Phytochemical Analysis and Antioxidant Activity Assessment of Croton linearifolius Stem Extracts

Croton linearifolius is a species with promising medicinal potential. This study investigated the antioxidant activity, total phenolic and flavonoid contents, and conducted chemical prospecting of its ethanolic stem extract and fractions. The extract was obtained by exhaustive percolation with 70%...

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Main Authors: Cleia Teixeira Santos de Franca, Marcel Mark da Silva Passos, Matheus Andrade Rocha Costa, Esaul Lucas Oliveira, Simone Andrade Gualberto
Format: Article
Language:English
Published: Universidade Estadual de Londrina 2025-04-01
Series:Semina: Ciências Exatas e Tecnológicas
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Online Access:https://www.ojs.uel.br/revistas/uel/index.php/semexatas/article/view/50875
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author Cleia Teixeira Santos de Franca
Marcel Mark da Silva Passos
Matheus Andrade Rocha Costa
Esaul Lucas Oliveira
Simone Andrade Gualberto
author_facet Cleia Teixeira Santos de Franca
Marcel Mark da Silva Passos
Matheus Andrade Rocha Costa
Esaul Lucas Oliveira
Simone Andrade Gualberto
author_sort Cleia Teixeira Santos de Franca
collection DOAJ
description Croton linearifolius is a species with promising medicinal potential. This study investigated the antioxidant activity, total phenolic and flavonoid contents, and conducted chemical prospecting of its ethanolic stem extract and fractions. The extract was obtained by exhaustive percolation with 70% hydroethanolic solution, followed by liquid-liquid partitioning using hexane, dichloromethane, and ethyl acetate. In vitro tests were used for chemical analysis, and antioxidant activity was evaluated by DPPH and FRAP methods. The ethyl acetate fraction showed the highest antioxidant activity (80.62% in DPPH), with elevated phenolic and flavonoid levels, indicating potential for herbal medicine development.
format Article
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issn 1676-5451
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language English
publishDate 2025-04-01
publisher Universidade Estadual de Londrina
record_format Article
series Semina: Ciências Exatas e Tecnológicas
spelling doaj-art-80af4d3789d141d4b40c57d6462ce73c2025-08-20T03:05:21ZengUniversidade Estadual de LondrinaSemina: Ciências Exatas e Tecnológicas1676-54511679-03752025-04-014610.5433/1679-0375.2025.v46.50875Phytochemical Analysis and Antioxidant Activity Assessment of Croton linearifolius Stem ExtractsCleia Teixeira Santos de Franca0https://orcid.org/0000-0002-5566-1469Marcel Mark da Silva Passos1https://orcid.org/0000-0002-2832-9882Matheus Andrade Rocha Costa2https://orcid.org/0000-0003-0194-3310Esaul Lucas Oliveira3https://orcid.org/0009-0008-8594-7637Simone Andrade Gualberto4https://orcid.org/0000-0002-1753-002XSouthwest Bahia State UniversityUniversidade Federal de CatalãoUniversidade Federal de PernambucoSouthwest Bahia State UniversitySouthwest Bahia State University Croton linearifolius is a species with promising medicinal potential. This study investigated the antioxidant activity, total phenolic and flavonoid contents, and conducted chemical prospecting of its ethanolic stem extract and fractions. The extract was obtained by exhaustive percolation with 70% hydroethanolic solution, followed by liquid-liquid partitioning using hexane, dichloromethane, and ethyl acetate. In vitro tests were used for chemical analysis, and antioxidant activity was evaluated by DPPH and FRAP methods. The ethyl acetate fraction showed the highest antioxidant activity (80.62% in DPPH), with elevated phenolic and flavonoid levels, indicating potential for herbal medicine development. https://www.ojs.uel.br/revistas/uel/index.php/semexatas/article/view/50875Croton linearifoliusantioxidant activityphenolic compoundsflavonoids
spellingShingle Cleia Teixeira Santos de Franca
Marcel Mark da Silva Passos
Matheus Andrade Rocha Costa
Esaul Lucas Oliveira
Simone Andrade Gualberto
Phytochemical Analysis and Antioxidant Activity Assessment of Croton linearifolius Stem Extracts
Semina: Ciências Exatas e Tecnológicas
Croton linearifolius
antioxidant activity
phenolic compounds
flavonoids
title Phytochemical Analysis and Antioxidant Activity Assessment of Croton linearifolius Stem Extracts
title_full Phytochemical Analysis and Antioxidant Activity Assessment of Croton linearifolius Stem Extracts
title_fullStr Phytochemical Analysis and Antioxidant Activity Assessment of Croton linearifolius Stem Extracts
title_full_unstemmed Phytochemical Analysis and Antioxidant Activity Assessment of Croton linearifolius Stem Extracts
title_short Phytochemical Analysis and Antioxidant Activity Assessment of Croton linearifolius Stem Extracts
title_sort phytochemical analysis and antioxidant activity assessment of croton linearifolius stem extracts
topic Croton linearifolius
antioxidant activity
phenolic compounds
flavonoids
url https://www.ojs.uel.br/revistas/uel/index.php/semexatas/article/view/50875
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AT matheusandraderochacosta phytochemicalanalysisandantioxidantactivityassessmentofcrotonlinearifoliusstemextracts
AT esaullucasoliveira phytochemicalanalysisandantioxidantactivityassessmentofcrotonlinearifoliusstemextracts
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