Low, rather than High, Body Mass Index Is a Risk Factor for Acute Kidney Injury in Multiethnic Asian Patients: A Retrospective Observational Study
Background. Acute kidney injury (AKI) is common in hospitalised patients. The relationship between body mass index (BMI) and the risk of having AKI for patients in the acute hospital setting is not known, particularly in the Asian population. Methods. This was a retrospective, single-centre, observa...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2018/3284612 |
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| author | Allen Yan Lun Liu Jiexun Wang Milind Nikam Boon Cheok Lai Lee Ying Yeoh |
| author_facet | Allen Yan Lun Liu Jiexun Wang Milind Nikam Boon Cheok Lai Lee Ying Yeoh |
| author_sort | Allen Yan Lun Liu |
| collection | DOAJ |
| description | Background. Acute kidney injury (AKI) is common in hospitalised patients. The relationship between body mass index (BMI) and the risk of having AKI for patients in the acute hospital setting is not known, particularly in the Asian population. Methods. This was a retrospective, single-centre, observational study conducted in Singapore, a multiethnic population. All patients aged ≥21 years and hospitalised from January to December 2013 were recruited. Results. A total of 12,555 patients were eligible for the analysis. A BMI of <18.5 kg/m2 was independently associated with the development of AKI in hospitalised patients (odds ratio (OR): 1.23 [95% confidence interval [CI]: 1.04–1.44, P=0.01]) but not for overweight and obesity. Subgroup analysis further revealed that underweight patients aged ≥75 and repeated hospitalisation posed a higher risk of AKI (OR: 1.25 [CI: 1.01–1.56], P=0.04; OR: 1.23 [CI: 1.04–1.44], P=0.01, resp.). Analyses by interactions between different age groups and BMI using continuous or categorised variables did not affect the overall probability of developing AKI. Conclusions. Underweight Asian patients are susceptible to AKI in acute hospital settings. Identification of this novel risk factor for AKI allows us to optimise patient care by prevention, early detection, and timely intervention. |
| format | Article |
| id | doaj-art-80beb5b37e1744d08f6f61aca4a4e85f |
| institution | OA Journals |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-80beb5b37e1744d08f6f61aca4a4e85f2025-08-20T02:08:50ZengWileyInternational Journal of Nephrology2090-214X2090-21582018-01-01201810.1155/2018/32846123284612Low, rather than High, Body Mass Index Is a Risk Factor for Acute Kidney Injury in Multiethnic Asian Patients: A Retrospective Observational StudyAllen Yan Lun Liu0Jiexun Wang1Milind Nikam2Boon Cheok Lai3Lee Ying Yeoh4Division of Renal Medicine, Department of General Medicine, Khoo Teck Puat Hospital, SingaporeClinical Research Unit, Khoo Teck Puat Hospital, SingaporeFresenius Medical Care Pte. Ltd., SingaporeDivision of Renal Medicine, Department of General Medicine, Khoo Teck Puat Hospital, SingaporeDivision of Renal Medicine, Department of General Medicine, Khoo Teck Puat Hospital, SingaporeBackground. Acute kidney injury (AKI) is common in hospitalised patients. The relationship between body mass index (BMI) and the risk of having AKI for patients in the acute hospital setting is not known, particularly in the Asian population. Methods. This was a retrospective, single-centre, observational study conducted in Singapore, a multiethnic population. All patients aged ≥21 years and hospitalised from January to December 2013 were recruited. Results. A total of 12,555 patients were eligible for the analysis. A BMI of <18.5 kg/m2 was independently associated with the development of AKI in hospitalised patients (odds ratio (OR): 1.23 [95% confidence interval [CI]: 1.04–1.44, P=0.01]) but not for overweight and obesity. Subgroup analysis further revealed that underweight patients aged ≥75 and repeated hospitalisation posed a higher risk of AKI (OR: 1.25 [CI: 1.01–1.56], P=0.04; OR: 1.23 [CI: 1.04–1.44], P=0.01, resp.). Analyses by interactions between different age groups and BMI using continuous or categorised variables did not affect the overall probability of developing AKI. Conclusions. Underweight Asian patients are susceptible to AKI in acute hospital settings. Identification of this novel risk factor for AKI allows us to optimise patient care by prevention, early detection, and timely intervention.http://dx.doi.org/10.1155/2018/3284612 |
| spellingShingle | Allen Yan Lun Liu Jiexun Wang Milind Nikam Boon Cheok Lai Lee Ying Yeoh Low, rather than High, Body Mass Index Is a Risk Factor for Acute Kidney Injury in Multiethnic Asian Patients: A Retrospective Observational Study International Journal of Nephrology |
| title | Low, rather than High, Body Mass Index Is a Risk Factor for Acute Kidney Injury in Multiethnic Asian Patients: A Retrospective Observational Study |
| title_full | Low, rather than High, Body Mass Index Is a Risk Factor for Acute Kidney Injury in Multiethnic Asian Patients: A Retrospective Observational Study |
| title_fullStr | Low, rather than High, Body Mass Index Is a Risk Factor for Acute Kidney Injury in Multiethnic Asian Patients: A Retrospective Observational Study |
| title_full_unstemmed | Low, rather than High, Body Mass Index Is a Risk Factor for Acute Kidney Injury in Multiethnic Asian Patients: A Retrospective Observational Study |
| title_short | Low, rather than High, Body Mass Index Is a Risk Factor for Acute Kidney Injury in Multiethnic Asian Patients: A Retrospective Observational Study |
| title_sort | low rather than high body mass index is a risk factor for acute kidney injury in multiethnic asian patients a retrospective observational study |
| url | http://dx.doi.org/10.1155/2018/3284612 |
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