Association between vitamin D levels and preserved ratio impaired spirometry: an investigation of mediating roles of systemic inflammation and metabolic indicators
BackgroundPreserved ratio impaired spirometry (PRISm) represents an abnormal lung function state distinct from traditional chronic obstructive pulmonary disease, characterized by unique clinical and epidemiological features. PRISm has been associated with various health issues, including an increase...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1527333/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832582956824133632 |
|---|---|
| author | Tong Lin Shanshan Huang Fen Zhou Xingkai Shen Haiyan Mao |
| author_facet | Tong Lin Shanshan Huang Fen Zhou Xingkai Shen Haiyan Mao |
| author_sort | Tong Lin |
| collection | DOAJ |
| description | BackgroundPreserved ratio impaired spirometry (PRISm) represents an abnormal lung function state distinct from traditional chronic obstructive pulmonary disease, characterized by unique clinical and epidemiological features. PRISm has been associated with various health issues, including an increased risk of metabolic disorders and cardiovascular diseases. Vitamin D, known for its anti-inflammatory, immunomodulatory, and antioxidant properties, may play a role in reducing the risk of PRISm. This study aims to investigate the relationship between vitamin D levels and PRISm, including the mediating effects of systemic inflammation markers and metabolic indicators in a population of U.S. adults.MethodsThis cross-sectional study analyzed data from 17,333 participants from the U.S. National Health and Nutrition Examination Survey, including 1,577 individuals with PRISm and 15,756 without. Baseline characteristics were assessed, and multivariate logistic regression models were employed to examine the relationship between vitamin D and PRISm. Mediation analysis was conducted to explore potential mediating roles of systemic immune-inflammation index (SII), triglyceride-glucose (TyG) index, and bilirubin. Nonlinear relationships were assessed using restricted cubic spline (RCS) models.ResultsThe PRISm group had lower median vitamin D levels and distinct inflammatory and metabolic profiles compared to the non-PRISm group. Multivariate analysis confirmed an inverse association between vitamin D levels and PRISm (adjusted OR: 0.989, 95% CI: 0.984–0.994, p < 0.001). RCS analysis showed a nonlinear protective effect of vitamin D, with risk stabilizing at levels above 50 nmol/mL. Mediation analysis highlighted bilirubin as a positive mediator (ACME = −4.11 × 10−5, p < 0.001), while TyG demonstrated a suppressive mediation effect (ACME = 2.68 × 10−5, p < 0.001). SII did not show significant mediation.ConclusionElevated vitamin D levels are linked to a lower risk of PRISm, with bilirubin potentially acting as a mediator in this protective relationship. This underscores the clinical significance of maintaining sufficient vitamin D levels to promote lung health and mitigate the prevalence of PRISm among U.S. adults. Further research is warranted to investigate personalized vitamin D supplementation strategies as a potential preventive approach. |
| format | Article |
| id | doaj-art-810f72740b2a49b8b71fd835f92ecdda |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-810f72740b2a49b8b71fd835f92ecdda2025-01-29T05:21:10ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011210.3389/fnut.2025.15273331527333Association between vitamin D levels and preserved ratio impaired spirometry: an investigation of mediating roles of systemic inflammation and metabolic indicatorsTong Lin0Shanshan Huang1Fen Zhou2Xingkai Shen3Haiyan Mao4Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo, ChinaDepartment of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo, ChinaDepartment of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo, ChinaDepartment of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo, ChinaDepartment of Geriatrics, Ningbo Medical Center Lihuili Hospital, Ningbo, ChinaBackgroundPreserved ratio impaired spirometry (PRISm) represents an abnormal lung function state distinct from traditional chronic obstructive pulmonary disease, characterized by unique clinical and epidemiological features. PRISm has been associated with various health issues, including an increased risk of metabolic disorders and cardiovascular diseases. Vitamin D, known for its anti-inflammatory, immunomodulatory, and antioxidant properties, may