Dematiaceous Fungal Infections in Kidney Transplant Recipients – Case Series
This retrospective, single-center study analyzed the clinical profile and outcomes of dematiaceous fungal infections in kidney transplant recipients over a 12-year period (2010–2022). Out of 1,041 transplant recipients, 69 developed major fungal infections, with dematiaceous fungi accounting for 8.6...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Indian Journal of Transplantation |
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| Online Access: | https://journals.lww.com/10.4103/ijot.ijot_112_24 |
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| author | Chilaka Rajesh Madhurima Ponmar Athul Thomas Jeethu Joseph Eapen Elenjickal Elias John Anna T. Valson Suceena Alexander Vinoi George David Joy Sarojini Michael Santosh Varughese |
| author_facet | Chilaka Rajesh Madhurima Ponmar Athul Thomas Jeethu Joseph Eapen Elenjickal Elias John Anna T. Valson Suceena Alexander Vinoi George David Joy Sarojini Michael Santosh Varughese |
| author_sort | Chilaka Rajesh |
| collection | DOAJ |
| description | This retrospective, single-center study analyzed the clinical profile and outcomes of dematiaceous fungal infections in kidney transplant recipients over a 12-year period (2010–2022). Out of 1,041 transplant recipients, 69 developed major fungal infections, with dematiaceous fungi accounting for 8.6% of cases (n=6). These infections affected predominantly middle-aged adults (mean age 47 ± 13.1 years), with a slight male predominance. Most patients received kidneys from live-related donors and were maintained on standard immunosuppressive regimens. Dematiaceous fungal infections manifested on average 3.43 ± 1.8 years post-transplant, presenting as skin lesions, arthritis, or sinusitis. Diagnosis was confirmed through culture and histopathology, revealing phaeohyphomycosis in most cases. Management included long-term oral itraconazole therapy with regular monitoring; only one patient experienced a recurrence after five years. The findings underscore the need for heightened clinical suspicion in transplant recipients presenting with atypical skin or joint lesions, and highlight the importance of early microbiological and histopathological assessment. Prompt antifungal therapy, often alongside surgical intervention, is essential to prevent disease progression. |
| format | Article |
| id | doaj-art-80bd85ae3b0b476b874f7b709cc5a224 |
| institution | Kabale University |
| issn | 2212-0017 2212-0025 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Transplantation |
| spelling | doaj-art-80bd85ae3b0b476b874f7b709cc5a2242025-08-20T03:31:26ZengWolters Kluwer Medknow PublicationsIndian Journal of Transplantation2212-00172212-00252025-04-0119227127510.4103/ijot.ijot_112_24Dematiaceous Fungal Infections in Kidney Transplant Recipients – Case SeriesChilaka RajeshMadhurima PonmarAthul ThomasJeethu Joseph EapenElenjickal Elias JohnAnna T. ValsonSuceena AlexanderVinoi George DavidJoy Sarojini MichaelSantosh VarugheseThis retrospective, single-center study analyzed the clinical profile and outcomes of dematiaceous fungal infections in kidney transplant recipients over a 12-year period (2010–2022). Out of 1,041 transplant recipients, 69 developed major fungal infections, with dematiaceous fungi accounting for 8.6% of cases (n=6). These infections affected predominantly middle-aged adults (mean age 47 ± 13.1 years), with a slight male predominance. Most patients received kidneys from live-related donors and were maintained on standard immunosuppressive regimens. Dematiaceous fungal infections manifested on average 3.43 ± 1.8 years post-transplant, presenting as skin lesions, arthritis, or sinusitis. Diagnosis was confirmed through culture and histopathology, revealing phaeohyphomycosis in most cases. Management included long-term oral itraconazole therapy with regular monitoring; only one patient experienced a recurrence after five years. The findings underscore the need for heightened clinical suspicion in transplant recipients presenting with atypical skin or joint lesions, and highlight the importance of early microbiological and histopathological assessment. Prompt antifungal therapy, often alongside surgical intervention, is essential to prevent disease progression.https://journals.lww.com/10.4103/ijot.ijot_112_24dematiaceous fungiitraconazolekidney transplant recipientsphaeohyphomycosis |
| spellingShingle | Chilaka Rajesh Madhurima Ponmar Athul Thomas Jeethu Joseph Eapen Elenjickal Elias John Anna T. Valson Suceena Alexander Vinoi George David Joy Sarojini Michael Santosh Varughese Dematiaceous Fungal Infections in Kidney Transplant Recipients – Case Series Indian Journal of Transplantation dematiaceous fungi itraconazole kidney transplant recipients phaeohyphomycosis |
| title | Dematiaceous Fungal Infections in Kidney Transplant Recipients – Case Series |
| title_full | Dematiaceous Fungal Infections in Kidney Transplant Recipients – Case Series |
| title_fullStr | Dematiaceous Fungal Infections in Kidney Transplant Recipients – Case Series |
| title_full_unstemmed | Dematiaceous Fungal Infections in Kidney Transplant Recipients – Case Series |
| title_short | Dematiaceous Fungal Infections in Kidney Transplant Recipients – Case Series |
| title_sort | dematiaceous fungal infections in kidney transplant recipients case series |
| topic | dematiaceous fungi itraconazole kidney transplant recipients phaeohyphomycosis |
| url | https://journals.lww.com/10.4103/ijot.ijot_112_24 |
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