Gender Differences in Ghrelin Association with Cardiometabolic Risk Factors in Arab Population
Ghrelin is a stomach produced hormone that has been shown to have protective role against development of CVD which is a leading cause of death in the Arab world. The objective of this study is to examine the gender difference in association between traditional CVD risk factors and plasma ghrelin amo...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/730472 |
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| author | Mohamed Abu-Farha Mohammed Dehbi Fiona Noronha Ali Tiss Monira Alarouj Kazem Behbehani Abdullah Bennakhi Naser Elkum |
| author_facet | Mohamed Abu-Farha Mohammed Dehbi Fiona Noronha Ali Tiss Monira Alarouj Kazem Behbehani Abdullah Bennakhi Naser Elkum |
| author_sort | Mohamed Abu-Farha |
| collection | DOAJ |
| description | Ghrelin is a stomach produced hormone that has been shown to have protective role against development of CVD which is a leading cause of death in the Arab world. The objective of this study is to examine the gender difference in association between traditional CVD risk factors and plasma ghrelin among Arabs. 359 Arab residents in Kuwait participated in a cross-sectional survey (≥20 years old): 191 were females and 168 were males. Plasma level of ghrelin was assessed using Luminex-based assay. Ghrelin levels were significantly higher in females (935 ± 78 pg/mL) than males (763 ± 65 pg/mL) (P=0.0007). Females showed inverse association with WC (r=-0.23, P=0.001) and HbA1C (r=-0.19, P=0.0102) as well as SBP (r=-0.15, P=0.0383) and DBP (r=-0.16, P=0.0230), respectively. Higher levels of ghrelin were shown to associate with increased insulin resistance, as measured by HOMAIR, in male Arab subjects (P-trend = 0.0202) but not in females. In this study we show that higher ghrelin level was negatively associated with measures of obesity, HbA1C, and blood pressure in females and positively associated with increased insulin resistance in Arab males. |
| format | Article |
| id | doaj-art-80c358eb4a994e7fa038da7f414f5faa |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-80c358eb4a994e7fa038da7f414f5faa2025-02-03T07:25:23ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/730472730472Gender Differences in Ghrelin Association with Cardiometabolic Risk Factors in Arab PopulationMohamed Abu-Farha0Mohammed Dehbi1Fiona Noronha2Ali Tiss3Monira Alarouj4Kazem Behbehani5Abdullah Bennakhi6Naser Elkum7Biochemistry and Molecular Biology Unit, Dasman Diabetes Institute, P.O. Box 1180, Kuwait City, KuwaitDiabetes Research Center, Qatar Biomedical Research Institute, P.O. Box 5825, Doha, QatarBiostatistics and Epidemiology Department, Dasman Diabetes Institute, P.O. Box 1180, Kuwait City, KuwaitBiochemistry and Molecular Biology Unit, Dasman Diabetes Institute, P.O. Box 1180, Kuwait City, KuwaitDasman Diabetes Institute, P.O. Box 1180, Kuwait City, KuwaitDasman Diabetes Institute, P.O. Box 1180, Kuwait City, KuwaitDasman Diabetes Institute, P.O. Box 1180, Kuwait City, KuwaitBiostatistics and Epidemiology Department, Dasman Diabetes Institute, P.O. Box 1180, Kuwait City, KuwaitGhrelin is a stomach produced hormone that has been shown to have protective role against development of CVD which is a leading cause of death in the Arab world. The objective of this study is to examine the gender difference in association between traditional CVD risk factors and plasma ghrelin among Arabs. 359 Arab residents in Kuwait participated in a cross-sectional survey (≥20 years old): 191 were females and 168 were males. Plasma level of ghrelin was assessed using Luminex-based assay. Ghrelin levels were significantly higher in females (935 ± 78 pg/mL) than males (763 ± 65 pg/mL) (P=0.0007). Females showed inverse association with WC (r=-0.23, P=0.001) and HbA1C (r=-0.19, P=0.0102) as well as SBP (r=-0.15, P=0.0383) and DBP (r=-0.16, P=0.0230), respectively. Higher levels of ghrelin were shown to associate with increased insulin resistance, as measured by HOMAIR, in male Arab subjects (P-trend = 0.0202) but not in females. In this study we show that higher ghrelin level was negatively associated with measures of obesity, HbA1C, and blood pressure in females and positively associated with increased insulin resistance in Arab males.http://dx.doi.org/10.1155/2014/730472 |
| spellingShingle | Mohamed Abu-Farha Mohammed Dehbi Fiona Noronha Ali Tiss Monira Alarouj Kazem Behbehani Abdullah Bennakhi Naser Elkum Gender Differences in Ghrelin Association with Cardiometabolic Risk Factors in Arab Population International Journal of Endocrinology |
| title | Gender Differences in Ghrelin Association with Cardiometabolic Risk Factors in Arab Population |
| title_full | Gender Differences in Ghrelin Association with Cardiometabolic Risk Factors in Arab Population |
| title_fullStr | Gender Differences in Ghrelin Association with Cardiometabolic Risk Factors in Arab Population |
| title_full_unstemmed | Gender Differences in Ghrelin Association with Cardiometabolic Risk Factors in Arab Population |
| title_short | Gender Differences in Ghrelin Association with Cardiometabolic Risk Factors in Arab Population |
| title_sort | gender differences in ghrelin association with cardiometabolic risk factors in arab population |
| url | http://dx.doi.org/10.1155/2014/730472 |
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