Polydatin exerts therapeutic effects on myelodysplastic syndrome by inhibiting the protein expression of oncogenes via hypermethylation in vitro

Polydatin exerts therapeutic effects on myelodysplastic syndrome by inhibiting the protein expression of oncogenes via hypermethylation in vitro

Abstract DNA methylation plays a critical role in myelodysplastic syndrome (MDS). Here, we aimed to observe the effects of polydatin (PD) on DNA methylation in MDS cells on a genome-wide scale and explore the underlying mechanisms, providing new evidence for PD as a novel hypermethylation agent. We...

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Bibliographic Details
Main Authors: Qingbing Zhou, Yuanbin Liang, Ruofan Chen, Hongzhi Wang, Qiuyue Guo, Li Liu, Xiaobo Zhu, Fengqin Xu
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Myelodysplastic syndrome
Polydatin
Oncogene
Hypermethylation
Hypomethylation
Online Access:https://doi.org/10.1038/s41598-025-01867-6
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