Efficacy and safety of nimesulide long term administration in patients with osteoarthritis: results of 12-months open controlled study DINAMO (long term administration of nimesulide in osteoarthritis multifactor assessment)
Objective. To compare efficacy and safety of nimesulide and paracetamol in treatment of patients with osteoarthritis (OA) during 12 months. Material and methods. 40 women (mean age 66,8±5,1 years) with knee osteoarthritis (II-III stage according to Kellgren-Lawrence) having intensive pain (>4...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2009-08-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/1066 |
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| author | L I Alexeeva A E Karateev T V Popkova D S Novikova E N Sharapova E P Markelova E L Nasonov |
| author_facet | L I Alexeeva A E Karateev T V Popkova D S Novikova E N Sharapova E P Markelova E L Nasonov |
| author_sort | L I Alexeeva |
| collection | DOAJ |
| description | Objective. To compare efficacy and safety of nimesulide and paracetamol in treatment of patients with osteoarthritis (OA) during 12 months. Material and methods. 40 women (mean age 66,8±5,1 years) with knee osteoarthritis (II-III stage according to Kellgren-Lawrence) having intensive pain (>40 mm on VAS) were included. Group 1 pts (n=20) received nimesulide 200-100 mg/day. Group 2 pts were treated with paracetamol till 3 g/day. WOMAC was used as efficacy measure. Safety was assessed with endoscopic examination of upper gastrointestinal tract, ECG, blood pressure and ECG Holter monitoring, clinical and biochemical blood parameters. Statistical significance of differences was assessed with Student’s t-test, χ2 and Fisher exact test Results. WOMAC index decreased during treatment from 1182,7±345,9 to 698,4±351,1 for nimesulide and from 1136,4±313,8 to 1031,6±21 for paracetamol (p<0,05). There were 6 cases of gastrointestinal complications and 4 cases of hypertension development or deterioration in each group. Coronary heart disease developed or deteriorated in 4 patients receiving nimesulide but not in control group. Liver function tests did not deteriorated during treatment with nimesulide. Conclusion. Nimesulide was more effective than paracetamol in treatment of OA. But risk of cardiovascular complications development during treatment with NSAIDs requires serious attention. Nimesulide did not induced liver damage during long term treatment. |
| format | Article |
| id | doaj-art-814d839a7d8a40819ffec543da2a562e |
| institution | Kabale University |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2009-08-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj-art-814d839a7d8a40819ffec543da2a562e2025-08-20T04:00:41ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922009-08-01474647210.14412/1995-4484-2009-11521006Efficacy and safety of nimesulide long term administration in patients with osteoarthritis: results of 12-months open controlled study DINAMO (long term administration of nimesulide in osteoarthritis multifactor assessment)L I AlexeevaA E KarateevT V PopkovaD S NovikovaE N SharapovaE P MarkelovaE L NasonovObjective. To compare efficacy and safety of nimesulide and paracetamol in treatment of patients with osteoarthritis (OA) during 12 months. Material and methods. 40 women (mean age 66,8±5,1 years) with knee osteoarthritis (II-III stage according to Kellgren-Lawrence) having intensive pain (>40 mm on VAS) were included. Group 1 pts (n=20) received nimesulide 200-100 mg/day. Group 2 pts were treated with paracetamol till 3 g/day. WOMAC was used as efficacy measure. Safety was assessed with endoscopic examination of upper gastrointestinal tract, ECG, blood pressure and ECG Holter monitoring, clinical and biochemical blood parameters. Statistical significance of differences was assessed with Student’s t-test, χ2 and Fisher exact test Results. WOMAC index decreased during treatment from 1182,7±345,9 to 698,4±351,1 for nimesulide and from 1136,4±313,8 to 1031,6±21 for paracetamol (p<0,05). There were 6 cases of gastrointestinal complications and 4 cases of hypertension development or deterioration in each group. Coronary heart disease developed or deteriorated in 4 patients receiving nimesulide but not in control group. Liver function tests did not deteriorated during treatment with nimesulide. Conclusion. Nimesulide was more effective than paracetamol in treatment of OA. But risk of cardiovascular complications development during treatment with NSAIDs requires serious attention. Nimesulide did not induced liver damage during long term treatment.https://rsp.mediar-press.net/rsp/article/view/1066osteoarthritisnimesulideparacetamolnsaid-gastropathy |
| spellingShingle | L I Alexeeva A E Karateev T V Popkova D S Novikova E N Sharapova E P Markelova E L Nasonov Efficacy and safety of nimesulide long term administration in patients with osteoarthritis: results of 12-months open controlled study DINAMO (long term administration of nimesulide in osteoarthritis multifactor assessment) Научно-практическая ревматология osteoarthritis nimesulide paracetamol nsaid-gastropathy |
| title | Efficacy and safety of nimesulide long term administration in patients with osteoarthritis: results of 12-months open controlled study DINAMO (long term administration of nimesulide in osteoarthritis multifactor assessment) |
| title_full | Efficacy and safety of nimesulide long term administration in patients with osteoarthritis: results of 12-months open controlled study DINAMO (long term administration of nimesulide in osteoarthritis multifactor assessment) |
| title_fullStr | Efficacy and safety of nimesulide long term administration in patients with osteoarthritis: results of 12-months open controlled study DINAMO (long term administration of nimesulide in osteoarthritis multifactor assessment) |
| title_full_unstemmed | Efficacy and safety of nimesulide long term administration in patients with osteoarthritis: results of 12-months open controlled study DINAMO (long term administration of nimesulide in osteoarthritis multifactor assessment) |
| title_short | Efficacy and safety of nimesulide long term administration in patients with osteoarthritis: results of 12-months open controlled study DINAMO (long term administration of nimesulide in osteoarthritis multifactor assessment) |
| title_sort | efficacy and safety of nimesulide long term administration in patients with osteoarthritis results of 12 months open controlled study dinamo long term administration of nimesulide in osteoarthritis multifactor assessment |
| topic | osteoarthritis nimesulide paracetamol nsaid-gastropathy |
| url | https://rsp.mediar-press.net/rsp/article/view/1066 |
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