Rationale for the Use of Cord Blood in Hypoxic-Ischaemic Encephalopathy
Hypoxic-ischaemic encephalopathy (HIE) is a severe complication of asphyxia at birth. Therapeutic hypothermia, the standard method for HIE prevention, is effective in only 50% of the cases. As the understanding of the immunological basis of these changes increases, experiments have begun with the us...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2022/9125460 |
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| author | Izabela Zdolińska-Malinowska Dariusz Boruczkowski Dominika Hołowaty Paweł Krajewski Emilian Snarski |
| author_facet | Izabela Zdolińska-Malinowska Dariusz Boruczkowski Dominika Hołowaty Paweł Krajewski Emilian Snarski |
| author_sort | Izabela Zdolińska-Malinowska |
| collection | DOAJ |
| description | Hypoxic-ischaemic encephalopathy (HIE) is a severe complication of asphyxia at birth. Therapeutic hypothermia, the standard method for HIE prevention, is effective in only 50% of the cases. As the understanding of the immunological basis of these changes increases, experiments have begun with the use of cord blood (CB) because of its neuroprotective properties. Mechanisms for the neuroprotective effects of CB stem cells include antiapoptotic and anti-inflammatory actions, stimulation of angiogenesis, production of trophic factors, and mitochondrial donation. In several animal models of HIE, CB decreased oxidative stress, cell death markers, CD4+ T cell infiltration, and microglial activation; restored normal brain metabolic activity; promoted neurogenesis; improved myelination; and increased the proportion of mature oligodendrocytes, neuron numbers in the motor cortex and somatosensory cortex, and brain weight. These observations translate into motor strength, limb function, gait, and cognitive function and behaviour. In humans, the efficacy and safety of CB administration were reported in a few early clinical studies which confirmed the feasibility and safety of this intervention for up to 10 years. The results of these studies showed an improvement in the developmental outcomes over hypothermia. Two phase-2 clinical studies are ongoing under the United States regulations, namely one controlled study and one blinded study. |
| format | Article |
| id | doaj-art-80a93f8383064170a863a9bdc3812a03 |
| institution | Kabale University |
| issn | 1687-9678 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-80a93f8383064170a863a9bdc3812a032025-02-03T05:53:30ZengWileyStem Cells International1687-96782022-01-01202210.1155/2022/9125460Rationale for the Use of Cord Blood in Hypoxic-Ischaemic EncephalopathyIzabela Zdolińska-Malinowska0Dariusz Boruczkowski1Dominika Hołowaty2Paweł Krajewski3Emilian Snarski4Polski Bank Komórek Macierzystych S.A. (FamiCord Group)Polski Bank Komórek Macierzystych S.A. (FamiCord Group)Department of Obstetrics and GynecologyDepartment of Obstetrics and GynecologyPolski Bank Komórek Macierzystych S.A. (FamiCord Group)Hypoxic-ischaemic encephalopathy (HIE) is a severe complication of asphyxia at birth. Therapeutic hypothermia, the standard method for HIE prevention, is effective in only 50% of the cases. As the understanding of the immunological basis of these changes increases, experiments have begun with the use of cord blood (CB) because of its neuroprotective properties. Mechanisms for the neuroprotective effects of CB stem cells include antiapoptotic and anti-inflammatory actions, stimulation of angiogenesis, production of trophic factors, and mitochondrial donation. In several animal models of HIE, CB decreased oxidative stress, cell death markers, CD4+ T cell infiltration, and microglial activation; restored normal brain metabolic activity; promoted neurogenesis; improved myelination; and increased the proportion of mature oligodendrocytes, neuron numbers in the motor cortex and somatosensory cortex, and brain weight. These observations translate into motor strength, limb function, gait, and cognitive function and behaviour. In humans, the efficacy and safety of CB administration were reported in a few early clinical studies which confirmed the feasibility and safety of this intervention for up to 10 years. The results of these studies showed an improvement in the developmental outcomes over hypothermia. Two phase-2 clinical studies are ongoing under the United States regulations, namely one controlled study and one blinded study.http://dx.doi.org/10.1155/2022/9125460 |
| spellingShingle | Izabela Zdolińska-Malinowska Dariusz Boruczkowski Dominika Hołowaty Paweł Krajewski Emilian Snarski Rationale for the Use of Cord Blood in Hypoxic-Ischaemic Encephalopathy Stem Cells International |
| title | Rationale for the Use of Cord Blood in Hypoxic-Ischaemic Encephalopathy |
| title_full | Rationale for the Use of Cord Blood in Hypoxic-Ischaemic Encephalopathy |
| title_fullStr | Rationale for the Use of Cord Blood in Hypoxic-Ischaemic Encephalopathy |
| title_full_unstemmed | Rationale for the Use of Cord Blood in Hypoxic-Ischaemic Encephalopathy |
| title_short | Rationale for the Use of Cord Blood in Hypoxic-Ischaemic Encephalopathy |
| title_sort | rationale for the use of cord blood in hypoxic ischaemic encephalopathy |
| url | http://dx.doi.org/10.1155/2022/9125460 |
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