Nanotechnology in Osteogenesis and Inflammation Management: Metal–Organic Frameworks, Metal Complexes, and Biomaterials for Bone Restoration
A varied family of polyphenolic chemicals, flavonoids, are becoming more and more important in bone tissue engineering because of their osteogenic, anti-inflammatory, and antioxidant effects. Recent developments incorporating flavonoids into different biomaterial platforms to improve bone regenerati...
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2025-06-01
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| author | Bogdan Huzum Ionut Iulian Lungu Ovidiu Alexa Paul Dan Sirbu Viorel Dan Cionca Andreia Corciova Andreea Lungu Monica Hancianu Ionela Lacramioara Serban Oana Cioanca |
| author_facet | Bogdan Huzum Ionut Iulian Lungu Ovidiu Alexa Paul Dan Sirbu Viorel Dan Cionca Andreia Corciova Andreea Lungu Monica Hancianu Ionela Lacramioara Serban Oana Cioanca |
| author_sort | Bogdan Huzum |
| collection | DOAJ |
| description | A varied family of polyphenolic chemicals, flavonoids, are becoming more and more important in bone tissue engineering because of their osteogenic, anti-inflammatory, and antioxidant effects. Recent developments incorporating flavonoids into different biomaterial platforms to improve bone regeneration are emphasized in this study. Osteocalcin (OCN) expression was 2.1-fold greater in scaffolds loaded with flavonoids—such as those made of polycaprolactone (PCL)—greatly increasing human mesenchymal stem cell (hMSC) proliferation and mineralization. Comparably, a threefold increase in calcium deposition indicates increased mineralization when hydroxyapatite (HA) was functionalized with flavonoids such as quercetin. These HA scaffolds with flavonoids also showed a 45% decrease in osteoclast activity, therefore promoting balanced bone remodeling. Concurrent with flavonoids like EGCG and quercetin, chitosan-based scaffolds encouraged osteogenic differentiation with increases in osteogenic markers like osteopontin (OPN) and alkaline phosphatase (ALP) expression by up to 82%. These scaffolds also showed 82% bone defect repair after six weeks in vivo, suggesting their promise in rapid bone regeneration. With an increase of up to 32% in the bone volume-to-total volume ratio (BV/TV) and 28% greater bone–implant contact (BIC), flavonoid coatings on titanium implants enhanced osteointegration in implantology. Displaying successful osteogenesis and immunomodulation, the addition of flavonoids into metal–organic frameworks (MOFs) and injectable hydrogels demonstrated a 72% increase in new bone formation in vivo. Though further research is required to confirm long-term clinical effectiveness, these findings show the great promise of flavonoid-functionalized biomaterials in bone regeneration. |
| format | Article |
| id | doaj-art-810ffc87fd1a4e26a08c32050fc59d24 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-810ffc87fd1a4e26a08c32050fc59d242025-08-20T03:36:31ZengMDPI AGBiomedicines2227-90592025-06-01137159710.3390/biomedicines13071597Nanotechnology in Osteogenesis and Inflammation Management: Metal–Organic Frameworks, Metal Complexes, and Biomaterials for Bone RestorationBogdan Huzum0Ionut Iulian Lungu1Ovidiu Alexa2Paul Dan Sirbu3Viorel Dan Cionca4Andreia Corciova5Andreea Lungu6Monica Hancianu7Ionela Lacramioara Serban8Oana Cioanca9Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Independentei Street, No. 16, 700115 Iasi, RomaniaFaculty of Pharmacy, “Grigore T. Popa”, University of Medicine and Pharmacy Independentei Street, No. 16, 700115 Iasi, RomaniaFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Independentei Street, No. 16, 700115 Iasi, RomaniaFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Independentei Street, No. 16, 700115 Iasi, Romania“St. Spiridon” County Clinical Emergency Hospital, Independentei Bd., No. 1, 700111 Iasi, RomaniaFaculty of Pharmacy, “Grigore T. Popa”, University of Medicine and