Mesenchymal Stem Cell Therapy Modulates the Inflammatory Response in Experimental Traumatic Brain Injury
Therapy with mesenchymal stem cells (MSCs) has showed to be promising due to its immunomodulatory function. Traumatic brain injury (TBI) triggers immune response and release of inflammatory mediators, mainly cytokines, by glial cells creating a hostile microenvironment for endogenous neural stem cel...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2011/564089 |
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| author | Layla T. Galindo Thais R. M. Filippo Patricia Semedo Carolina B. Ariza Caroline M. Moreira Niels O. S. Camara Marimelia A. Porcionatto |
| author_facet | Layla T. Galindo Thais R. M. Filippo Patricia Semedo Carolina B. Ariza Caroline M. Moreira Niels O. S. Camara Marimelia A. Porcionatto |
| author_sort | Layla T. Galindo |
| collection | DOAJ |
| description | Therapy with mesenchymal stem cells (MSCs) has showed to be promising due to its immunomodulatory function. Traumatic brain injury (TBI) triggers immune response and release of inflammatory mediators, mainly cytokines, by glial cells creating a hostile microenvironment for endogenous neural stem cells (NSCs). We investigated the effects of factors secreted by MSCs on NSC in vitro and analyzed cytokines expression in vitro in a TBI model. Our in vitro results show that MSC-secreted factors increase NSC proliferation and induce higher expression of GFAP, indicating a tendency toward differentiation into astrocytes. In vivo experiments showed that MSC injection at an acute model of brain injury diminishes a broad profile of cytokines in the tissue, suggesting that MSC-secreted factors may modulate the inflammation at the injury site, which may be of interest to the development of a favorable microenvironment for endogenous NSC and consequently to repair the injured tissue. |
| format | Article |
| id | doaj-art-80bd2bd3dcad4253a91d74978c85f71c |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-80bd2bd3dcad4253a91d74978c85f71c2025-08-20T03:35:15ZengWileyNeurology Research International2090-18522090-18602011-01-01201110.1155/2011/564089564089Mesenchymal Stem Cell Therapy Modulates the Inflammatory Response in Experimental Traumatic Brain InjuryLayla T. Galindo0Thais R. M. Filippo1Patricia Semedo2Carolina B. Ariza3Caroline M. Moreira4Niels O. S. Camara5Marimelia A. Porcionatto6Departamento de Bioquímica, Universidade Federal de São Paulo, Rua Três de Maio 100, 04044-020 São Paulo, SP, BrazilDepartamento de Bioquímica, Universidade Federal de São Paulo, Rua Três de Maio 100, 04044-020 São Paulo, SP, BrazilDepartamento de Imunologia, Universidade de São Paulo, 05508-000 São Paulo, SP, BrazilDepartamento de Bioquímica, Universidade Federal de São Paulo, Rua Três de Maio 100, 04044-020 São Paulo, SP, BrazilDepartamento de Bioquímica, Universidade Federal de São Paulo, Rua Três de Maio 100, 04044-020 São Paulo, SP, BrazilDepartamento de Imunologia, Universidade de São Paulo, 05508-000 São Paulo, SP, BrazilDepartamento de Bioquímica, Universidade Federal de São Paulo, Rua Três de Maio 100, 04044-020 São Paulo, SP, BrazilTherapy with mesenchymal stem cells (MSCs) has showed to be promising due to its immunomodulatory function. Traumatic brain injury (TBI) triggers immune response and release of inflammatory mediators, mainly cytokines, by glial cells creating a hostile microenvironment for endogenous neural stem cells (NSCs). We investigated the effects of factors secreted by MSCs on NSC in vitro and analyzed cytokines expression in vitro in a TBI model. Our in vitro results show that MSC-secreted factors increase NSC proliferation and induce higher expression of GFAP, indicating a tendency toward differentiation into astrocytes. In vivo experiments showed that MSC injection at an acute model of brain injury diminishes a broad profile of cytokines in the tissue, suggesting that MSC-secreted factors may modulate the inflammation at the injury site, which may be of interest to the development of a favorable microenvironment for endogenous NSC and consequently to repair the injured tissue.http://dx.doi.org/10.1155/2011/564089 |
| spellingShingle | Layla T. Galindo Thais R. M. Filippo Patricia Semedo Carolina B. Ariza Caroline M. Moreira Niels O. S. Camara Marimelia A. Porcionatto Mesenchymal Stem Cell Therapy Modulates the Inflammatory Response in Experimental Traumatic Brain Injury Neurology Research International |
| title | Mesenchymal Stem Cell Therapy Modulates the Inflammatory Response in Experimental Traumatic Brain Injury |
| title_full | Mesenchymal Stem Cell Therapy Modulates the Inflammatory Response in Experimental Traumatic Brain Injury |
| title_fullStr | Mesenchymal Stem Cell Therapy Modulates the Inflammatory Response in Experimental Traumatic Brain Injury |
| title_full_unstemmed | Mesenchymal Stem Cell Therapy Modulates the Inflammatory Response in Experimental Traumatic Brain Injury |
| title_short | Mesenchymal Stem Cell Therapy Modulates the Inflammatory Response in Experimental Traumatic Brain Injury |
| title_sort | mesenchymal stem cell therapy modulates the inflammatory response in experimental traumatic brain injury |
| url | http://dx.doi.org/10.1155/2011/564089 |
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