Identification and validation of pyroptosis-related genes in Alzheimer’s disease based on multi-transcriptome and machine learning

Identification and validation of pyroptosis-related genes in Alzheimer’s disease based on multi-transcriptome and machine learning

BackgroundAlzheimer’s disease (AD) progression is characterized by persistent neuroinflammation, where pyroptosis—an inflammatory programmed cell death mechanism—has emerged as a key pathological contributor. However, the molecular mechanisms through which pyroptosis-related genes (PRGs) drive AD pa...

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Bibliographic Details
Main Authors: Yuntai Wang, Yilin Li, Lu Zhou, Yihuan Yuan, Chuanfei Liu, Zimeng Zeng, Yuanqi Chen, Qi He, Zhuoze Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
pyroptosis
machine learning
bioinformatics
immune infiltration
regulatory network
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1568337/full
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