Complex congenital heart and lung defects as a cause of hydrops fetalis in French bulldogs –micro-CT with contrast study
Abstract Limited data are available on the causes of hydrops fetalis in dogs. Congenital heart defects may be an important contributing factor. Standard autopsy often fails to provide a comprehensive and accurate diagnosis on very small hearts. This study was carried out on five French bulldog puppi...
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Nature Portfolio
2025-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-88495-2 |
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| author | Olga Szaluś-Jordanow Karolina Barszcz Wojciech Mądry Michał Buczyński Michał Czopowicz Adam Gierulski Agata Moroz-Fik Zofia Nowek Marcin Mickiewicz Michał Grzegorczyk Jakub Jaroszewicz Sylwia Tarka Tomasz Stępień Wojciech Święszkowski |
| author_facet | Olga Szaluś-Jordanow Karolina Barszcz Wojciech Mądry Michał Buczyński Michał Czopowicz Adam Gierulski Agata Moroz-Fik Zofia Nowek Marcin Mickiewicz Michał Grzegorczyk Jakub Jaroszewicz Sylwia Tarka Tomasz Stępień Wojciech Święszkowski |
| author_sort | Olga Szaluś-Jordanow |
| collection | DOAJ |
| description | Abstract Limited data are available on the causes of hydrops fetalis in dogs. Congenital heart defects may be an important contributing factor. Standard autopsy often fails to provide a comprehensive and accurate diagnosis on very small hearts. This study was carried out on five French bulldog puppies all presenting with advanced hydrops fetalis and four diagnosed with pulmonary hypoplasia at autopsy. The body weight of the dogs ranged from 142 to 687 g and the heart with lungs weighed from 4.5 to 23.6 g. The hearts and pulmonary vessels were filled with barium contrast, and micro-CT scans of the physiologically connected heart and lungs were performed. In all five puppies, we confirmed congenital heart defects including: Puppy #1. Perimembranous ventricular septal defect and aortic dextroposition; Puppy #2. Interrupted aortic arch with aortic valve dysplasia and aortic stenosis; Puppy #3. Tricuspid valve dysplasia and bicuspid pulmonary trunk valve; Puppy #4. Aortic stenosis and ventricular septal defect; Puppy #5. Tricuspid valve dysplasia. Additionally, four puppies had pulmonary vascular hypoplasia. Contrast-enhanced micro-CT can provide highly accurate diagnosis of complex congenital heart and lung defects. Examination of the heart in conjunction with the lungs appears to be a rational approach in animals with hydrops fetalis. |
| format | Article |
| id | doaj-art-8110e862646c4bfbacd5afddcc61f4c3 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-8110e862646c4bfbacd5afddcc61f4c32025-02-09T12:28:51ZengNature PortfolioScientific Reports2045-23222025-02-0115111210.1038/s41598-025-88495-2Complex congenital heart and lung defects as a cause of hydrops fetalis in French bulldogs –micro-CT with contrast studyOlga Szaluś-Jordanow0Karolina Barszcz1Wojciech Mądry2Michał Buczyński3Michał Czopowicz4Adam Gierulski5Agata Moroz-Fik6Zofia Nowek7Marcin Mickiewicz8Michał Grzegorczyk9Jakub Jaroszewicz10Sylwia Tarka11Tomasz Stępień12Wojciech Święszkowski13Department of Small Animal Diseases with Clinic, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGWDepartment of Morphological Sciences Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGWDepartment of Heart, Chest and Transplant Surgery, Medical University of WarsawDepartment of Heart, Chest and Transplant Surgery, Medical University of WarsawDivision of Veterinary Epidemiology and Economics, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGWAniCura Animal Veterinary ClinicDivision of Veterinary Epidemiology and Economics, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGWDivision of Veterinary Epidemiology and Economics, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGWDivision of Veterinary Epidemiology and Economics, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGWDepartment of Descriptive and Clinical Anatomy, Medical University of WarsawFaculty of Materials Science and Engineering, Warsaw University of TechnologyDepartment of Forensic Medicine, Medical University of WarsawDepartment of Neuropathology, Institute of Psychiatry and NeurologyFaculty of Materials Science and Engineering, Warsaw University of TechnologyAbstract Limited data are available on the causes of hydrops fetalis in dogs. Congenital heart defects may be an important contributing factor. Standard autopsy often fails to provide a comprehensive and accurate diagnosis on very small hearts. This study was carried out on five French bulldog puppies all presenting with advanced hydrops fetalis and four diagnosed with pulmonary hypoplasia at autopsy. The body weight of the dogs ranged from 142 to 687 g and the heart with lungs weighed from 4.5 to 23.6 g. The hearts and pulmonary vessels were filled with barium contrast, and micro-CT scans of the physiologically connected heart and lungs were performed. In all five puppies, we confirmed congenital heart defects including: Puppy #1. Perimembranous ventricular septal defect and aortic dextroposition; Puppy #2. Interrupted aortic arch with aortic valve dysplasia and aortic stenosis; Puppy #3. Tricuspid valve dysplasia and bicuspid pulmonary trunk valve; Puppy #4. Aortic stenosis and ventricular septal defect; Puppy #5. Tricuspid valve dysplasia. Additionally, four puppies had pulmonary vascular hypoplasia. Contrast-enhanced micro-CT can provide highly accurate diagnosis of complex congenital heart and lung defects. Examination of the heart in conjunction with the lungs appears to be a rational approach in animals with hydrops fetalis.https://doi.org/10.1038/s41598-025-88495-2 |
| spellingShingle | Olga Szaluś-Jordanow Karolina Barszcz Wojciech Mądry Michał Buczyński Michał Czopowicz Adam Gierulski Agata Moroz-Fik Zofia Nowek Marcin Mickiewicz Michał Grzegorczyk Jakub Jaroszewicz Sylwia Tarka Tomasz Stępień Wojciech Święszkowski Complex congenital heart and lung defects as a cause of hydrops fetalis in French bulldogs –micro-CT with contrast study Scientific Reports |
| title | Complex congenital heart and lung defects as a cause of hydrops fetalis in French bulldogs –micro-CT with contrast study |
| title_full | Complex congenital heart and lung defects as a cause of hydrops fetalis in French bulldogs –micro-CT with contrast study |
| title_fullStr | Complex congenital heart and lung defects as a cause of hydrops fetalis in French bulldogs –micro-CT with contrast study |
| title_full_unstemmed | Complex congenital heart and lung defects as a cause of hydrops fetalis in French bulldogs –micro-CT with contrast study |
| title_short | Complex congenital heart and lung defects as a cause of hydrops fetalis in French bulldogs –micro-CT with contrast study |
| title_sort | complex congenital heart and lung defects as a cause of hydrops fetalis in french bulldogs micro ct with contrast study |
| url | https://doi.org/10.1038/s41598-025-88495-2 |
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