play a role in reducing the risk of PRISm. This study aims to investigate the relationship between vitamin D levels and PRISm, including the mediating effects of systemic inflammation markers and metabolic indicators in a population of U.S. adults.MethodsThis cross-sectional study analyzed data from 17,333 participants from the U.S. National Health and Nutrition Examination Survey, including 1,577 individuals with PRISm and 15,756 without. Baseline characteristics were assessed, and multivariate logistic regression models were employed to examine the relationship between vitamin D and PRISm. Mediation analysis was conducted to explore potential mediating roles of systemic immune-inflammation index (SII), triglyceride-glucose (TyG) index, and bilirubin. Nonlinear relationships were assessed using restricted cubic spline (RCS) models.ResultsThe PRISm group had lower median vitamin D levels and distinct inflammatory and metabolic profiles compared to the non-PRISm group. Multivariate analysis confirmed an inverse association between vitamin D levels and PRISm (adjusted OR: 0.989, 95% CI: 0.984–0.994, p < 0.001). RCS analysis showed a nonlinear protective effect of vitamin D, with risk stabilizing at levels above 50 nmol/mL. Mediation analysis highlighted bilirubin as a positive mediator (ACME = −4.11 × 10−5, p < 0.001), while TyG demonstrated a suppressive mediation effect (ACME = 2.68 × 10−5, p < 0.001). SII did not show significant mediation.ConclusionElevated vitamin D levels are linked to a lower risk of PRISm, with bilirubin potentially acting as a mediator in this protective relationship. This underscores the clinical significance of maintaining sufficient vitamin D levels to promote lung health and mitigate the prevalence of PRISm among U.S. adults. Further research is warranted to investigate personalized vitamin D supplementation strategies as a potential preventive approach.https://www.frontiersin.org/articles/10.3389/fnut.2025.1527333/fullvitamin Dpreserved ratio impaired spirometryrespiratory diseasemediation analysisNHANES |
| spellingShingle | Tong Lin Shanshan Huang Fen Zhou Xingkai Shen Haiyan Mao Association between vitamin D levels and preserved ratio impaired spirometry: an investigation of mediating roles of systemic inflammation and metabolic indicators Frontiers in Nutrition vitamin D preserved ratio impaired spirometry respiratory disease mediation analysis NHANES |
| title | Association between vitamin D levels and preserved ratio impaired spirometry: an investigation of mediating roles of systemic inflammation and metabolic indicators |
| title_full | Association between vitamin D levels and preserved ratio impaired spirometry: an investigation of mediating roles of systemic inflammation and metabolic indicators |
| title_fullStr | Association between vitamin D levels and preserved ratio impaired spirometry: an investigation of mediating roles of systemic inflammation and metabolic indicators |
| title_full_unstemmed | Association between vitamin D levels and preserved ratio impaired spirometry: an investigation of mediating roles of systemic inflammation and metabolic indicators |
| title_short | Association between vitamin D levels and preserved ratio impaired spirometry: an investigation of mediating roles of systemic inflammation and metabolic indicators |
| title_sort | association between vitamin d levels and preserved ratio impaired spirometry an investigation of mediating roles of systemic inflammation and metabolic indicators |
| topic | vitamin D preserved ratio impaired spirometry respiratory disease mediation analysis NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1527333/full |
| work_keys_str_mv | AT tonglin associationbetweenvitamindlevelsandpreservedratioimpairedspirometryaninvestigationofmediatingrolesofsystemicinflammationandmetabolicindicators AT shanshanhuang associationbetweenvitamindlevelsandpreservedratioimpairedspirometryaninvestigationofmediatingrolesofsystemicinflammationandmetabolicindicators AT fenzhou associationbetweenvitamindlevelsandpreservedratioimpairedspirometryaninvestigationofmediatingrolesofsystemicinflammationandmetabolicindicators AT xingkaishen associationbetweenvitamindlevelsandpreservedratioimpairedspirometryaninvestigationofmediatingrolesofsystemicinflammationandmetabolicindicators AT haiyanmao associationbetweenvitamindlevelsandpreservedratioimpairedspirometryaninvestigationofmediatingrolesofsystemicinflammationandmetabolicindicators |