Effect of Hepatitis C Infection on Semen Parameters of Men From Rawalpindi and Islamabad, Punjab, Pakistan
Hepatitis C virus (HCV) poses a global health challenge, especially due to its genetic diversity and capacity to infect 71 million people worldwide. This infection is prevalent in Pakistan, with 15% of the population affected, with varying rates across provinces. HCV primarily targets liver cells bu...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-02-01
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| Series: | American Journal of Men's Health |
| Online Access: | https://doi.org/10.1177/15579883251316564 |
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| author | Jamal Uddin Shamim Akhter Muhammad Javaid Asad Muhammad Irfan Mazhar Qayyum Majid Aijaz Shahzad Aslam |
| author_facet | Jamal Uddin Shamim Akhter Muhammad Javaid Asad Muhammad Irfan Mazhar Qayyum Majid Aijaz Shahzad Aslam |
| author_sort | Jamal Uddin |
| collection | DOAJ |
| description | Hepatitis C virus (HCV) poses a global health challenge, especially due to its genetic diversity and capacity to infect 71 million people worldwide. This infection is prevalent in Pakistan, with 15% of the population affected, with varying rates across provinces. HCV primarily targets liver cells but can also impact other bodily systems, including the reproductive system. Liver infection, oxidative stress, and inflammation may directly or indirectly affect the production, transport, and functions of reproductive hormones and sperm. This study hypothesized that HCV infection may reduce male fertility in the patients. In this case–control study, 74 HCV-infected men and 12 healthy controls from Rawalpindi and Islamabad were compared for semen quality. Participants provided semen samples following strict guidelines, ensuring the reliability of results. The semen analysis, conducted using manual and computer-assisted techniques, revealed significant ( p < .05) reductions in volume, concentration, motility, and morphology among HCV-infected men compared to the control group. In addition, a weak negative correlation between virus load and semen parameters was observed. These findings reveal broader health implications of HCV beyond liver damage, highlighting the need for targeted reproductive health interventions for affected men. Improved fertility preservation options and informed reproductive guidance for HCV-infected men could significantly benefit those undergoing treatment. |
| format | Article |
| id | doaj-art-80fe3d00a8b74346828a26a45541be16 |
| institution | OA Journals |
| issn | 1557-9891 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | American Journal of Men's Health |
| spelling | doaj-art-80fe3d00a8b74346828a26a45541be162025-08-20T02:14:41ZengSAGE PublishingAmerican Journal of Men's Health1557-98912025-02-011910.1177/15579883251316564Effect of Hepatitis C Infection on Semen Parameters of Men From Rawalpindi and Islamabad, Punjab, PakistanJamal Uddin0Shamim Akhter1Muhammad Javaid Asad2Muhammad Irfan3Mazhar Qayyum4Majid Aijaz5Shahzad Aslam6Department of Zoology, Wildlife and Fisheries, Pir Mehr Ali Shah Arid Agriculture University Rawalpindi, Rawalpindi, PakistanDepartment of Zoology, Wildlife and Fisheries, Pir Mehr Ali Shah Arid Agriculture University Rawalpindi, Rawalpindi, PakistanUniversity Institute of Biochemistry and Biotechnology, Pir Mehr Ali Shah Arid Agriculture University Rawalpindi, Rawalpindi, PakistanDepartment of Zoology, Wildlife and Fisheries, Pir Mehr Ali Shah Arid Agriculture University Rawalpindi, Rawalpindi, PakistanDepartment of Zoology, Wildlife and Fisheries, Pir Mehr Ali Shah Arid Agriculture University Rawalpindi, Rawalpindi, PakistanDepartment of Zoology, Wildlife and Fisheries, Pir Mehr Ali Shah Arid Agriculture University Rawalpindi, Rawalpindi, PakistanDepartment of Zoology, Islamabad College for Boys G-6/3, Islamabad, PakistanHepatitis C virus (HCV) poses a global health challenge, especially due to its genetic diversity and capacity to infect 71 million people worldwide. This infection is prevalent in Pakistan, with 15% of the population affected, with varying rates across provinces. HCV primarily targets liver cells but can also impact other bodily systems, including the reproductive system. Liver infection, oxidative stress, and inflammation may directly or indirectly affect the production, transport, and functions of reproductive hormones and sperm. This study hypothesized that HCV infection may reduce male fertility in the patients. In this case–control study, 74 HCV-infected men and 12 healthy controls from Rawalpindi and Islamabad were compared for semen quality. Participants provided semen samples following strict guidelines, ensuring the reliability of results. The semen analysis, conducted using manual and computer-assisted techniques, revealed significant ( p < .05) reductions in volume, concentration, motility, and morphology among HCV-infected men compared to the control group. In addition, a weak negative correlation between virus load and semen parameters was observed. These findings reveal broader health implications of HCV beyond liver damage, highlighting the need for targeted reproductive health interventions for affected men. Improved fertility preservation options and informed reproductive guidance for HCV-infected men could significantly benefit those undergoing treatment.https://doi.org/10.1177/15579883251316564 |
| spellingShingle | Jamal Uddin Shamim Akhter Muhammad Javaid Asad Muhammad Irfan Mazhar Qayyum Majid Aijaz Shahzad Aslam Effect of Hepatitis C Infection on Semen Parameters of Men From Rawalpindi and Islamabad, Punjab, Pakistan American Journal of Men's Health |
| title | Effect of Hepatitis C Infection on Semen Parameters of Men From Rawalpindi and Islamabad, Punjab, Pakistan |
| title_full | Effect of Hepatitis C Infection on Semen Parameters of Men From Rawalpindi and Islamabad, Punjab, Pakistan |
| title_fullStr | Effect of Hepatitis C Infection on Semen Parameters of Men From Rawalpindi and Islamabad, Punjab, Pakistan |
| title_full_unstemmed | Effect of Hepatitis C Infection on Semen Parameters of Men From Rawalpindi and Islamabad, Punjab, Pakistan |
| title_short | Effect of Hepatitis C Infection on Semen Parameters of Men From Rawalpindi and Islamabad, Punjab, Pakistan |
| title_sort | effect of hepatitis c infection on semen parameters of men from rawalpindi and islamabad punjab pakistan |
| url | https://doi.org/10.1177/15579883251316564 |
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