Association between lipid accumulation products and relative handgrip strength: a large population-based study
Abstract Given the increasing prevalence of chronic diseases in the aging population, it is of great importance to gain an understanding of how changes in body composition affect health outcomes. Handgrip strength (HGS) serves as a valuable proxy for overall muscle strength, while relative HGS (RHGS...
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Nature Portfolio
2025-04-01
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| Online Access: | https://doi.org/10.1038/s41598-025-96481-x |
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| author | Qian Wu Yicheng Ling Guiqiang Yuan Rui La Bin Xu Erkai Pang Chuan Lin Zhanghuan Chen Zhigang Zhang Dinghua Jiang Lixin Huang Jiangnan Xu Yubo Mao |
| author_facet | Qian Wu Yicheng Ling Guiqiang Yuan Rui La Bin Xu Erkai Pang Chuan Lin Zhanghuan Chen Zhigang Zhang Dinghua Jiang Lixin Huang Jiangnan Xu Yubo Mao |
| author_sort | Qian Wu |
| collection | DOAJ |
| description | Abstract Given the increasing prevalence of chronic diseases in the aging population, it is of great importance to gain an understanding of how changes in body composition affect health outcomes. Handgrip strength (HGS) serves as a valuable proxy for overall muscle strength, while relative HGS (RHGS) adjusts for body size, providing a more accurate assessment of the relationship between muscle strength and metabolic disease. Lipid accumulation products (LAP) are an indicator that can reflect visceral lipid accumulation. Based on previous studies, the relationship between LAP and RHGS has not been explored. This study aims to address this gap in the literature and provide insights for public health recommendations. Data was collected and extracted from the 2011–2014 National Health and Nutrition Examination Survey (NHANES) database. LAP was calculated from the arithmetic product of waist circumference (WC) and fasting plasma triglyceride (TG), the calculation as following formulas: for females, [WC (cm) − 58] × [TG (mmol/l)], and for males, [WC (cm) − 65] × [TG (mmol/l)]; RHGS was derived from the HGS to BMI ratio. The correlation between the variables was initially explored using multivariate linear regression. Secondly, smoothed-fitted curves were used to investigate the non-linear relationship between the variables. The inflection point values were determined based on the results of the threshold effect analysis. Subgroup analyses were also conducted to assess the stability of the relationship between the variables in different populations. The study analyzed 3990 patients. After accounting for different covariates, multivariate linear regression analysis demonstrated a significant negative correlation between increased levels of LAP and increased levels of RHGS (beta coefficient = -0.0020; 95% confidence interval CI: -0.0023 to -0.0017; P < 0.0001). The interaction test did not have a statistically significant effect on this association. Furthermore, curve fit and threshold effect analysis demonstrated a non-linear relationship with a breakpoint at 49.8083 cm·mmol/L. The results of this study demonstrate an inverse relationship between LAP and RHGS in various populations in the United States. These findings provide compelling evidence of the clinical significance of LAP as a predictor of RHGS, offering valuable insights for developing early intervention strategies in high-risk populations. |
| format | Article |
| id | doaj-art-81134dfd37cf4bad9ee055a46c6d89ad |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-81134dfd37cf4bad9ee055a46c6d89ad2025-08-20T03:05:01ZengNature PortfolioScientific Reports2045-23222025-04-0115111210.1038/s41598-025-96481-xAssociation between lipid accumulation products and relative handgrip strength: a large population-based studyQian Wu0Yicheng Ling1Guiqiang Yuan2Rui La3Bin Xu4Erkai Pang5Chuan Lin6Zhanghuan Chen7Zhigang Zhang8Dinghua Jiang9Lixin Huang10Jiangnan Xu11Yubo Mao12Department of Orthopedic Surgery, Wuxi Ninth People’s Hospital Affiliated to Soochow UniversityDepartment of Orthopedic Surgery and Sports Medicine, Institute of Orthopedics, The First Affiliated Hospital of Soochow University, Soochow UniversityBeijing Neurosurgical Institute, Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Capital Medical UniversityDepartment of Orthopedic Surgery and Sports Medicine, Institute of Orthopedics, The First Affiliated Hospital of Soochow University, Soochow UniversityDepartment of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Sports Medicine, Honghui Hospital, Xi’an Jiaotong University Medical CollegeDepartment of Biomedical Sciences, Institute for Medical Science, Jeonbuk National University