Phenotypes of persistent hen`s egg allergy in children and adolescents
Background. Optimum management of food allergy (FA) includes consideration of co-allergies and multimorbidities and tolerance assessment. Documentation of FA practices may pave the way for better practice. Methods. Patients aged 3-18 years, with persistent IgE-mediated hen`s egg allerg...
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Hacettepe University Institute of Child Health
2023-02-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/2 |
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| author | Hilal Ünsal Sevda Tüten Dal Ayşegül Akarsu Ümit Murat Şahiner Özge Soyer Bülent Enis Şekerel |
| author_facet | Hilal Ünsal Sevda Tüten Dal Ayşegül Akarsu Ümit Murat Şahiner Özge Soyer Bülent Enis Şekerel |
| author_sort | Hilal Ünsal |
| collection | DOAJ |
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Background. Optimum management of food allergy (FA) includes consideration of co-allergies and multimorbidities and tolerance assessment. Documentation of FA practices may pave the way for better practice.
Methods. Patients aged 3-18 years, with persistent IgE-mediated hen`s egg allergy were reviewed.
Results. A total of 102 children with a median age of 59 months (IQR= 40-84) (72.2% males) were included. All were diagnosed during infancy and the initial symptoms were atopic dermatitis (65.6%), urticaria (18.6%), and anaphylaxis (5.9%). Of the total population, 21 (20.6%) experienced anaphylaxis with hen`s eggs, and 79.4%, 89.2%, and 30.4% had multiple FAs (≥2 food categories), ever atopic dermatitis, and asthma, respectively. The most common co-allergies were tree nuts, cow`s milk, and seeds, respectively. From 52 heated egg yolk and 47 baked egg oral food challenges, 48 (92.3%) and 41 (87.2%) were found as tolerant, respectively. The baked egg nontolerant group had a greater egg white skin prick test diameter [9 mm (IQR: 6-11.5) vs. 6 mm (IQR: 4.5-9); (p=0.009)] and specific IgE [12.6 kU/L (IQR: 4.11-45.4) vs. 6.2 kU/L (IQR: 1.9-12.4) (p=0.009)], respectively. In the multivariate analysis, baked egg tolerance was more likely in those with egg yolk-tolerant subgroup (OR: 6.480, 95% CI: 2.524-16.638; p < 0.001) and heated egg tolerance in those with baked egg tolerance (OR: 6.943, 95% CI: 1.554-31.017; p=0.011).
Conclusions. Persistent hen`s egg allergy is characterized by multiple food allergies and age-related multimorbidities. Baked egg and heated egg yolk tolerance were more likely to be considered in a subgroup with a high expectation for finding a way to eliminate their allergy.
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| format | Article |
| id | doaj-art-80fd7530e73543128237c60743bef615 |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-80fd7530e73543128237c60743bef6152025-08-20T02:17:50ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212023-02-0165110.24953/turkjped.2021.5417Phenotypes of persistent hen`s egg allergy in children and adolescentsHilal Ünsal0Sevda Tüten Dal1Ayşegül Akarsu2Ümit Murat Şahiner3Özge Soyer4Bülent Enis Şekerel5Division of Pediatric Allergy, Hacettepe University Faculty of Medicine, Ankara, Türkiye.Division of Pediatric Allergy, Hacettepe University Faculty of Medicine, Ankara, Türkiye.Division of Pediatric Allergy, Hacettepe University Faculty of Medicine, Ankara, Türkiye.Division of Pediatric Allergy, Hacettepe University Faculty of Medicine, Ankara, Türkiye.Division of Pediatric Allergy, Hacettepe University Faculty of Medicine, Ankara, Türkiye.Division of Pediatric Allergy, Hacettepe University Faculty of Medicine, Ankara, Türkiye. Background. Optimum management of food allergy (FA) includes consideration of co-allergies and multimorbidities and tolerance assessment. Documentation of FA practices may pave the way for better practice. Methods. Patients aged 3-18 years, with persistent IgE-mediated hen`s egg allergy were reviewed. Results. A total of 102 children with a median age of 59 months (IQR= 40-84) (72.2% males) were included. All were diagnosed during infancy and the initial symptoms were atopic dermatitis (65.6%), urticaria (18.6%), and anaphylaxis (5.9%). Of the total population, 21 (20.6%) experienced anaphylaxis with hen`s eggs, and 79.4%, 89.2%, and 30.4% had multiple FAs (≥2 food categories), ever atopic dermatitis, and asthma, respectively. The most common co-allergies were tree nuts, cow`s milk, and seeds, respectively. From 52 heated egg yolk and 47 baked egg oral food challenges, 48 (92.3%) and 41 (87.2%) were found as tolerant, respectively. The baked egg nontolerant group had a greater egg white skin prick test diameter [9 mm (IQR: 6-11.5) vs. 6 mm (IQR: 4.5-9); (p=0.009)] and specific IgE [12.6 kU/L (IQR: 4.11-45.4) vs. 6.2 kU/L (IQR: 1.9-12.4) (p=0.009)], respectively. In the multivariate analysis, baked egg tolerance was more likely in those with egg yolk-tolerant subgroup (OR: 6.480, 95% CI: 2.524-16.638; p < 0.001) and heated egg tolerance in those with baked egg tolerance (OR: 6.943, 95% CI: 1.554-31.017; p=0.011). Conclusions. Persistent hen`s egg allergy is characterized by multiple food allergies and age-related multimorbidities. Baked egg and heated egg yolk tolerance were more likely to be considered in a subgroup with a high expectation for finding a way to eliminate their allergy. https://turkjpediatr.org/article/view/2Hen`s eggadolescentsallergyatopic dermatitischildren |
| spellingShingle | Hilal Ünsal Sevda Tüten Dal Ayşegül Akarsu Ümit Murat Şahiner Özge Soyer Bülent Enis Şekerel Phenotypes of persistent hen`s egg allergy in children and adolescents The Turkish Journal of Pediatrics Hen`s egg adolescents allergy atopic dermatitis children |
| title | Phenotypes of persistent hen`s egg allergy in children and adolescents |
| title_full | Phenotypes of persistent hen`s egg allergy in children and adolescents |
| title_fullStr | Phenotypes of persistent hen`s egg allergy in children and adolescents |
| title_full_unstemmed | Phenotypes of persistent hen`s egg allergy in children and adolescents |
| title_short | Phenotypes of persistent hen`s egg allergy in children and adolescents |
| title_sort | phenotypes of persistent hen s egg allergy in children and adolescents |
| topic | Hen`s egg adolescents allergy atopic dermatitis children |
| url | https://turkjpediatr.org/article/view/2 |
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