Adaptive-optics scanning laser ophthalmoscopy study of non-arteritic anterior ischemic optic neuropathy
Objective: To investigate the changes in cone photoreceptors in patients with non-arteritic anterior ischemic optic neuropathy (NAION). Methods: Adaptive-optics scanning laser ophthalmoscopy (AO-SLO) was performed in patients with NAION and healthy participants. Acute NAION was defined as a disease...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100025002108 |
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| author | Wenting Gu Zizhong Hu Weijie Chen Qinghuai Liu Yonghui Gu |
| author_facet | Wenting Gu Zizhong Hu Weijie Chen Qinghuai Liu Yonghui Gu |
| author_sort | Wenting Gu |
| collection | DOAJ |
| description | Objective: To investigate the changes in cone photoreceptors in patients with non-arteritic anterior ischemic optic neuropathy (NAION). Methods: Adaptive-optics scanning laser ophthalmoscopy (AO-SLO) was performed in patients with NAION and healthy participants. Acute NAION was defined as a disease duration of <2 months, whereas chronic NAION was defined as a duration of >2 months. We analyzed four quadrants (superior, inferior, nasal, and temporal with respect to the central fovea of the macula) of the cone layer images at 2.4° × 2.4° collected at 3° eccentricity. Patients with NAION were further examined by using optical coherence tomography (OCT). Results: Significant differences were observed in peripapillary retinal nerve fiber layer and ganglion cell layer thicknesses between the normal and affected eyes (P < 0.05). The AO-SLO data of patients with monocular NAION showed no statistical differences in the density, regularity, and dispersion of cone cells in the superior, inferior, nasal, and temporal quadrants (P > 0.05). No significant differences were noted in the density among the healthy, acute NAION, and chronic NAION groups (P > 0.05). Conclusion: AO-SLO showed cone integrity in patients with NAION. From a microscopic perspective, NAION might not affect cone photoreceptors. |
| format | Article |
| id | doaj-art-80f5cb4d50b842308bde0cd8e1dc4c30 |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-80f5cb4d50b842308bde0cd8e1dc4c302025-08-20T03:44:58ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-08-015410467810.1016/j.pdpdt.2025.104678Adaptive-optics scanning laser ophthalmoscopy study of non-arteritic anterior ischemic optic neuropathyWenting Gu0Zizhong Hu1Weijie Chen2Qinghuai Liu3Yonghui Gu4Department of Ophthalmology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou 215008 Jiangsu, ChinaDepartment of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029 Jiangsu, ChinaDepartment of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029 Jiangsu, ChinaDepartment of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029 Jiangsu, ChinaDepartment of Ophthalmology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou 215008 Jiangsu, China; Corresponding author.Objective: To investigate the changes in cone photoreceptors in patients with non-arteritic anterior ischemic optic neuropathy (NAION). Methods: Adaptive-optics scanning laser ophthalmoscopy (AO-SLO) was performed in patients with NAION and healthy participants. Acute NAION was defined as a disease duration of <2 months, whereas chronic NAION was defined as a duration of >2 months. We analyzed four quadrants (superior, inferior, nasal, and temporal with respect to the central fovea of the macula) of the cone layer images at 2.4° × 2.4° collected at 3° eccentricity. Patients with NAION were further examined by using optical coherence tomography (OCT). Results: Significant differences were observed in peripapillary retinal nerve fiber layer and ganglion cell layer thicknesses between the normal and affected eyes (P < 0.05). The AO-SLO data of patients with monocular NAION showed no statistical differences in the density, regularity, and dispersion of cone cells in the superior, inferior, nasal, and temporal quadrants (P > 0.05). No significant differences were noted in the density among the healthy, acute NAION, and chronic NAION groups (P > 0.05). Conclusion: AO-SLO showed cone integrity in patients with NAION. From a microscopic perspective, NAION might not affect cone photoreceptors.http://www.sciencedirect.com/science/article/pii/S1572100025002108Non-arteritic anterior ischemic optic neuropathy (NAION)Cone photoreceptorsAdaptive-optics scanning laser ophthalmoscopy (AO-SLO)Optical coherence tomography (OCT) |
| spellingShingle | Wenting Gu Zizhong Hu Weijie Chen Qinghuai Liu Yonghui Gu Adaptive-optics scanning laser ophthalmoscopy study of non-arteritic anterior ischemic optic neuropathy Photodiagnosis and Photodynamic Therapy Non-arteritic anterior ischemic optic neuropathy (NAION) Cone photoreceptors Adaptive-optics scanning laser ophthalmoscopy (AO-SLO) Optical coherence tomography (OCT) |
| title | Adaptive-optics scanning laser ophthalmoscopy study of non-arteritic anterior ischemic optic neuropathy |
| title_full | Adaptive-optics scanning laser ophthalmoscopy study of non-arteritic anterior ischemic optic neuropathy |
| title_fullStr | Adaptive-optics scanning laser ophthalmoscopy study of non-arteritic anterior ischemic optic neuropathy |
| title_full_unstemmed | Adaptive-optics scanning laser ophthalmoscopy study of non-arteritic anterior ischemic optic neuropathy |
| title_short | Adaptive-optics scanning laser ophthalmoscopy study of non-arteritic anterior ischemic optic neuropathy |
| title_sort | adaptive optics scanning laser ophthalmoscopy study of non arteritic anterior ischemic optic neuropathy |
| topic | Non-arteritic anterior ischemic optic neuropathy (NAION) Cone photoreceptors Adaptive-optics scanning laser ophthalmoscopy (AO-SLO) Optical coherence tomography (OCT) |
| url | http://www.sciencedirect.com/science/article/pii/S1572100025002108 |
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