Atypical peripheral actin band formation via overactivation of RhoA and nonmuscle myosin II in mitofusin 2-deficient cells

Atypical peripheral actin band formation via overactivation of RhoA and nonmuscle myosin II in mitofusin 2-deficient cells

Cell spreading and migration play central roles in many physiological and pathophysiological processes. We have previously shown that MFN2 regulates the migration of human neutrophil-like cells via suppressing Rac activation. Here, we show that in mouse embryonic fibroblasts, MFN2 suppresses RhoA ac...

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Bibliographic Details
Main Authors: Yueyang Wang, Lee D Troughton, Fan Xu, Aritra Chatterjee, Chang Ding, Han Zhao, Laura Pulido Cifuentes, Ryan B Wagner, Tianqi Wang, Shelly Tan, Jingjuan Chen, Linlin Li, David Umulis, Shihuan Kuang, Daniel M Suter, Chongli Yuan, Deva Chan, Fang Huang, Patrick W Oakes, Qing Deng
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-09-01
Series:eLife
Subjects:
cell spreading
cell migration
mitochondrial-ER tether
Rho GTPase
calcium signaling
mouse embryonic fibroblasts
Online Access:https://elifesciences.org/articles/88828
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