Failure of daratumumab in the treatment of anti-synthetase syndrome: A case report
Anti-synthetase syndrome is a subset of idiopathic inflammatory myopathies, for which refractory disease can be difficult to treat. Daratumumab, an anti-CD38 monoclonal antibody primarily used in hematologic malignancies, has recently shown promise in very few case reports of refractory idiopathic i...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-04-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X251336022 |
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| author | Nam Nguyen Valérie Leclair Rayan Kaedbey Marie Hudson |
| author_facet | Nam Nguyen Valérie Leclair Rayan Kaedbey Marie Hudson |
| author_sort | Nam Nguyen |
| collection | DOAJ |
| description | Anti-synthetase syndrome is a subset of idiopathic inflammatory myopathies, for which refractory disease can be difficult to treat. Daratumumab, an anti-CD38 monoclonal antibody primarily used in hematologic malignancies, has recently shown promise in very few case reports of refractory idiopathic inflammatory myopathies. We present a case of a 44-year-old man with anti-Jo1 anti-synthetase syndrome with concurrent anti-Ro52, in which myositis remained refractory to multiple immunosuppressants. Despite treatment with daratumumab, the patient did not respond and ultimately succumbed to infection. This case underscores the need for further research to better define the role of daratumumab in idiopathic inflammatory myopathies and identify predictors of treatment response. |
| format | Article |
| id | doaj-art-80a8ff56f20743b2afd915aff805671a |
| institution | OA Journals |
| issn | 2050-313X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj-art-80a8ff56f20743b2afd915aff805671a2025-08-20T02:13:27ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2025-04-011310.1177/2050313X251336022Failure of daratumumab in the treatment of anti-synthetase syndrome: A case reportNam Nguyen0Valérie Leclair1Rayan Kaedbey2Marie Hudson3Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, CanadaDivision of Rheumatology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, CanadaDivision of Hematology, Jewish General Hospital, Montreal, QC, CanadaDivision of Rheumatology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, CanadaAnti-synthetase syndrome is a subset of idiopathic inflammatory myopathies, for which refractory disease can be difficult to treat. Daratumumab, an anti-CD38 monoclonal antibody primarily used in hematologic malignancies, has recently shown promise in very few case reports of refractory idiopathic inflammatory myopathies. We present a case of a 44-year-old man with anti-Jo1 anti-synthetase syndrome with concurrent anti-Ro52, in which myositis remained refractory to multiple immunosuppressants. Despite treatment with daratumumab, the patient did not respond and ultimately succumbed to infection. This case underscores the need for further research to better define the role of daratumumab in idiopathic inflammatory myopathies and identify predictors of treatment response.https://doi.org/10.1177/2050313X251336022 |
| spellingShingle | Nam Nguyen Valérie Leclair Rayan Kaedbey Marie Hudson Failure of daratumumab in the treatment of anti-synthetase syndrome: A case report SAGE Open Medical Case Reports |
| title | Failure of daratumumab in the treatment of anti-synthetase syndrome: A case report |
| title_full | Failure of daratumumab in the treatment of anti-synthetase syndrome: A case report |
| title_fullStr | Failure of daratumumab in the treatment of anti-synthetase syndrome: A case report |
| title_full_unstemmed | Failure of daratumumab in the treatment of anti-synthetase syndrome: A case report |
| title_short | Failure of daratumumab in the treatment of anti-synthetase syndrome: A case report |
| title_sort | failure of daratumumab in the treatment of anti synthetase syndrome a case report |
| url | https://doi.org/10.1177/2050313X251336022 |
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