High dose-rate brachytherapy of localized prostate cancer converts tumors from cold to hot

High dose-rate brachytherapy of localized prostate cancer converts tumors from cold to hot

Background Prostate cancer (PCa) has a profoundly immunosuppressive microenvironment and is commonly immune excluded with few infiltrative lymphocytes and low levels of immune activation. High-dose radiation has been demonstrated to stimulate the immune system in various human solid tumors. We hypot...

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Main Authors: Shahneen Sandhu, Paul J Neeson, Simon P Keam, Heloise Halse, Thu Nguyen, Minyu Wang, Nicolas Van Kooten Losio, Catherine Mitchell, Franco Caramia, David J Byrne, Sue Haupt, Georgina Ryland, Phillip K Darcy, Piers Blombery, Ygal Haupt, Scott G Williams
Format: Article
Language:English
Published: BMJ Publishing Group 2020-05-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/8/1/e000792.full
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