Genetic Susceptibility to Type 2 Diabetes, Television Viewing, and Atherosclerotic Cardiovascular Disease Risk
Background Type 2 diabetes (T2D) is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). This study examined the interplay between watching television and T2D genetic risk for risk of ASCVD. Methods We included 346 916 White British individuals from UK Biobank. A weighted polygeni...
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| Format: | Article |
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Wiley
2025-03-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
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| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.124.036811 |
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| author | Mengyao Wang Paul James Collings Felix R. Day Ken K. Ong Soren Brage Stephen J. Sharp Haeyoon Jang Siyeon Suh Shan Luo Shiu Lun Au Yeung Youngwon Kim |
| author_facet | Mengyao Wang Paul James Collings Felix R. Day Ken K. Ong Soren Brage Stephen J. Sharp Haeyoon Jang Siyeon Suh Shan Luo Shiu Lun Au Yeung Youngwon Kim |
| author_sort | Mengyao Wang |
| collection | DOAJ |
| description | Background Type 2 diabetes (T2D) is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). This study examined the interplay between watching television and T2D genetic risk for risk of ASCVD. Methods We included 346 916 White British individuals from UK Biobank. A weighted polygenic risk score for T2D was calculated on the basis of 138 genetic variants associated with T2D. Time spent watching television was self‐reported and categorized into 2 groups: ≤1 h/d and ≥2 h/d. Over a median 13.8‐year follow‐up, 21 265 incident ASCVD events were identified. Models using Cox regression with age as the underlying time scale adjusted for potential confounders (demographic, anthropometric, lifestyle factors, and medication use) were fit. Results Compared with watching television for ≤1 h/d, watching ≥2 h/d was associated with 12% (95% CI, 1.07–1.16) higher hazards of ASCVD, independently of T2D genetic risk. Joint analyses (with low T2D genetic risk and ≤1 h/d of television viewing as reference) indicated that medium and high T2D genetic risk was not associated with higher hazards of ASCVD as long as television viewing was ≤1 h/d. The P values for multiplicative and additive interactions between T2D genetic risk and television viewing were 0.050 and 0.038, respectively. The 10‐year absolute risk of ASCVD was lower for high T2D genetic risk combined with ≤1 h/d of television viewing (2.13%) than for low T2D genetic risk combined with ≥2 h/d of television viewing (2.46%). Conclusions Future clinical trials of lifestyle‐modification interventions targeting specific types of screen‐based sedentary activities could be implemented to individuals at high genetic risk of T2D for primary prevention of ASCVD. |
| format | Article |
| id | doaj-art-80c8ef9d259b4e3588f0d70a792141e6 |
| institution | Kabale University |
| issn | 2047-9980 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj-art-80c8ef9d259b4e3588f0d70a792141e62025-08-20T03:24:47ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802025-03-0114610.1161/JAHA.124.036811Genetic Susceptibility to Type 2 Diabetes, Television Viewing, and Atherosclerotic Cardiovascular Disease RiskMengyao Wang0Paul James Collings1Felix R. Day2Ken K. Ong3Soren Brage4Stephen J. Sharp5Haeyoon Jang6Siyeon Suh7Shan Luo8Shiu Lun Au Yeung9Youngwon Kim10School of Public Health The University of Hong Kong Li Ka Shing Faculty of Medicine Hong Kong SAR ChinaSchool of Public Health The University of Hong Kong Li Ka Shing Faculty of Medicine Hong Kong SAR ChinaMRC Epidemiology Unit Institute of Metabolic Science, University of Cambridge Cambridge Cambridgeshire United KingdomMRC Epidemiology Unit Institute of Metabolic Science, University of Cambridge Cambridge Cambridgeshire United KingdomMRC Epidemiology Unit Institute of Metabolic Science, University of Cambridge Cambridge