Exploring the application of dietary antioxidant index for disease risk assessment: a comprehensive review
Oxidative stress contributes to the development of cardiometabolic diseases and cancers. Numerous studies have highlighted the adverse effects of high reactive oxygen species (ROS) levels in the progression of chronic noncommunicable diseases and also during infections. On the other hand, antioxidan...
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| Format: | Article |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1497364/full |
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| author | Hossein Pourmontaseri Sina Bazmi Matin Sepehrinia Matin Sepehrinia Ayda Mostafavi Reza Arefnezhad Reza Arefnezhad Reza Homayounfar Farhad Vahid |
| author_facet | Hossein Pourmontaseri Sina Bazmi Matin Sepehrinia Matin Sepehrinia Ayda Mostafavi Reza Arefnezhad Reza Arefnezhad Reza Homayounfar Farhad Vahid |
| author_sort | Hossein Pourmontaseri |
| collection | DOAJ |
| description | Oxidative stress contributes to the development of cardiometabolic diseases and cancers. Numerous studies have highlighted the adverse effects of high reactive oxygen species (ROS) levels in the progression of chronic noncommunicable diseases and also during infections. On the other hand, antioxidants play a crucial role in preventing oxidative stress or postponing cell damage via the direct scavenging of free radicals or indirectly via the Keap1/Nrf2/ARE pathway, among others. Dietary antioxidants can be obtained from various sources, mainly through a plant-based diet, including fruits and vegetables. The dietary antioxidant index (DAI) has been developed to assess total antioxidant intake from diet. This review delineated the performance of DAI in the risk assessment of different diseases. It is suggested that a high DAI score prevents obesity-related diseases, including diabetes mellitus, hyperuricemia, dyslipidemia, and metabolic (dysfunction)-associated steatotic liver disease (MASLD). Additionally, DAI is negatively associated with Helicobacter pylori and Human papillomavirus infection, thus reducing the risk of gastric and cervical cancer. Also, a high intake of antioxidants prevents the development of osteoporosis, miscarriage, infertility, and mental illnesses. However, further prospective observations and clinical trials are warranted to confirm the application of DAI in preventing diseases that have been studied. |
| format | Article |
| id | doaj-art-814cb48697624d0581e9656a1350b694 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-814cb48697624d0581e9656a1350b6942025-01-16T16:04:55ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011110.3389/fnut.2024.14973641497364Exploring the application of dietary antioxidant index for disease risk assessment: a comprehensive reviewHossein Pourmontaseri0Sina Bazmi1Matin Sepehrinia2Matin Sepehrinia3Ayda Mostafavi4Reza Arefnezhad5Reza Arefnezhad6Reza Homayounfar7Farhad Vahid8Student Research Committee, Fasa University of Medical Sciences, Fasa, IranStudent Research Committee, Fasa University of Medical Sciences, Fasa, IranStudent Research Committee, Fasa University of Medical Sciences, Fasa, IranNoncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, IranDepartment of Psychology, Panjab University, Chandigarh, IndiaCoenzyme R Research Institute, Tehran, IranStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, IranNational Nutrition and Food Technology Research Institute (WHO Collaborating Center), Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, IranNutrition and Health Research Group, Department of Precision Health, Luxembourg Institute of Health, Strassen, LuxembourgOxidative stress contributes to the development of cardiometabolic diseases and cancers. Numerous studies have highlighted the adverse effects of high reactive oxygen species (ROS) levels in the progression of chronic noncommunicable diseases and also during infections. On the other hand, antioxidants play a crucial role in preventing oxidative stress or postponing cell damage via the direct scavenging of free radicals or indirectly via the Keap1/Nrf2/ARE pathway, among others. Dietary antioxidants can be obtained from various sources, mainly through a plant-based diet, including fruits and vegetables. The dietary antioxidant index (DAI) has been developed to assess total antioxidant intake from diet. This review delineated the performance of DAI in the risk assessment of different diseases. It is suggested that a high DAI score prevents obesity-related diseases, including diabetes mellitus, hyperuricemia, dyslipidemia, and metabolic (dysfunction)-associated steatotic liver disease (MASLD). Additionally, DAI is negatively associated with Helicobacter pylori and Human papillomavirus infection, thus reducing the risk of gastric and cervical cancer. Also, a high intake of antioxidants prevents the development of osteoporosis, miscarriage, infertility, and mental illnesses. However, further prospective observations and clinical trials are warranted to confirm the application of DAI in preventing diseases that have been studied.https://www.frontiersin.org/articles/10.3389/fnut.2024.1497364/fullmetabolic diseasemental disorderscardiovascular diseasescancerosteoporosisinfertility |
| spellingShingle | Hossein Pourmontaseri Sina Bazmi Matin Sepehrinia Matin Sepehrinia Ayda Mostafavi Reza Arefnezhad Reza Arefnezhad Reza Homayounfar Farhad Vahid Exploring the application of dietary antioxidant index for disease risk assessment: a comprehensive review Frontiers in Nutrition metabolic disease mental disorders cardiovascular diseases cancer osteoporosis infertility |
| title | Exploring the application of dietary antioxidant index for disease risk assessment: a comprehensive review |
| title_full | Exploring the application of dietary antioxidant index for disease risk assessment: a comprehensive review |
| title_fullStr | Exploring the application of dietary antioxidant index for disease risk assessment: a comprehensive review |
| title_full_unstemmed | Exploring the application of dietary antioxidant index for disease risk assessment: a comprehensive review |
| title_short | Exploring the application of dietary antioxidant index for disease risk assessment: a comprehensive review |
| title_sort | exploring the application of dietary antioxidant index for disease risk assessment a comprehensive review |
| topic | metabolic disease mental disorders cardiovascular diseases cancer osteoporosis infertility |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1497364/full |
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