Effect of Presence of Uni- or Bilateral Thyroid Adenoma on Recovery of Pituitary–Thyroid Axis and Creatinine Concentration in Radioiodine-Treated Cats
Radioiodine therapy (RAIT) is the gold standard for treatment of hyperthyroidism in cats. The aim of this study was to evaluate the effect of the presence of uni- or bilateral thyroid adenoma on changes in total thyroxine (TT4), thyroid-stimulating hormone (TSH), and creatinine concentration over a...
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2024-09-01
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| author | Anna Paulina Menzel Joanna Lin Arne Güssow Ve Patzelt Natali Bauer Katarina Hazuchova |
| author_facet | Anna Paulina Menzel Joanna Lin Arne Güssow Ve Patzelt Natali Bauer Katarina Hazuchova |
| author_sort | Anna Paulina Menzel |
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| description | Radioiodine therapy (RAIT) is the gold standard for treatment of hyperthyroidism in cats. The aim of this study was to evaluate the effect of the presence of uni- or bilateral thyroid adenoma on changes in total thyroxine (TT4), thyroid-stimulating hormone (TSH), and creatinine concentration over a period of 6 to 12 months following RAIT. Fifty-one hyperthyroid cats presented for RAIT between April 2021 and April 2022 were prospectively enrolled. Cats with an increased creatinine concentration (creatinine ≥ 140 µmol/L), renal morphology abnormalities, and suspected thyroid carcinoma were excluded. TT4, TSH, and creatinine were determined before and one week and one, three, six, and twelve months following RAIT. The effects of the re-examination timepoint following RAIT and the presence of uni- or bilateral thyroid adenoma based on technetium-99m scintigraphy on TT4, TSH, and creatinine were analysed by mixed effects modelling. Cats with bilateral adenoma had significantly higher TSH concentrations after RAIT compared to those with unilateral adenoma. TT4 concentration significantly decreased one week (<i>p</i> < 0.001) and again one month following RAIT (<i>p</i> < 0.001). TSH and creatinine concentration significantly increased one month post RAIT (both <i>p</i> < 0.001). As indicated by an increase in TSH concentration, the pituitary–thyroid axis needs a minimum of one month post RAIT to recover from hyperthyroidism-induced suppression, but hypothyroidism necessitating levothyroxine supplementation might not be diagnosed before 6 or even 12 months post RAIT. Although creatinine did not increase significantly after one month post RAIT in this cohort, an increased creatinine concentration was detected at later timepoints in individual cats. |
| format | Article |
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| publishDate | 2024-09-01 |
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| spelling | doaj-art-80b40a3446754864b9c6981477cd70c02025-08-20T01:56:04ZengMDPI AGAnimals2076-26152024-09-011418262710.3390/ani14182627Effect of Presence of Uni- or Bilateral Thyroid Adenoma on Recovery of Pituitary–Thyroid Axis and Creatinine Concentration in Radioiodine-Treated CatsAnna Paulina Menzel0Joanna Lin1Arne Güssow2Ve Patzelt3Natali Bauer4Katarina Hazuchova5Clinic for Small Animals (Internal Medicine, Clinical Pathology and Clinical Pathophysiology), Justus-Liebig University of Giessen, 35392 Giessen, GermanyClinic for Small Animals (Internal Medicine, Clinical Pathology and Clinical Pathophysiology), Justus-Liebig University of Giessen, 35392 Giessen, GermanyClinic for Small Animals (Internal Medicine, Clinical Pathology and Clinical Pathophysiology), Justus-Liebig University of Giessen, 35392 Giessen, GermanyClinic for Small Animals (Internal Medicine, Clinical Pathology and Clinical Pathophysiology), Justus-Liebig University of Giessen, 35392 Giessen, GermanyClinic for Small Animals (Internal