FAPi PET/CT Imaging to Identify Fibrosis in Immune-Mediated Inflammatory Diseases
Immune-mediated inflammatory diseases (IMIDs) are characterized by chronic systemic inflammation and multi-organ involvement. Fibrosis formation in IMIDs can cause tissue destruction and subsequently organ malfunction. Fibroblast activation protein inhibitor positron emission tomography/computed tom...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/13/4/775 |
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| author | Dalia A. Lartey Lynn A. Schilder Gerben J. C. Zwezerijnen Geert R. A. M. D’Haens Joep Grootjans Mark Löwenberg |
| author_facet | Dalia A. Lartey Lynn A. Schilder Gerben J. C. Zwezerijnen Geert R. A. M. D’Haens Joep Grootjans Mark Löwenberg |
| author_sort | Dalia A. Lartey |
| collection | DOAJ |
| description | Immune-mediated inflammatory diseases (IMIDs) are characterized by chronic systemic inflammation and multi-organ involvement. Fibrosis formation in IMIDs can cause tissue destruction and subsequently organ malfunction. Fibroblast activation protein inhibitor positron emission tomography/computed tomography (FAPi PET/CT) represents a novel imaging technique that holds great potential to visualize in vivo fibrosis. We here provide an overview of available evidence on FAPi PET/CT imaging to visualize fibrosis in various IMIDs, including interstitial lung diseases, immunoglobulin G4-related diseases, cardiovascular diseases, kidney diseases, and gastrointestinal diseases. FAPi PET/CT imaging demonstrates high sensitivity in detecting early fibrosis, correlating with disease severity, across different IMIDs, showing superiority compared to conventional imaging modalities. Although FAPi PET/CT might be a useful tool to assess fibrosis formation, thereby aiding in grading disease severity and staging, future studies should include larger sample sizes in a broad variety of IMIDs with emphasis on the optimization of imaging protocols to further validate its diagnostic value. |
| format | Article |
| id | doaj-art-80c800dfe46745e8b47079a2cdd122ad |
| institution | DOAJ |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-80c800dfe46745e8b47079a2cdd122ad2025-08-20T03:14:17ZengMDPI AGBiomedicines2227-90592025-03-0113477510.3390/biomedicines13040775FAPi PET/CT Imaging to Identify Fibrosis in Immune-Mediated Inflammatory DiseasesDalia A. Lartey0Lynn A. Schilder1Gerben J. C. Zwezerijnen2Geert R. A. M. D’Haens3Joep Grootjans4Mark Löwenberg5Laboratory of Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam University Medical Centers, 1081 BT Amsterdam, The NetherlandsDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Centers, 1081 HV Amsterdam, The NetherlandsDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, 1081 HV Amsterdam, The NetherlandsDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Centers, 1081 HV Amsterdam, The NetherlandsLaboratory of Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam University Medical Centers, 1081 BT Amsterdam, The NetherlandsDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Centers, 1081 HV Amsterdam, The NetherlandsImmune-mediated inflammatory diseases (IMIDs) are characterized by chronic systemic inflammation and multi-organ involvement. Fibrosis formation in IMIDs can cause tissue destruction and subsequently organ malfunction. Fibroblast activation protein inhibitor positron emission tomography/computed tomography (FAPi PET/CT) represents a novel imaging technique that holds great potential to visualize in vivo fibrosis. We here provide an overview of available evidence on FAPi PET/CT imaging to visualize fibrosis in various IMIDs, including interstitial lung diseases, immunoglobulin G4-related diseases, cardiovascular diseases, kidney diseases, and gastrointestinal diseases. FAPi PET/CT imaging demonstrates high sensitivity in detecting early fibrosis, correlating with disease severity, across different IMIDs, showing superiority compared to conventional imaging modalities. Although FAPi PET/CT might be a useful tool to assess fibrosis formation, thereby aiding in grading disease severity and staging, future studies should include larger sample sizes in a broad variety of IMIDs with emphasis on the optimization of imaging protocols to further validate its diagnostic value.https://www.mdpi.com/2227-9059/13/4/775fibrosisimmune-mediated inflammatory diseases (IMIDs)FAPi PET/CTfibroblast activation protein (FAP)positron emission tomography imaging |
| spellingShingle | Dalia A. Lartey Lynn A. Schilder Gerben J. C. Zwezerijnen Geert R. A. M. D’Haens Joep Grootjans Mark Löwenberg FAPi PET/CT Imaging to Identify Fibrosis in Immune-Mediated Inflammatory Diseases Biomedicines fibrosis immune-mediated inflammatory diseases (IMIDs) FAPi PET/CT fibroblast activation protein (FAP) positron emission tomography imaging |
| title | FAPi PET/CT Imaging to Identify Fibrosis in Immune-Mediated Inflammatory Diseases |
| title_full | FAPi PET/CT Imaging to Identify Fibrosis in Immune-Mediated Inflammatory Diseases |
| title_fullStr | FAPi PET/CT Imaging to Identify Fibrosis in Immune-Mediated Inflammatory Diseases |
| title_full_unstemmed | FAPi PET/CT Imaging to Identify Fibrosis in Immune-Mediated Inflammatory Diseases |
| title_short | FAPi PET/CT Imaging to Identify Fibrosis in Immune-Mediated Inflammatory Diseases |
| title_sort | fapi pet ct imaging to identify fibrosis in immune mediated inflammatory diseases |
| topic | fibrosis immune-mediated inflammatory diseases (IMIDs) FAPi PET/CT fibroblast activation protein (FAP) positron emission tomography imaging |
| url | https://www.mdpi.com/2227-9059/13/4/775 |
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