Process Analytical Technology Obtained Metastable Zone Width, Nucleation Rate and Solubility of Paracetamol in Isopropanol—Theoretical Analysis

Process Analytical Technology Obtained Metastable Zone Width, Nucleation Rate and Solubility of Paracetamol in Isopropanol—Theoretical Analysis

<b>Background:</b> Metastable zone width (MSZW) and solubility are crucial for developing crystallization procedures in the purification of active pharmaceutical ingredients (APIs). Traditionally, determining these properties involves labor-intensive methods that can take weeks or even m...

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Bibliographic Details
Main Authors: Mahmoud Ranjbar, Mayank Vashishtha, Gavin Walker, K. Vasanth Kumar
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Pharmaceuticals
Subjects:
crystallization
kinetics
metastable zone width
PAT
thermodynamics
nucleation
Online Access:https://www.mdpi.com/1424-8247/18/3/314
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