Continuous Renal Replacement Therapy for Severe Obstetric Sepsis
Objective: to improve the results of treatment for severe obstetric sepsis by pathogenetically founded continuous renal replacement therapies as extracorporeal homeostatic correction. Subjects and methods. Forty-two women with severe abdominal sepsis were divided into 3 groups: 1) 14 women with seve...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2010-04-01
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| Series: | Общая реаниматология |
| Online Access: | https://www.reanimatology.com/rmt/article/view/460 |
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| author | D. L. Shukevich D. K. Peredelkin Ye. V. Grigoryev A. S. Razumov Yu. A. Churlyaev L. E. Shukevich |
| author_facet | D. L. Shukevich D. K. Peredelkin Ye. V. Grigoryev A. S. Razumov Yu. A. Churlyaev L. E. Shukevich |
| author_sort | D. L. Shukevich |
| collection | DOAJ |
| description | Objective: to improve the results of treatment for severe obstetric sepsis by pathogenetically founded continuous renal replacement therapies as extracorporeal homeostatic correction. Subjects and methods. Forty-two women with severe abdominal sepsis were divided into 3 groups: 1) 14 women with severe extragenital abdominal sepsis who received standard intensive care (a control group); 2) 12 women with severe obstetric sepsis who had standard intensive care (a study group); 3) 16 with severe obstetric sepsis who had the standard intensive care supplemented with continuous renal replacement therapy (an intervention group). Results. In Group 2, endogenous intoxication and multiple organ dysfunction were controlled later than in Group 1, mortality rates being 41.7 and 7.1%, respectively. Clinical laboratory differences were due to gestosis recorded in 100% of the patients with severe obstetric sepsis. When continuous renal replacement therapy was incorporated into the complex therapy of severe obstetric sepsis, there was a prompter regression of endogenous intoxication and multiple organ dysfunction, mortality was decreased by an average of 35% as compared with that during standard therapy. Conclusion. The inclusion of continuous renal replacement therapy into the complex treatment program for severe obstetric sepsis made it possible to reduce control time _ for endogenous intoxication and multiple organ dysfunction and to decrease mortality by an average of 35% as compared with that during standard intensive care. Key words: obstetric sepsis, abdominal sepsis, gestosis, endogenous intoxication, multiple organ dysfunction, renal replacement therapy. |
| format | Article |
| id | doaj-art-80eb5892a6414e9fb3b38e112e31e672 |
| institution | DOAJ |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2010-04-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-80eb5892a6414e9fb3b38e112e31e6722025-08-20T02:55:52ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102010-04-016210.15360/1813-9779-2010-2-21460Continuous Renal Replacement Therapy for Severe Obstetric SepsisD. L. ShukevichD. K. PeredelkinYe. V. GrigoryevA. S. RazumovYu. A. ChurlyaevL. E. ShukevichObjective: to improve the results of treatment for severe obstetric sepsis by pathogenetically founded continuous renal replacement therapies as extracorporeal homeostatic correction. Subjects and methods. Forty-two women with severe abdominal sepsis were divided into 3 groups: 1) 14 women with severe extragenital abdominal sepsis who received standard intensive care (a control group); 2) 12 women with severe obstetric sepsis who had standard intensive care (a study group); 3) 16 with severe obstetric sepsis who had the standard intensive care supplemented with continuous renal replacement therapy (an intervention group). Results. In Group 2, endogenous intoxication and multiple organ dysfunction were controlled later than in Group 1, mortality rates being 41.7 and 7.1%, respectively. Clinical laboratory differences were due to gestosis recorded in 100% of the patients with severe obstetric sepsis. When continuous renal replacement therapy was incorporated into the complex therapy of severe obstetric sepsis, there was a prompter regression of endogenous intoxication and multiple organ dysfunction, mortality was decreased by an average of 35% as compared with that during standard therapy. Conclusion. The inclusion of continuous renal replacement therapy into the complex treatment program for severe obstetric sepsis made it possible to reduce control time _ for endogenous intoxication and multiple organ dysfunction and to decrease mortality by an average of 35% as compared with that during standard intensive care. Key words: obstetric sepsis, abdominal sepsis, gestosis, endogenous intoxication, multiple organ dysfunction, renal replacement therapy.https://www.reanimatology.com/rmt/article/view/460 |
| spellingShingle | D. L. Shukevich D. K. Peredelkin Ye. V. Grigoryev A. S. Razumov Yu. A. Churlyaev L. E. Shukevich Continuous Renal Replacement Therapy for Severe Obstetric Sepsis Общая реаниматология |
| title | Continuous Renal Replacement Therapy for Severe Obstetric Sepsis |
| title_full | Continuous Renal Replacement Therapy for Severe Obstetric Sepsis |
| title_fullStr | Continuous Renal Replacement Therapy for Severe Obstetric Sepsis |
| title_full_unstemmed | Continuous Renal Replacement Therapy for Severe Obstetric Sepsis |
| title_short | Continuous Renal Replacement Therapy for Severe Obstetric Sepsis |
| title_sort | continuous renal replacement therapy for severe obstetric sepsis |
| url | https://www.reanimatology.com/rmt/article/view/460 |
| work_keys_str_mv | AT dlshukevich continuousrenalreplacementtherapyforsevereobstetricsepsis AT dkperedelkin continuousrenalreplacementtherapyforsevereobstetricsepsis AT yevgrigoryev continuousrenalreplacementtherapyforsevereobstetricsepsis AT asrazumov continuousrenalreplacementtherapyforsevereobstetricsepsis AT yuachurlyaev continuousrenalreplacementtherapyforsevereobstetricsepsis AT leshukevich continuousrenalreplacementtherapyforsevereobstetricsepsis |