Dynamic evolution of bone marrow adipocyte in B cell acute lymphoblastic leukemia: insights from diagnosis to post-chemotherapy
Adipocyte is a unique and versatile component of bone marrow microenvironment (BMM). However, the dynamic evolution of Bone Marrow (BM) adipocytes from the diagnosis of B cell Acute Lymphoblastic Leukemia (B-ALL) to the post-treatment state, and how they affect the progression of leukemia, remains i...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Cancer Biology & Therapy |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15384047.2024.2323765 |
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| author | Xi Jia Naying Liao Yunqian Yao Xutao Guo Kai Chen Pengcheng Shi |
| author_facet | Xi Jia Naying Liao Yunqian Yao Xutao Guo Kai Chen Pengcheng Shi |
| author_sort | Xi Jia |
| collection | DOAJ |
| description | Adipocyte is a unique and versatile component of bone marrow microenvironment (BMM). However, the dynamic evolution of Bone Marrow (BM) adipocytes from the diagnosis of B cell Acute Lymphoblastic Leukemia (B-ALL) to the post-treatment state, and how they affect the progression of leukemia, remains inadequately explicated. Primary patient-derived xenograft models (PDXs) and stromal cell co-culture system are employed in this study. We show that the dynamic evolution of BM adipocytes from initial diagnosis of B-ALL to the post-chemotherapy phase, transitioning from cellular depletion in the initial leukemia niche to a fully restored state upon remission. Increased BM adipocytes retards engraftment of B-ALL cells in PDX models and inhibits cells growth of B-ALL in vitro. Mechanistically, the proliferation arrest of B-ALL cells in the context of adipocytes-enrichment niche, might attribute to the presence of adiponectin secreted by adipocytes themselves and the absence of cytokines secreted by mesenchymal stem cell (MSCs). In summary, our findings offer a novel perspective for further in-depth understanding of the dynamic balance between BMM and B-ALL. |
| format | Article |
| id | doaj-art-812a72e9fc0e4276bee87208c1490fef |
| institution | DOAJ |
| issn | 1538-4047 1555-8576 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cancer Biology & Therapy |
| spelling | doaj-art-812a72e9fc0e4276bee87208c1490fef2025-08-20T02:49:46ZengTaylor & Francis GroupCancer Biology & Therapy1538-40471555-85762024-12-0125110.1080/15384047.2024.2323765Dynamic evolution of bone marrow adipocyte in B cell acute lymphoblastic leukemia: insights from diagnosis to post-chemotherapyXi Jia0Naying Liao1Yunqian Yao2Xutao Guo3Kai Chen4Pengcheng Shi5Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. ChinaDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. ChinaDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. ChinaDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. ChinaDepartment of Radiotherapy, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. ChinaAdipocyte is a unique and versatile component of bone marrow microenvironment (BMM). However, the dynamic evolution of Bone Marrow (BM) adipocytes from the diagnosis of B cell Acute Lymphoblastic Leukemia (B-ALL) to the post-treatment state, and how they affect the progression of leukemia, remains inadequately explicated. Primary patient-derived xenograft models (PDXs) and stromal cell co-culture system are employed in this study. We show that the dynamic evolution of BM adipocytes from initial diagnosis of B-ALL to the post-chemotherapy phase, transitioning from cellular depletion in the initial leukemia niche to a fully restored state upon remission. Increased BM adipocytes retards engraftment of B-ALL cells in PDX models and inhibits cells growth of B-ALL in vitro. Mechanistically, the proliferation arrest of B-ALL cells in the context of adipocytes-enrichment niche, might attribute to the presence of adiponectin secreted by adipocytes themselves and the absence of cytokines secreted by mesenchymal stem cell (MSCs). In summary, our findings offer a novel perspective for further in-depth understanding of the dynamic balance between BMM and B-ALL.https://www.tandfonline.com/doi/10.1080/15384047.2024.2323765Acutelymphoblasticleukemiabonemarrowmicroenvironment |
| spellingShingle | Xi Jia Naying Liao Yunqian Yao Xutao Guo Kai Chen Pengcheng Shi Dynamic evolution of bone marrow adipocyte in B cell acute lymphoblastic leukemia: insights from diagnosis to post-chemotherapy Cancer Biology & Therapy Acute lymphoblastic leukemia bone marrow microenvironment |
| title | Dynamic evolution of bone marrow adipocyte in B cell acute lymphoblastic leukemia: insights from diagnosis to post-chemotherapy |
| title_full | Dynamic evolution of bone marrow adipocyte in B cell acute lymphoblastic leukemia: insights from diagnosis to post-chemotherapy |
| title_fullStr | Dynamic evolution of bone marrow adipocyte in B cell acute lymphoblastic leukemia: insights from diagnosis to post-chemotherapy |
| title_full_unstemmed | Dynamic evolution of bone marrow adipocyte in B cell acute lymphoblastic leukemia: insights from diagnosis to post-chemotherapy |
| title_short | Dynamic evolution of bone marrow adipocyte in B cell acute lymphoblastic leukemia: insights from diagnosis to post-chemotherapy |
| title_sort | dynamic evolution of bone marrow adipocyte in b cell acute lymphoblastic leukemia insights from diagnosis to post chemotherapy |
| topic | Acute lymphoblastic leukemia bone marrow microenvironment |
| url | https://www.tandfonline.com/doi/10.1080/15384047.2024.2323765 |
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