Long-Term Prognostic Power of Three-Dimensional Speckle-Tracking Echocardiography-Derived Peak Left Atrial Reservoir Global Longitudinal Strain in Healthy Adults—An Analysis from the MAGYAR-Healthy Study
<b>Introduction:</b> The contraction–relaxation pattern of the left atrial (LA) walls is opposite to that detected in the left ventricle, which includes thinning in radial, lengthening in longitudinal, and widening in circumferential directions in the systolic reservoir phase of LA funct...
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2025-02-01
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| author | Attila Nemes Dorottya Lilla Olajos Alexandru Achim Zoltán Ruzsa Nóra Ambrus Csaba Lengyel |
| author_facet | Attila Nemes Dorottya Lilla Olajos Alexandru Achim Zoltán Ruzsa Nóra Ambrus Csaba Lengyel |
| author_sort | Attila Nemes |
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| description | <b>Introduction:</b> The contraction–relaxation pattern of the left atrial (LA) walls is opposite to that detected in the left ventricle, which includes thinning in radial, lengthening in longitudinal, and widening in circumferential directions in the systolic reservoir phase of LA function as measured by three-dimensional speckle-tracking echocardiography (3DSTE). Global longitudinal strain (GLS) is a quantitative feature of longitudinal wall contraction referring to the whole LA. The present study aims to clarify the expected prognostic impact of peak LA-GLS as assessed by 3DSTE in healthy participants during a long-term follow-up period. <b>Methods:</b> The study consisted of 142 healthy adults (with an average age of 32.1 ± 12.7 years; 72 of the participants were men), in whom complete two-dimensional Doppler echocardiography and 3DSTE were performed on a voluntary basis. <b>Results:</b> Thirteen adults suffered from a cardiovascular event, including two cardiac deaths during a mean follow-up of 8.35 ± 4.20 years. Peak LA-GLS ≥ 20.9%, as assessed by 3DSTE, was found to be a significant predictor for cardiovascular event-free survival by using ROC analysis (specificity 74%, sensitivity 62%, area under the curve 0.69, <i>p</i> = 0.025). Healthy individuals with peak LA-GLS < 20.9% had a lower LV-EF and a significantly higher ratio of cardiovascular events compared to cases with peak LA-GLS ≥ 20.9%. Subjects who experienced cardiovascular events had lower peak LA-GLS and the ratio of subjects with peak LA-GLS < 20.9% proved to be significantly increased compared to that of cases without cardiovascular events. <b>Conclusions:</b> 3DSTE-derived peak LA-GLS representing LA lengthening in the end-systolic reservoir phase of LA function predicts future cardiovascular events in healthy adults. |
| format | Article |
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| institution | DOAJ |
| issn | 2075-1729 |
| language | English |
| publishDate | 2025-02-01 |
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| series | Life |
| spelling | doaj-art-80ae79f1f90d422983648d326bb7cd882025-08-20T02:44:32ZengMDPI AGLife2075-17292025-02-0115223210.3390/life15020232Long-Term Prognostic Power of Three-Dimensional Speckle-Tracking Echocardiography-Derived Peak Left Atrial Reservoir Global Longitudinal Strain in Healthy Adults—An Analysis from the MAGYAR-Healthy StudyAttila Nemes0Dorottya Lilla Olajos1Alexandru Achim2Zoltán Ruzsa3Nóra Ambrus4Csaba Lengyel5Department of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, H-6725 Szeged, HungaryDepartment of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, H-6725 Szeged, HungaryDepartment of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, H-6725 Szeged, HungaryDepartment of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, H-6725 Szeged, HungaryDepartment of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, H-6725 Szeged, HungaryDepartment of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, H-6725 Szeged, Hungary<b>Introduction:</b> The contraction–relaxation pattern of the left atrial (LA) walls is opposite to that detected in the left ventricle, which includes thinning in radial, lengthening in longitudinal, and widening in circumferential directions in the systolic reservoir phase of LA function as measured by three-dimensional speckle-tracking echocardiography (3DSTE). Global longitudinal strain (GLS) is a quantitative feature of longitudinal wall contraction referring to the whole LA. The present study aims to clarify the expected prognostic impact of peak LA-GLS as assessed by 3DSTE in healthy participants during a long-term follow-up period. <b>Methods:</b> The study consisted of 142 healthy adults (with an average age of 32.1 ± 12.7 years; 72 of the participants were men), in whom complete two-dimensional Doppler echocardiography and 3DSTE were performed on a voluntary basis. <b>Results:</b> Thirteen adults suffered from a cardiovascular event, including two cardiac deaths during a mean follow-up of 8.35 ± 4.20 years. Peak LA-GLS ≥ 20.9%, as assessed by 3DSTE, was found to be a significant predictor for cardiovascular event-free survival by using ROC analysis (specificity 74%, sensitivity 62%, area under the curve 0.69, <i>p</i> = 0.025). Healthy individuals with peak LA-GLS < 20.9% had a lower LV-EF and a significantly higher ratio of cardiovascular events compared to cases with peak LA-GLS ≥ 20.9%. Subjects who experienced cardiovascular events had lower peak LA-GLS and the ratio of subjects with peak LA-GLS < 20.9% proved to be significantly increased compared to that of cases without cardiovascular events. <b>Conclusions:</b> 3DSTE-derived peak LA-GLS representing LA lengthening in the end-systolic reservoir phase of LA function predicts future cardiovascular events in healthy adults.https://www.mdpi.com/2075-1729/15/2/232left atrialreservoirstrainprognosisthree-dimensionalspeckle-tracking |
| spellingShingle | Attila Nemes Dorottya Lilla Olajos Alexandru Achim Zoltán Ruzsa Nóra Ambrus Csaba Lengyel Long-Term Prognostic Power of Three-Dimensional Speckle-Tracking Echocardiography-Derived Peak Left Atrial Reservoir Global Longitudinal Strain in Healthy Adults—An Analysis from the MAGYAR-Healthy Study Life left atrial reservoir strain prognosis three-dimensional speckle-tracking |
| title | Long-Term Prognostic Power of Three-Dimensional Speckle-Tracking Echocardiography-Derived Peak Left Atrial Reservoir Global Longitudinal Strain in Healthy Adults—An Analysis from the MAGYAR-Healthy Study |
| title_full | Long-Term Prognostic Power of Three-Dimensional Speckle-Tracking Echocardiography-Derived Peak Left Atrial Reservoir Global Longitudinal Strain in Healthy Adults—An Analysis from the MAGYAR-Healthy Study |
| title_fullStr | Long-Term Prognostic Power of Three-Dimensional Speckle-Tracking Echocardiography-Derived Peak Left Atrial Reservoir Global Longitudinal Strain in Healthy Adults—An Analysis from the MAGYAR-Healthy Study |
| title_full_unstemmed | Long-Term Prognostic Power of Three-Dimensional Speckle-Tracking Echocardiography-Derived Peak Left Atrial Reservoir Global Longitudinal Strain in Healthy Adults—An Analysis from the MAGYAR-Healthy Study |
| title_short | Long-Term Prognostic Power of Three-Dimensional Speckle-Tracking Echocardiography-Derived Peak Left Atrial Reservoir Global Longitudinal Strain in Healthy Adults—An Analysis from the MAGYAR-Healthy Study |
| title_sort | long term prognostic power of three dimensional speckle tracking echocardiography derived peak left atrial reservoir global longitudinal strain in healthy adults an analysis from the magyar healthy study |
| topic | left atrial reservoir strain prognosis three-dimensional speckle-tracking |
| url | https://www.mdpi.com/2075-1729/15/2/232 |
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