Medical SchoolDepartment of Pediatric Surgery, Kunshan First People’s HospitalDepartment of Orthopedic Surgery and Sports Medicine, Institute of Orthopedics, The First Affiliated Hospital of Soochow University, Soochow UniversityDepartment of Orthopedic Surgery and Sports Medicine, Institute of Orthopedics, The First Affiliated Hospital of Soochow University, Soochow UniversityDepartment of Orthopedic Surgery and Sports Medicine, Institute of Orthopedics, The First Affiliated Hospital of Soochow University, Soochow UniversityDepartment of Urology, Medical School, Yancheng First Hospital, Affiliated Hospital of Nanjing University, The First People’s Hospital of YanchengDepartment of Orthopedic Surgery, Wuxi Ninth People’s Hospital Affiliated to Soochow UniversityAbstract Given the increasing prevalence of chronic diseases in the aging population, it is of great importance to gain an understanding of how changes in body composition affect health outcomes. Handgrip strength (HGS) serves as a valuable proxy for overall muscle strength, while relative HGS (RHGS) adjusts for body size, providing a more accurate assessment of the relationship between muscle strength and metabolic disease. Lipid accumulation products (LAP) are an indicator that can reflect visceral lipid accumulation. Based on previous studies, the relationship between LAP and RHGS has not been explored. This study aims to address this gap in the literature and provide insights for public health recommendations. Data was collected and extracted from the 2011–2014 National Health and Nutrition Examination Survey (NHANES) database. LAP was calculated from the arithmetic product of waist circumference (WC) and fasting plasma triglyceride (TG), the calculation as following formulas: for females, [WC (cm) − 58] × [TG (mmol/l)], and for males, [WC (cm) − 65] × [TG (mmol/l)]; RHGS was derived from the HGS to BMI ratio. The correlation between the variables was initially explored using multivariate linear regression. Secondly, smoothed-fitted curves were used to investigate the non-linear relationship between the variables. The inflection point values were determined based on the results of the threshold effect analysis. Subgroup analyses were also conducted to assess the stability of the relationship between the variables in different populations. The study analyzed 3990 patients. After accounting for different covariates, multivariate linear regression analysis demonstrated a significant negative correlation between increased levels of LAP and increased levels of RHGS (beta coefficient = -0.0020; 95% confidence interval CI: -0.0023 to -0.0017; P < 0.0001). The interaction test did not have a statistically significant effect on this association. Furthermore, curve fit and threshold effect analysis demonstrated a non-linear relationship with a breakpoint at 49.8083 cm·mmol/L. The results of this study demonstrate an inverse relationship between LAP and RHGS in various populations in the United States. These findings provide compelling evidence of the clinical significance of LAP as a predictor of RHGS, offering valuable insights for developing early intervention strategies in high-risk populations.https://doi.org/10.1038/s41598-025-96481-xRelative handgrip strengthLipid accumulation productsNational health and nutrition examination survey |
| spellingShingle | Qian Wu Yicheng Ling Guiqiang Yuan Rui La Bin Xu Erkai Pang Chuan Lin Zhanghuan Chen Zhigang Zhang Dinghua Jiang Lixin Huang Jiangnan Xu Yubo Mao Association between lipid accumulation products and relative handgrip strength: a large population-based study Scientific Reports Relative handgrip strength Lipid accumulation products National health and nutrition examination survey |
| title | Association between lipid accumulation products and relative handgrip strength: a large population-based study |
| title_full | Association between lipid accumulation products and relative handgrip strength: a large population-based study |
| title_fullStr | Association between lipid accumulation products and relative handgrip strength: a large population-based study |
| title_full_unstemmed | Association between lipid accumulation products and relative handgrip strength: a large population-based study |
| title_short | Association between lipid accumulation products and relative handgrip strength: a large population-based study |
| title_sort | association between lipid accumulation products and relative handgrip strength a large population based study |
| topic | Relative handgrip strength Lipid accumulation products National health and nutrition examination survey |
| url | https://doi.org/10.1038/s41598-025-96481-x |
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