Evidence that the human cell cycle is a series of uncoupled, memoryless phases

Evidence that the human cell cycle is a series of uncoupled, memoryless phases

Abstract The cell cycle is canonically described as a series of four consecutive phases: G1, S, G2, and M. In single cells, the duration of each phase varies, but the quantitative laws that govern phase durations are not well understood. Using time‐lapse microscopy, we found that each phase duration...

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Bibliographic Details
Main Authors: Hui Xiao Chao, Randy I Fakhreddin, Hristo K Shimerov, Katarzyna M Kedziora, Rashmi J Kumar, Joanna Perez, Juanita C Limas, Gavin D Grant, Jeanette Gowen Cook, Gaorav P Gupta, Jeremy E Purvis
Format: Article
Language:English
Published: Springer Nature 2019-03-01
Series:Molecular Systems Biology
Subjects:
cell cycle
cell‐to‐cell variability
computational systems biology
Erlang model
single‐cell dynamics
Online Access:https://doi.org/10.15252/msb.20188604
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