Use of phosphodiesterase 4 inhibitor in patients with psoriatic arthritis
Psoriatic arthritis (PsA) is a chronic inflammatory disease of the joints, spine, and entheses, which is associated with psoriasis. The pathological process is localized mainly in the tissues of the locomotor system and leads to the development of erosive arthritis, intra-articular osteolysis, and s...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
IMA-PRESS LLC
2017-04-01
|
| Series: | Современная ревматология |
| Subjects: | |
| Online Access: | https://mrj.ima-press.net/mrj/article/view/759 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850023490253488128 |
|---|---|
| author | V. I. Mazurov E. A. Trofimov |
| author_facet | V. I. Mazurov E. A. Trofimov |
| author_sort | V. I. Mazurov |
| collection | DOAJ |
| description | Psoriatic arthritis (PsA) is a chronic inflammatory disease of the joints, spine, and entheses, which is associated with psoriasis. The pathological process is localized mainly in the tissues of the locomotor system and leads to the development of erosive arthritis, intra-articular osteolysis, and spondyloarthritis. Nonsteroidal anti-inflammatory drugs, glucocorticoids, disease-modifying antirheumatic drugs (DMARDs), biological agents (BAs), and targeted synthetic drugs (or signaling pathway blockers) are used to treat PsA. The latter group of drugs includes apremilast, a phosphodiesterase 4 inhibitor. Recent data of controlled studies suggest that apremilast is effective and safe in treating psoriasis and PsA. Prospects for the use of apremilast in PsA are associated with the possibility of giving the drug to patients because of the inefficacy of DMARDs or BAs. |
| format | Article |
| id | doaj-art-80cc487e56e7498da7535f93ef7ed36d |
| institution | DOAJ |
| issn | 1996-7012 2310-158X |
| language | Russian |
| publishDate | 2017-04-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj-art-80cc487e56e7498da7535f93ef7ed36d2025-08-20T03:01:22ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2017-04-01112757910.14412/1996-7012-2017-2-75-792038Use of phosphodiesterase 4 inhibitor in patients with psoriatic arthritisV. I. Mazurov0E. A. Trofimov1I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint PetersburgI.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia, Saint PetersburgPsoriatic arthritis (PsA) is a chronic inflammatory disease of the joints, spine, and entheses, which is associated with psoriasis. The pathological process is localized mainly in the tissues of the locomotor system and leads to the development of erosive arthritis, intra-articular osteolysis, and spondyloarthritis. Nonsteroidal anti-inflammatory drugs, glucocorticoids, disease-modifying antirheumatic drugs (DMARDs), biological agents (BAs), and targeted synthetic drugs (or signaling pathway blockers) are used to treat PsA. The latter group of drugs includes apremilast, a phosphodiesterase 4 inhibitor. Recent data of controlled studies suggest that apremilast is effective and safe in treating psoriasis and PsA. Prospects for the use of apremilast in PsA are associated with the possibility of giving the drug to patients because of the inefficacy of DMARDs or BAs.https://mrj.ima-press.net/mrj/article/view/759psoriasispsoriatic arthritisapremilastphosphodiesterasetargeted therapy |
| spellingShingle | V. I. Mazurov E. A. Trofimov Use of phosphodiesterase 4 inhibitor in patients with psoriatic arthritis Современная ревматология psoriasis psoriatic arthritis apremilast phosphodiesterase targeted therapy |
| title | Use of phosphodiesterase 4 inhibitor in patients with psoriatic arthritis |
| title_full | Use of phosphodiesterase 4 inhibitor in patients with psoriatic arthritis |
| title_fullStr | Use of phosphodiesterase 4 inhibitor in patients with psoriatic arthritis |
| title_full_unstemmed | Use of phosphodiesterase 4 inhibitor in patients with psoriatic arthritis |
| title_short | Use of phosphodiesterase 4 inhibitor in patients with psoriatic arthritis |
| title_sort | use of phosphodiesterase 4 inhibitor in patients with psoriatic arthritis |
| topic | psoriasis psoriatic arthritis apremilast phosphodiesterase targeted therapy |
| url | https://mrj.ima-press.net/mrj/article/view/759 |
| work_keys_str_mv | AT vimazurov useofphosphodiesterase4inhibitorinpatientswithpsoriaticarthritis AT eatrofimov useofphosphodiesterase4inhibitorinpatientswithpsoriaticarthritis |