The functional roles of deoxyelephantopin potential target circTNPO3 in regulating pancreatic cancer malignant phenotype and gemcitabine chemoresistance via miR-188-5p/CDCA3/TRAF2-mediated remodeling of NF-κB signaling pathway

The functional roles of deoxyelephantopin potential target circTNPO3 in regulating pancreatic cancer malignant phenotype and gemcitabine chemoresistance via miR-188-5p/CDCA3/TRAF2-mediated remodeling of NF-κB signaling pathway

BackgroundPancreatic cancer (PC) has been one of the most severe digestive system malignant tumor with poor prognosis that threatens human health. Chemotherapy is essential for patients with advanced PC, but unfortunately the curative effect is limited by chemoresistance. CircTNPO3, a recently disco...

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Main Authors: Daolin Ji, Jia Liu, Yanhui Zhang, Li Hou, Haonan Feng, Xue Xing, Deming Guan, Tiangang Cui, Yi Xu, Gang Tan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
pancreatic cancer
circTNPO3
chemoresistance
stemness
deoxyelephantopin
gemcitabine
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1613560/full
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