A Case of Rapidly Progressing Hepatocellular Carcinoma after Administration of JAK Inhibitors to Treat Rheumatoid Arthritis
We report a case of rapidly progressing hepatocellular carcinoma after administration of Janus kinase (JAK) inhibitors to treat rheumatoid arthritis. A 76-year-old man was referred to our Department for pain in multiple joints and was diagnosed with rheumatoid arthritis. Blood tests revealed elevate...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2022/6852189 |
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| _version_ | 1850214592755531776 |
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| author | Rioko Migita Yasutaka Kimoto Junki Hiura Yuta Okumura Takahiko Horiuchi |
| author_facet | Rioko Migita Yasutaka Kimoto Junki Hiura Yuta Okumura Takahiko Horiuchi |
| author_sort | Rioko Migita |
| collection | DOAJ |
| description | We report a case of rapidly progressing hepatocellular carcinoma after administration of Janus kinase (JAK) inhibitors to treat rheumatoid arthritis. A 76-year-old man was referred to our Department for pain in multiple joints and was diagnosed with rheumatoid arthritis. Blood tests revealed elevated hepatobiliary enzymes, but various tests revealed no signs suggestive of malignancy. He took baricitinib for 2 months followed by tofacitinib for 4 months. After that, he was diagnosed with hepatocellular carcinoma based on imaging findings and elevated tumor markers. This case showed the possibility of a causal relationship between JAK inhibitors and malignancy. |
| format | Article |
| id | doaj-art-80b20d8df551418ba13799da3ff2de41 |
| institution | OA Journals |
| issn | 2090-6897 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-80b20d8df551418ba13799da3ff2de412025-08-20T02:08:50ZengWileyCase Reports in Rheumatology2090-68972022-01-01202210.1155/2022/6852189A Case of Rapidly Progressing Hepatocellular Carcinoma after Administration of JAK Inhibitors to Treat Rheumatoid ArthritisRioko Migita0Yasutaka Kimoto1Junki Hiura2Yuta Okumura3Takahiko Horiuchi4Kyushu University Beppu HospitalKyushu University Beppu HospitalKyushu University Beppu HospitalKyushu University Beppu HospitalKyushu University Beppu HospitalWe report a case of rapidly progressing hepatocellular carcinoma after administration of Janus kinase (JAK) inhibitors to treat rheumatoid arthritis. A 76-year-old man was referred to our Department for pain in multiple joints and was diagnosed with rheumatoid arthritis. Blood tests revealed elevated hepatobiliary enzymes, but various tests revealed no signs suggestive of malignancy. He took baricitinib for 2 months followed by tofacitinib for 4 months. After that, he was diagnosed with hepatocellular carcinoma based on imaging findings and elevated tumor markers. This case showed the possibility of a causal relationship between JAK inhibitors and malignancy.http://dx.doi.org/10.1155/2022/6852189 |
| spellingShingle | Rioko Migita Yasutaka Kimoto Junki Hiura Yuta Okumura Takahiko Horiuchi A Case of Rapidly Progressing Hepatocellular Carcinoma after Administration of JAK Inhibitors to Treat Rheumatoid Arthritis Case Reports in Rheumatology |
| title | A Case of Rapidly Progressing Hepatocellular Carcinoma after Administration of JAK Inhibitors to Treat Rheumatoid Arthritis |
| title_full | A Case of Rapidly Progressing Hepatocellular Carcinoma after Administration of JAK Inhibitors to Treat Rheumatoid Arthritis |
| title_fullStr | A Case of Rapidly Progressing Hepatocellular Carcinoma after Administration of JAK Inhibitors to Treat Rheumatoid Arthritis |
| title_full_unstemmed | A Case of Rapidly Progressing Hepatocellular Carcinoma after Administration of JAK Inhibitors to Treat Rheumatoid Arthritis |
| title_short | A Case of Rapidly Progressing Hepatocellular Carcinoma after Administration of JAK Inhibitors to Treat Rheumatoid Arthritis |
| title_sort | case of rapidly progressing hepatocellular carcinoma after administration of jak inhibitors to treat rheumatoid arthritis |
| url | http://dx.doi.org/10.1155/2022/6852189 |
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