Cambridgeshire United KingdomMRC Epidemiology Unit Institute of Metabolic Science, University of Cambridge Cambridge Cambridgeshire United KingdomSchool of Public Health The University of Hong Kong Li Ka Shing Faculty of Medicine Hong Kong SAR ChinaSchool of Public Health The University of Hong Kong Li Ka Shing Faculty of Medicine Hong Kong SAR ChinaSchool of Public Health The University of Hong Kong Li Ka Shing Faculty of Medicine Hong Kong SAR ChinaSchool of Public Health The University of Hong Kong Li Ka Shing Faculty of Medicine Hong Kong SAR ChinaSchool of Public Health The University of Hong Kong Li Ka Shing Faculty of Medicine Hong Kong SAR ChinaBackground Type 2 diabetes (T2D) is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). This study examined the interplay between watching television and T2D genetic risk for risk of ASCVD. Methods We included 346 916 White British individuals from UK Biobank. A weighted polygenic risk score for T2D was calculated on the basis of 138 genetic variants associated with T2D. Time spent watching television was self‐reported and categorized into 2 groups: ≤1 h/d and ≥2 h/d. Over a median 13.8‐year follow‐up, 21 265 incident ASCVD events were identified. Models using Cox regression with age as the underlying time scale adjusted for potential confounders (demographic, anthropometric, lifestyle factors, and medication use) were fit. Results Compared with watching television for ≤1 h/d, watching ≥2 h/d was associated with 12% (95% CI, 1.07–1.16) higher hazards of ASCVD, independently of T2D genetic risk. Joint analyses (with low T2D genetic risk and ≤1 h/d of television viewing as reference) indicated that medium and high T2D genetic risk was not associated with higher hazards of ASCVD as long as television viewing was ≤1 h/d. The P values for multiplicative and additive interactions between T2D genetic risk and television viewing were 0.050 and 0.038, respectively. The 10‐year absolute risk of ASCVD was lower for high T2D genetic risk combined with ≤1 h/d of television viewing (2.13%) than for low T2D genetic risk combined with ≥2 h/d of television viewing (2.46%). Conclusions Future clinical trials of lifestyle‐modification interventions targeting specific types of screen‐based sedentary activities could be implemented to individuals at high genetic risk of T2D for primary prevention of ASCVD.https://www.ahajournals.org/doi/10.1161/JAHA.124.036811atherosclerotic cardiovascular diseasegenetic susceptibilityscreen‐based sedentary activitiestype 2 diabetes |
| spellingShingle | Mengyao Wang Paul James Collings Felix R. Day Ken K. Ong Soren Brage Stephen J. Sharp Haeyoon Jang Siyeon Suh Shan Luo Shiu Lun Au Yeung Youngwon Kim Genetic Susceptibility to Type 2 Diabetes, Television Viewing, and Atherosclerotic Cardiovascular Disease Risk Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease atherosclerotic cardiovascular disease genetic susceptibility screen‐based sedentary activities type 2 diabetes |
| title | Genetic Susceptibility to Type 2 Diabetes, Television Viewing, and Atherosclerotic Cardiovascular Disease Risk |
| title_full | Genetic Susceptibility to Type 2 Diabetes, Television Viewing, and Atherosclerotic Cardiovascular Disease Risk |
| title_fullStr | Genetic Susceptibility to Type 2 Diabetes, Television Viewing, and Atherosclerotic Cardiovascular Disease Risk |
| title_full_unstemmed | Genetic Susceptibility to Type 2 Diabetes, Television Viewing, and Atherosclerotic Cardiovascular Disease Risk |
| title_short | Genetic Susceptibility to Type 2 Diabetes, Television Viewing, and Atherosclerotic Cardiovascular Disease Risk |
| title_sort | genetic susceptibility to type 2 diabetes television viewing and atherosclerotic cardiovascular disease risk |
| topic | atherosclerotic cardiovascular disease genetic susceptibility screen‐based sedentary activities type 2 diabetes |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.124.036811 |
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