Advances in two-photon absorption photodynamic therapy of glioma based on porphyrin-based metal-organicframework composites
Gliomas of the brain are characterised by high aggressiveness, high postoperative recurrence rate, high morbidity and mortality, posing a great challenge to clinical treatment. Traditional treatments include surgery, radiotherapy and chemotherapy; they also have significant associated side effects,...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-10-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100024003181 |
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| author | Yong-Tao Gao Jun-Hui Liu Kang He Shuang-lei Guo |
| author_facet | Yong-Tao Gao Jun-Hui Liu Kang He Shuang-lei Guo |
| author_sort | Yong-Tao Gao |
| collection | DOAJ |
| description | Gliomas of the brain are characterised by high aggressiveness, high postoperative recurrence rate, high morbidity and mortality, posing a great challenge to clinical treatment. Traditional treatments include surgery, radiotherapy and chemotherapy; they also have significant associated side effects, leading to difficulties in tumour resection and recurrence. Photodynamic therapy has been shown to be a promising new strategy to help treat malignant tumours of the brain. It irradiates the tumour site at a specific wavelength to activate a photosensitiser, which selectively accumulates at the tumour site, triggering a photochemical reaction that destroys the tumour cells. It has the advantages of being minimally invasive, highly targeted and with few adverse reactions, and is expected to be well used in anti-tumour therapy. However, the therapeutic effect of traditional PDT is limited by the weak tissue penetration ability of photosensitiser, hypoxia and immunosuppression in the tumour microenvironment. This paper reviews the current research status on the therapeutic principle of photodynamic therapy in glioma and the mechanism of tumour cell injury, and also analyses the advantages and disadvantages of the current application in glioma treatment, and clarifies the analysis of ideas to improve the tissue penetration ability of photosensitizers. It aims to provide a feasible direction for the improvement of photodynamic therapy for glioma and a reference for the clinical treatment of deep brain tumours. |
| format | Article |
| id | doaj-art-80e6b585ccd24b5a8ef1d6659ea66369 |
| institution | OA Journals |
| issn | 1572-1000 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-80e6b585ccd24b5a8ef1d6659ea663692025-08-20T01:47:59ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002024-10-014910428110.1016/j.pdpdt.2024.104281Advances in two-photon absorption photodynamic therapy of glioma based on porphyrin-based metal-organicframework compositesYong-Tao Gao0Jun-Hui Liu1Kang He2Shuang-lei Guo3Department of Neurosurgery, Huaihe Hospital of Henan University, Kaifeng City, Henan Province, PR China, 475000; Corresponding author at: Department of Neurosurgery, Huaihe Hospital of Henan University, Kaifeng City, Henan Province, PR China.School of Physics and Electronics, Henan University, Kaifeng City, Henan Province, PR China, 475004Department of Neurosurgery, Huaihe Hospital of Henan University, Kaifeng City, Henan Province, PR China, 475000Department of Neurosurgery, Huaihe Hospital of Henan University, Kaifeng City, Henan Province, PR China, 475000Gliomas of the brain are characterised by high aggressiveness, high postoperative recurrence rate, high morbidity and mortality, posing a great challenge to clinical treatment. Traditional treatments include surgery, radiotherapy and chemotherapy; they also have significant associated side effects, leading to difficulties in tumour resection and recurrence. Photodynamic therapy has been shown to be a promising new strategy to help treat malignant tumours of the brain. It irradiates the tumour site at a specific wavelength to activate a photosensitiser, which selectively accumulates at the tumour site, triggering a photochemical reaction that destroys the tumour cells. It has the advantages of being minimally invasive, highly targeted and with few adverse reactions, and is expected to be well used in anti-tumour therapy. However, the therapeutic effect of traditional PDT is limited by the weak tissue penetration ability of photosensitiser, hypoxia and immunosuppression in the tumour microenvironment. This paper reviews the current research status on the therapeutic principle of photodynamic therapy in glioma and the mechanism of tumour cell injury, and also analyses the advantages and disadvantages of the current application in glioma treatment, and clarifies the analysis of ideas to improve the tissue penetration ability of photosensitizers. It aims to provide a feasible direction for the improvement of photodynamic therapy for glioma and a reference for the clinical treatment of deep brain tumours.http://www.sciencedirect.com/science/article/pii/S1572100024003181PorphyrinTwo-photon absorptionPhotodynamic therapyGliomaTreatment |
| spellingShingle | Yong-Tao Gao Jun-Hui Liu Kang He Shuang-lei Guo Advances in two-photon absorption photodynamic therapy of glioma based on porphyrin-based metal-organicframework composites Photodiagnosis and Photodynamic Therapy Porphyrin Two-photon absorption Photodynamic therapy Glioma Treatment |
| title | Advances in two-photon absorption photodynamic therapy of glioma based on porphyrin-based metal-organicframework composites |
| title_full | Advances in two-photon absorption photodynamic therapy of glioma based on porphyrin-based metal-organicframework composites |
| title_fullStr | Advances in two-photon absorption photodynamic therapy of glioma based on porphyrin-based metal-organicframework composites |
| title_full_unstemmed | Advances in two-photon absorption photodynamic therapy of glioma based on porphyrin-based metal-organicframework composites |
| title_short | Advances in two-photon absorption photodynamic therapy of glioma based on porphyrin-based metal-organicframework composites |
| title_sort | advances in two photon absorption photodynamic therapy of glioma based on porphyrin based metal organicframework composites |
| topic | Porphyrin Two-photon absorption Photodynamic therapy Glioma Treatment |
| url | http://www.sciencedirect.com/science/article/pii/S1572100024003181 |
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