Pharmacy Independentei Street, No. 16, 700115 Iasi, RomaniaFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Independentei Street, No. 16, 700115 Iasi, RomaniaFaculty of Pharmacy, “Grigore T. Popa”, University of Medicine and Pharmacy Independentei Street, No. 16, 700115 Iasi, RomaniaFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Independentei Street, No. 16, 700115 Iasi, RomaniaFaculty of Pharmacy, “Grigore T. Popa”, University of Medicine and Pharmacy Independentei Street, No. 16, 700115 Iasi, RomaniaA varied family of polyphenolic chemicals, flavonoids, are becoming more and more important in bone tissue engineering because of their osteogenic, anti-inflammatory, and antioxidant effects. Recent developments incorporating flavonoids into different biomaterial platforms to improve bone regeneration are emphasized in this study. Osteocalcin (OCN) expression was 2.1-fold greater in scaffolds loaded with flavonoids—such as those made of polycaprolactone (PCL)—greatly increasing human mesenchymal stem cell (hMSC) proliferation and mineralization. Comparably, a threefold increase in calcium deposition indicates increased mineralization when hydroxyapatite (HA) was functionalized with flavonoids such as quercetin. These HA scaffolds with flavonoids also showed a 45% decrease in osteoclast activity, therefore promoting balanced bone remodeling. Concurrent with flavonoids like EGCG and quercetin, chitosan-based scaffolds encouraged osteogenic differentiation with increases in osteogenic markers like osteopontin (OPN) and alkaline phosphatase (ALP) expression by up to 82%. These scaffolds also showed 82% bone defect repair after six weeks in vivo, suggesting their promise in rapid bone regeneration. With an increase of up to 32% in the bone volume-to-total volume ratio (BV/TV) and 28% greater bone–implant contact (BIC), flavonoid coatings on titanium implants enhanced osteointegration in implantology. Displaying successful osteogenesis and immunomodulation, the addition of flavonoids into metal–organic frameworks (MOFs) and injectable hydrogels demonstrated a 72% increase in new bone formation in vivo. Though further research is required to confirm long-term clinical effectiveness, these findings show the great promise of flavonoid-functionalized biomaterials in bone regeneration.https://www.mdpi.com/2227-9059/13/7/1597osteoporosisosteogenesisflavonoidsnanotechnologyimplants |
| spellingShingle | Bogdan Huzum Ionut Iulian Lungu Ovidiu Alexa Paul Dan Sirbu Viorel Dan Cionca Andreia Corciova Andreea Lungu Monica Hancianu Ionela Lacramioara Serban Oana Cioanca Nanotechnology in Osteogenesis and Inflammation Management: Metal–Organic Frameworks, Metal Complexes, and Biomaterials for Bone Restoration Biomedicines osteoporosis osteogenesis flavonoids nanotechnology implants |
| title | Nanotechnology in Osteogenesis and Inflammation Management: Metal–Organic Frameworks, Metal Complexes, and Biomaterials for Bone Restoration |
| title_full | Nanotechnology in Osteogenesis and Inflammation Management: Metal–Organic Frameworks, Metal Complexes, and Biomaterials for Bone Restoration |
| title_fullStr | Nanotechnology in Osteogenesis and Inflammation Management: Metal–Organic Frameworks, Metal Complexes, and Biomaterials for Bone Restoration |
| title_full_unstemmed | Nanotechnology in Osteogenesis and Inflammation Management: Metal–Organic Frameworks, Metal Complexes, and Biomaterials for Bone Restoration |
| title_short | Nanotechnology in Osteogenesis and Inflammation Management: Metal–Organic Frameworks, Metal Complexes, and Biomaterials for Bone Restoration |
| title_sort | nanotechnology in osteogenesis and inflammation management metal organic frameworks metal complexes and biomaterials for bone restoration |
| topic | osteoporosis osteogenesis flavonoids nanotechnology implants |
| url | https://www.mdpi.com/2227-9059/13/7/1597 |
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