Multisite binding of bacteriophages on lipopolysaccharides in Escherichia coli O157:H7 and the adaptive costs of phage resistance

Multisite binding of bacteriophages on lipopolysaccharides in Escherichia coli O157:H7 and the adaptive costs of phage resistance

ABSTRACT Escherichia coli (E. coli) O157:H7 is a major foodborne pathogen and a critical global food safety concern. Bacteriophage (phage) therapy offers a promising, highly specific biological alternative to antibiotic treatment. However, the clinical application of phage therapy is frequently limi...

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Bibliographic Details
Main Authors: Yang Wang, Jing Li, Yuhan Zhang, Yao Li, Xinru Chen, Jiaqi Cui, Feng Xue, Jianluan Ren, Jianjun Dai, Fang Tang
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:Microbiology Spectrum
Subjects:
E. coli O157:H7
phage
receptor
phage resistance
adaptive cost
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00067-25
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