C-Based Estimated Glomerular Filtration Rates in Healthy Young Adults: Results of a Clinical Trial

Recently it has been reported that the estimated glomerular filtration rate (eGFR) is higher in habitual coffee consumers than in noncoffee consumers. However, the causality remains unclear. Therefore, we conducted a clinical trial to investigate the effects of coffee consumption on kidney function....

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Main Authors: Masafumi Saito, Tohru Nemoto, Satoshi Tobimatsu, Midori Ebata, Yulan Le, Kei Nakajima
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:Journal of Nutrition and Metabolism
Online Access:http://dx.doi.org/10.1155/2011/146865
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author Masafumi Saito
Tohru Nemoto
Satoshi Tobimatsu
Midori Ebata
Yulan Le
Kei Nakajima
author_facet Masafumi Saito
Tohru Nemoto
Satoshi Tobimatsu
Midori Ebata
Yulan Le
Kei Nakajima
author_sort Masafumi Saito
collection DOAJ
description Recently it has been reported that the estimated glomerular filtration rate (eGFR) is higher in habitual coffee consumers than in noncoffee consumers. However, the causality remains unclear. Therefore, we conducted a clinical trial to investigate the effects of coffee consumption on kidney function. Nineteen asymptomatic nonsmokers aged 21–27 years old participated in this study. They consumed coffee (18 g coffee beans/450 mL per day) or green tea as a comparator for 2 weeks in a crossover design. Although creatinine-based eGFR was not affected after consuming either beverage, all cystatin-C-based eGFRs determined using five different equations were significantly increased after coffee consumption (means: 5.0–7.7%), but not after green tea consumption (means: 0.1–1.6%). Serum adiponectin and magnesium levels increased significantly after coffee consumption (means: 13.6% and 4.3%, resp.), but not after green tea consumption. These findings suggest that even a short period of coffee consumption may increase cystatin-C-based eGFR, along with favorable changes in serum adiponectin, in healthy young adults.
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spelling doaj-art-81508d74a09c42d3bd5b8d6a8119e33b2025-08-20T02:08:50ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322011-01-01201110.1155/2011/146865146865Coffee Consumption and Cystatin-C-Based Estimated Glomerular Filtration Rates in Healthy Young Adults: Results of a Clinical TrialMasafumi Saito0Tohru Nemoto1Satoshi Tobimatsu2Midori Ebata3Yulan Le4Kei Nakajima5Division of Clinical Nutrition, Department of Medical Dietetics, Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, JapanDivision of Clinical Nutrition, Department of Medical Dietetics, Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, JapanDivision of Clinical Nutrition, Department of Medical Dietetics, Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, JapanDivision of Clinical Nutrition, Department of Medical Dietetics, Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, JapanDivision of Clinical Nutrition, Department of Medical Dietetics, Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, JapanDivision of Clinical Nutrition, Department of Medical Dietetics, Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, JapanRecently it has been reported that the estimated glomerular filtration rate (eGFR) is higher in habitual coffee consumers than in noncoffee consumers. However, the causality remains unclear. Therefore, we conducted a clinical trial to investigate the effects of coffee consumption on kidney function. Nineteen asymptomatic nonsmokers aged 21–27 years old participated in this study. They consumed coffee (18 g coffee beans/450 mL per day) or green tea as a comparator for 2 weeks in a crossover design. Although creatinine-based eGFR was not affected after consuming either beverage, all cystatin-C-based eGFRs determined using five different equations were significantly increased after coffee consumption (means: 5.0–7.7%), but not after green tea consumption (means: 0.1–1.6%). Serum adiponectin and magnesium levels increased significantly after coffee consumption (means: 13.6% and 4.3%, resp.), but not after green tea consumption. These findings suggest that even a short period of coffee consumption may increase cystatin-C-based eGFR, along with favorable changes in serum adiponectin, in healthy young adults.http://dx.doi.org/10.1155/2011/146865
spellingShingle Masafumi Saito
Tohru Nemoto
Satoshi Tobimatsu
Midori Ebata
Yulan Le
Kei Nakajima
Coffee Consumption and Cystatin-C-Based Estimated Glomerular Filtration Rates in Healthy Young Adults: Results of a Clinical Trial
Journal of Nutrition and Metabolism
title Coffee Consumption and Cystatin-C-Based Estimated Glomerular Filtration Rates in Healthy Young Adults: Results of a Clinical Trial
title_full Coffee Consumption and Cystatin-C-Based Estimated Glomerular Filtration Rates in Healthy Young Adults: Results of a Clinical Trial
title_fullStr Coffee Consumption and Cystatin-C-Based Estimated Glomerular Filtration Rates in Healthy Young Adults: Results of a Clinical Trial
title_full_unstemmed Coffee Consumption and Cystatin-C-Based Estimated Glomerular Filtration Rates in Healthy Young Adults: Results of a Clinical Trial
title_short Coffee Consumption and Cystatin-C-Based Estimated Glomerular Filtration Rates in Healthy Young Adults: Results of a Clinical Trial
title_sort coffee consumption and cystatin c based estimated glomerular filtration rates in healthy young adults results of a clinical trial
url http://dx.doi.org/10.1155/2011/146865
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