Applications of Diquafosol Sodium in Ophthalmology: A Comprehensive Review of Therapeutic Utility

Diquafosol sodium is a purinergic P2Y<sub>2</sub> receptor agonist that is garnering much interest for its potential therapeutic benefits in ocular surface management. This review provides a comprehensive analysis of diquafosol’s pharmacology, clinical effectiveness, and role in the evol...

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Bibliographic Details
Main Authors: Chelsea Qiu Lin Tan, Duoduo Wu, Xin Yun Toh, Blanche Xiaohong Lim, Kendrick Co Shih, Louis Tong, Chris Hong Long Lim
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Life
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Online Access:https://www.mdpi.com/2075-1729/15/3/484
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Summary:Diquafosol sodium is a purinergic P2Y<sub>2</sub> receptor agonist that is garnering much interest for its potential therapeutic benefits in ocular surface management. This review provides a comprehensive analysis of diquafosol’s pharmacology, clinical effectiveness, and role in the evolving landscape of ocular surface management. Future research should focus on optimising formulations, treatment duration, and exploring potential combination therapies to maximise therapeutic outcomes. By targeting underlying pathophysiological mechanisms, diquafosol represents a significant advancement in ocular surface management and a valuable addition to existing therapies.
ISSN:2075-1729