Medicine, Clinical Pathology and Clinical Pathophysiology), Justus-Liebig University of Giessen, 35392 Giessen, GermanyClinic for Small Animals (Internal Medicine, Clinical Pathology and Clinical Pathophysiology), Justus-Liebig University of Giessen, 35392 Giessen, GermanyRadioiodine therapy (RAIT) is the gold standard for treatment of hyperthyroidism in cats. The aim of this study was to evaluate the effect of the presence of uni- or bilateral thyroid adenoma on changes in total thyroxine (TT4), thyroid-stimulating hormone (TSH), and creatinine concentration over a period of 6 to 12 months following RAIT. Fifty-one hyperthyroid cats presented for RAIT between April 2021 and April 2022 were prospectively enrolled. Cats with an increased creatinine concentration (creatinine ≥ 140 µmol/L), renal morphology abnormalities, and suspected thyroid carcinoma were excluded. TT4, TSH, and creatinine were determined before and one week and one, three, six, and twelve months following RAIT. The effects of the re-examination timepoint following RAIT and the presence of uni- or bilateral thyroid adenoma based on technetium-99m scintigraphy on TT4, TSH, and creatinine were analysed by mixed effects modelling. Cats with bilateral adenoma had significantly higher TSH concentrations after RAIT compared to those with unilateral adenoma. TT4 concentration significantly decreased one week (<i>p</i> < 0.001) and again one month following RAIT (<i>p</i> < 0.001). TSH and creatinine concentration significantly increased one month post RAIT (both <i>p</i> < 0.001). As indicated by an increase in TSH concentration, the pituitary–thyroid axis needs a minimum of one month post RAIT to recover from hyperthyroidism-induced suppression, but hypothyroidism necessitating levothyroxine supplementation might not be diagnosed before 6 or even 12 months post RAIT. Although creatinine did not increase significantly after one month post RAIT in this cohort, an increased creatinine concentration was detected at later timepoints in individual cats.https://www.mdpi.com/2076-2615/14/18/2627thyroxinethyroid-stimulating hormoneiatrogenic hypothyroidismazotaemiachronic kidney diseaseradioiodine treatment |
| spellingShingle | Anna Paulina Menzel Joanna Lin Arne Güssow Ve Patzelt Natali Bauer Katarina Hazuchova Effect of Presence of Uni- or Bilateral Thyroid Adenoma on Recovery of Pituitary–Thyroid Axis and Creatinine Concentration in Radioiodine-Treated Cats Animals thyroxine thyroid-stimulating hormone iatrogenic hypothyroidism azotaemia chronic kidney disease radioiodine treatment |
| title | Effect of Presence of Uni- or Bilateral Thyroid Adenoma on Recovery of Pituitary–Thyroid Axis and Creatinine Concentration in Radioiodine-Treated Cats |
| title_full | Effect of Presence of Uni- or Bilateral Thyroid Adenoma on Recovery of Pituitary–Thyroid Axis and Creatinine Concentration in Radioiodine-Treated Cats |
| title_fullStr | Effect of Presence of Uni- or Bilateral Thyroid Adenoma on Recovery of Pituitary–Thyroid Axis and Creatinine Concentration in Radioiodine-Treated Cats |
| title_full_unstemmed | Effect of Presence of Uni- or Bilateral Thyroid Adenoma on Recovery of Pituitary–Thyroid Axis and Creatinine Concentration in Radioiodine-Treated Cats |
| title_short | Effect of Presence of Uni- or Bilateral Thyroid Adenoma on Recovery of Pituitary–Thyroid Axis and Creatinine Concentration in Radioiodine-Treated Cats |
| title_sort | effect of presence of uni or bilateral thyroid adenoma on recovery of pituitary thyroid axis and creatinine concentration in radioiodine treated cats |
| topic | thyroxine thyroid-stimulating hormone iatrogenic hypothyroidism azotaemia chronic kidney disease radioiodine treatment |
| url | https://www.mdpi.com/2076-2615/14/18/2627 |
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