Applications of Diquafosol Sodium in Ophthalmology: A Comprehensive Review of Therapeutic Utility
Diquafosol sodium is a purinergic P2Y<sub>2</sub> receptor agonist that is garnering much interest for its potential therapeutic benefits in ocular surface management. This review provides a comprehensive analysis of diquafosol’s pharmacology, clinical effectiveness, and role in the evol...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-03-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/15/3/484 |
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| author | Chelsea Qiu Lin Tan Duoduo Wu Xin Yun Toh Blanche Xiaohong Lim Kendrick Co Shih Louis Tong Chris Hong Long Lim |
| author_facet | Chelsea Qiu Lin Tan Duoduo Wu Xin Yun Toh Blanche Xiaohong Lim Kendrick Co Shih Louis Tong Chris Hong Long Lim |
| author_sort | Chelsea Qiu Lin Tan |
| collection | DOAJ |
| description | Diquafosol sodium is a purinergic P2Y<sub>2</sub> receptor agonist that is garnering much interest for its potential therapeutic benefits in ocular surface management. This review provides a comprehensive analysis of diquafosol’s pharmacology, clinical effectiveness, and role in the evolving landscape of ocular surface management. Future research should focus on optimising formulations, treatment duration, and exploring potential combination therapies to maximise therapeutic outcomes. By targeting underlying pathophysiological mechanisms, diquafosol represents a significant advancement in ocular surface management and a valuable addition to existing therapies. |
| format | Article |
| id | doaj-art-80be1261348a4e1e94beec3b2ac6e1b2 |
| institution | OA Journals |
| issn | 2075-1729 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj-art-80be1261348a4e1e94beec3b2ac6e1b22025-08-20T01:49:00ZengMDPI AGLife2075-17292025-03-0115348410.3390/life15030484Applications of Diquafosol Sodium in Ophthalmology: A Comprehensive Review of Therapeutic UtilityChelsea Qiu Lin Tan0Duoduo Wu1Xin Yun Toh2Blanche Xiaohong Lim3Kendrick Co Shih4Louis Tong5Chris Hong Long Lim6Department of Ophthalmology, National University Hospital, Singapore 119228, SingaporeDepartment of Ophthalmology, National University Hospital, Singapore 119228, SingaporeLee Kong Chian School of Medicine, National Technological University, Singapore 308232, SingaporeDepartment of Ophthalmology, National University Hospital, Singapore 119228, SingaporeDepartment of Ophthalmology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, ChinaLee Kong Chian School of Medicine, National Technological University, Singapore 308232, SingaporeDepartment of Ophthalmology, National University Hospital, Singapore 119228, SingaporeDiquafosol sodium is a purinergic P2Y<sub>2</sub> receptor agonist that is garnering much interest for its potential therapeutic benefits in ocular surface management. This review provides a comprehensive analysis of diquafosol’s pharmacology, clinical effectiveness, and role in the evolving landscape of ocular surface management. Future research should focus on optimising formulations, treatment duration, and exploring potential combination therapies to maximise therapeutic outcomes. By targeting underlying pathophysiological mechanisms, diquafosol represents a significant advancement in ocular surface management and a valuable addition to existing therapies.https://www.mdpi.com/2075-1729/15/3/484dry eyediquafosolocular surface disorderstear film-oriented therapytear film-oriented diagnosistopical non-steroidal immunosuppressants |
| spellingShingle | Chelsea Qiu Lin Tan Duoduo Wu Xin Yun Toh Blanche Xiaohong Lim Kendrick Co Shih Louis Tong Chris Hong Long Lim Applications of Diquafosol Sodium in Ophthalmology: A Comprehensive Review of Therapeutic Utility Life dry eye diquafosol ocular surface disorders tear film-oriented therapy tear film-oriented diagnosis topical non-steroidal immunosuppressants |
| title | Applications of Diquafosol Sodium in Ophthalmology: A Comprehensive Review of Therapeutic Utility |
| title_full | Applications of Diquafosol Sodium in Ophthalmology: A Comprehensive Review of Therapeutic Utility |
| title_fullStr | Applications of Diquafosol Sodium in Ophthalmology: A Comprehensive Review of Therapeutic Utility |
| title_full_unstemmed | Applications of Diquafosol Sodium in Ophthalmology: A Comprehensive Review of Therapeutic Utility |
| title_short | Applications of Diquafosol Sodium in Ophthalmology: A Comprehensive Review of Therapeutic Utility |
| title_sort | applications of diquafosol sodium in ophthalmology a comprehensive review of therapeutic utility |
| topic | dry eye diquafosol ocular surface disorders tear film-oriented therapy tear film-oriented diagnosis topical non-steroidal immunosuppressants |
| url | https://www.mdpi.com/2075-1729/15/3/484 |
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