The Role of Viruses in Cellular Transformation and Cancer
ABSTRACT Background Viral infections are established contributors to oncogenesis, leading to significant public health challenges. This systematic review aims to synthesize current knowledge on the mechanisms of viral cellular transformation and their association with various cancers. Recent finding...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-02-01
|
| Series: | Cancer Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cnr2.70150 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849765336577998848 |
|---|---|
| author | Donath Damian |
| author_facet | Donath Damian |
| author_sort | Donath Damian |
| collection | DOAJ |
| description | ABSTRACT Background Viral infections are established contributors to oncogenesis, leading to significant public health challenges. This systematic review aims to synthesize current knowledge on the mechanisms of viral cellular transformation and their association with various cancers. Recent findings Studies reveal key mechanisms of oncogenesis, including direct viral integration into the host genome, expression of viral oncogenes, and indirect pathways such as chronic inflammation and immune evasion. Notably, Human Papillomavirus (HPV) was linked predominantly to cervical and oropharyngeal cancers, while Epstein–Barr Virus (EBV) was associated with lymphomas. Hepatitis B and C viruses were linked to liver cancer, highlighting the diverse impacts of viral infections on oncogenic processes. Conclusions This review underscores the complexity of viral interactions with host cells and their implications for cancer development. Findings suggest that targeted interventions, such as vaccination and antiviral therapies, may play a crucial role in reducing the incidence of virus‐related cancers. Further research is needed to explore novel therapeutic strategies and the role of co‐factors in viral oncogenesis. |
| format | Article |
| id | doaj-art-80ab2a62b03d4e5f8ca2d98320499bb4 |
| institution | DOAJ |
| issn | 2573-8348 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj-art-80ab2a62b03d4e5f8ca2d98320499bb42025-08-20T03:04:53ZengWileyCancer Reports2573-83482025-02-0182n/an/a10.1002/cnr2.70150The Role of Viruses in Cellular Transformation and CancerDonath Damian0Department of Biochemistry University of Dar es Salaam – Mbeya College of Health and Allied Sciences Mbeya TanzaniaABSTRACT Background Viral infections are established contributors to oncogenesis, leading to significant public health challenges. This systematic review aims to synthesize current knowledge on the mechanisms of viral cellular transformation and their association with various cancers. Recent findings Studies reveal key mechanisms of oncogenesis, including direct viral integration into the host genome, expression of viral oncogenes, and indirect pathways such as chronic inflammation and immune evasion. Notably, Human Papillomavirus (HPV) was linked predominantly to cervical and oropharyngeal cancers, while Epstein–Barr Virus (EBV) was associated with lymphomas. Hepatitis B and C viruses were linked to liver cancer, highlighting the diverse impacts of viral infections on oncogenic processes. Conclusions This review underscores the complexity of viral interactions with host cells and their implications for cancer development. Findings suggest that targeted interventions, such as vaccination and antiviral therapies, may play a crucial role in reducing the incidence of virus‐related cancers. Further research is needed to explore novel therapeutic strategies and the role of co‐factors in viral oncogenesis.https://doi.org/10.1002/cnr2.70150cancer mechanismscellular transformationEBVHPVsystematic reviewviral oncogenesis |
| spellingShingle | Donath Damian The Role of Viruses in Cellular Transformation and Cancer Cancer Reports cancer mechanisms cellular transformation EBV HPV systematic review viral oncogenesis |
| title | The Role of Viruses in Cellular Transformation and Cancer |
| title_full | The Role of Viruses in Cellular Transformation and Cancer |
| title_fullStr | The Role of Viruses in Cellular Transformation and Cancer |
| title_full_unstemmed | The Role of Viruses in Cellular Transformation and Cancer |
| title_short | The Role of Viruses in Cellular Transformation and Cancer |
| title_sort | role of viruses in cellular transformation and cancer |
| topic | cancer mechanisms cellular transformation EBV HPV systematic review viral oncogenesis |
| url | https://doi.org/10.1002/cnr2.70150 |
| work_keys_str_mv | AT donathdamian theroleofvirusesincellulartransformationandcancer AT donathdamian roleofvirusesincellulartransformationandcancer |