Synthesis and In Vitro Antimicrobial, Anthelmintic and Insecticidal Activities Study of 4(4'-Bromophenyl)-6-substituted-aryl-1-acetyl pyrimidine-2-thiols
A new series of 4(4'-bromophenyl)-6-substituted aryl-1-acetyl pyrimidine-2-thiol derivatives were synthesized by heating chalcones with thiourea, in the presence of ethanolic potassium hydroxide, followed by treatment with acetyl chloride. The structure of the compounds was characterized by IR...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2010/927601 |
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| author | Rita Bamnela S. P. Shrivastava |
| author_facet | Rita Bamnela S. P. Shrivastava |
| author_sort | Rita Bamnela |
| collection | DOAJ |
| description | A new series of 4(4'-bromophenyl)-6-substituted aryl-1-acetyl pyrimidine-2-thiol derivatives were synthesized by heating chalcones with thiourea, in the presence of ethanolic potassium hydroxide, followed by treatment with acetyl chloride. The structure of the compounds was characterized by IR and H1 NMR spectral study and elemental analysis. The compounds were screened for their antimicrobial, anthelmintic and insecticidal activities. All the compounds exhibited significant to moderate biological activities. |
| format | Article |
| id | doaj-art-81202d0df5694cbea6a27effd44270cf |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-81202d0df5694cbea6a27effd44270cf2025-02-03T01:12:11ZengWileyE-Journal of Chemistry0973-49452090-98102010-01-017393594110.1155/2010/927601Synthesis and In Vitro Antimicrobial, Anthelmintic and Insecticidal Activities Study of 4(4'-Bromophenyl)-6-substituted-aryl-1-acetyl pyrimidine-2-thiolsRita Bamnela0S. P. Shrivastava1Department of Chemistry, Govt. P.G. College, Damoh, M.P.-470 661, IndiaSynthetic Organic Laboratory, Department of Chemistry, Dr. Hari Singh Gour, University, Sagar - 470 003, M.P, IndiaA new series of 4(4'-bromophenyl)-6-substituted aryl-1-acetyl pyrimidine-2-thiol derivatives were synthesized by heating chalcones with thiourea, in the presence of ethanolic potassium hydroxide, followed by treatment with acetyl chloride. The structure of the compounds was characterized by IR and H1 NMR spectral study and elemental analysis. The compounds were screened for their antimicrobial, anthelmintic and insecticidal activities. All the compounds exhibited significant to moderate biological activities.http://dx.doi.org/10.1155/2010/927601 |
| spellingShingle | Rita Bamnela S. P. Shrivastava Synthesis and In Vitro Antimicrobial, Anthelmintic and Insecticidal Activities Study of 4(4'-Bromophenyl)-6-substituted-aryl-1-acetyl pyrimidine-2-thiols E-Journal of Chemistry |
| title | Synthesis and In Vitro Antimicrobial, Anthelmintic and Insecticidal Activities Study of 4(4'-Bromophenyl)-6-substituted-aryl-1-acetyl pyrimidine-2-thiols |
| title_full | Synthesis and In Vitro Antimicrobial, Anthelmintic and Insecticidal Activities Study of 4(4'-Bromophenyl)-6-substituted-aryl-1-acetyl pyrimidine-2-thiols |
| title_fullStr | Synthesis and In Vitro Antimicrobial, Anthelmintic and Insecticidal Activities Study of 4(4'-Bromophenyl)-6-substituted-aryl-1-acetyl pyrimidine-2-thiols |
| title_full_unstemmed | Synthesis and In Vitro Antimicrobial, Anthelmintic and Insecticidal Activities Study of 4(4'-Bromophenyl)-6-substituted-aryl-1-acetyl pyrimidine-2-thiols |
| title_short | Synthesis and In Vitro Antimicrobial, Anthelmintic and Insecticidal Activities Study of 4(4'-Bromophenyl)-6-substituted-aryl-1-acetyl pyrimidine-2-thiols |
| title_sort | synthesis and in vitro antimicrobial anthelmintic and insecticidal activities study of 4 4 bromophenyl 6 substituted aryl 1 acetyl pyrimidine 2 thiols |
| url | http://dx.doi.org/10.1155/2010/927601 |
| work_keys_str_mv | AT ritabamnela synthesisandinvitroantimicrobialanthelminticandinsecticidalactivitiesstudyof44bromophenyl6substitutedaryl1acetylpyrimidine2thiols AT spshrivastava synthesisandinvitroantimicrobialanthelminticandinsecticidalactivitiesstudyof44bromophenyl6substitutedaryl1acetylpyrimidine2thiols |