MOLECULAR-GENETIC «PORTRAIT» OF BREAST CANCER
Understanding genetic mechanisms and detection of biological markers of tumor growth forms an individual molecular phenotype oftransformed cells that characterizes stage of tumor, the ability to metastasize, hormonal sensitivity, chemotherapyefficiencyetc. Mutations in proto- and anti-oncogenes cont...
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| Format: | Article |
| Language: | Russian |
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Academician I.P. Pavlov First St. Petersburg State Medical University
2017-06-01
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| Series: | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
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| Online Access: | https://www.sci-notes.ru/jour/article/view/385 |
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| _version_ | 1849689621961637888 |
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| author | S. A. Laptiev M. A. Korzhenevskaia E. N. Imyanitov |
| author_facet | S. A. Laptiev M. A. Korzhenevskaia E. N. Imyanitov |
| author_sort | S. A. Laptiev |
| collection | DOAJ |
| description | Understanding genetic mechanisms and detection of biological markers of tumor growth forms an individual molecular phenotype oftransformed cells that characterizes stage of tumor, the ability to metastasize, hormonal sensitivity, chemotherapyefficiencyetc. Mutations in proto- and anti-oncogenes controlling mitotic activity of cells and their ability to DNA reparation are often found in tumor cells in patients with cancer. Defects of classical tumor suppressor genes (BRCA1/2, CHEK2, ATM, PALB2, NBS1, TP53, etc.) determine the hereditary predisposition to breast cancer caused by genomic instability and appearance of «chimeric» genes, aneuploidies and chromosomal aberrations. Breast cancer is a genetically heterogeneous disease with various molecular, biological and clinical features. Identificationof the molecular phenotype of breast carcinomas is an important prognostic factor of the disease, and it helps to individualize the therapeutic approach for patients. |
| format | Article |
| id | doaj-art-80e7e20ed2844a6e857cdb02f02e1176 |
| institution | DOAJ |
| issn | 1607-4181 2541-8807 |
| language | Russian |
| publishDate | 2017-06-01 |
| publisher | Academician I.P. Pavlov First St. Petersburg State Medical University |
| record_format | Article |
| series | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
| spelling | doaj-art-80e7e20ed2844a6e857cdb02f02e11762025-08-20T03:21:34ZrusAcademician I.P. Pavlov First St. Petersburg State Medical UniversityУчёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова1607-41812541-88072017-06-01242122210.24884/1607-4181-2017-24-2-12-22341MOLECULAR-GENETIC «PORTRAIT» OF BREAST CANCERS. A. Laptiev0M. A. Korzhenevskaia1E. N. Imyanitov2Federal State Budgetary Educational Institution of Higher Education «Academician I. P. Pavlov First St. Petersburg State Medical University» of the Ministry of Healthcare of the Russion FederationFederal State Budgetary Educational Institution of Higher Education «Academician I. P. Pavlov First St. Petersburg State Medical University» of the Ministry of Healthcare of the Russion FederationFSBI «N. N. Petrov Institute of Oncology» Ministry of Health of the Russian FederationUnderstanding genetic mechanisms and detection of biological markers of tumor growth forms an individual molecular phenotype oftransformed cells that characterizes stage of tumor, the ability to metastasize, hormonal sensitivity, chemotherapyefficiencyetc. Mutations in proto- and anti-oncogenes controlling mitotic activity of cells and their ability to DNA reparation are often found in tumor cells in patients with cancer. Defects of classical tumor suppressor genes (BRCA1/2, CHEK2, ATM, PALB2, NBS1, TP53, etc.) determine the hereditary predisposition to breast cancer caused by genomic instability and appearance of «chimeric» genes, aneuploidies and chromosomal aberrations. Breast cancer is a genetically heterogeneous disease with various molecular, biological and clinical features. Identificationof the molecular phenotype of breast carcinomas is an important prognostic factor of the disease, and it helps to individualize the therapeutic approach for patients.https://www.sci-notes.ru/jour/article/view/385breast cancerproto-oncogenesanti-oncogenesmolecular markers of tumor cellscancer predisposing mutations |
| spellingShingle | S. A. Laptiev M. A. Korzhenevskaia E. N. Imyanitov MOLECULAR-GENETIC «PORTRAIT» OF BREAST CANCER Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова breast cancer proto-oncogenes anti-oncogenes molecular markers of tumor cells cancer predisposing mutations |
| title | MOLECULAR-GENETIC «PORTRAIT» OF BREAST CANCER |
| title_full | MOLECULAR-GENETIC «PORTRAIT» OF BREAST CANCER |
| title_fullStr | MOLECULAR-GENETIC «PORTRAIT» OF BREAST CANCER |
| title_full_unstemmed | MOLECULAR-GENETIC «PORTRAIT» OF BREAST CANCER |
| title_short | MOLECULAR-GENETIC «PORTRAIT» OF BREAST CANCER |
| title_sort | molecular genetic portrait of breast cancer |
| topic | breast cancer proto-oncogenes anti-oncogenes molecular markers of tumor cells cancer predisposing mutations |
| url | https://www.sci-notes.ru/jour/article/view/385 |
| work_keys_str_mv | AT salaptiev moleculargeneticportraitofbreastcancer AT makorzhenevskaia moleculargeneticportraitofbreastcancer AT enimyanitov moleculargeneticportraitofbreastcancer |