Effects of Eight Weeks of Endurance and Resistance Training on Serum Level of Apoptotic Indicators in Elderly Women
Introduction: The elderly's increased apoptosis causes physical function decline and quality of life loss, requiring non-pharmacological apoptosis regulation techniques. The present study was aimed at examining the effects of eight weeks of endurance and resistance training on apoptotic marker...
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Ilam University of Medical Sciences
2025-07-01
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| Series: | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām |
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| Online Access: | http://sjimu.medilam.ac.ir/article-1-8561-en.pdf |
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| author | Parvin Mortezaei Sajad Arshadi Abdolali Banaeifar Mojtaba Izadi |
| author_facet | Parvin Mortezaei Sajad Arshadi Abdolali Banaeifar Mojtaba Izadi |
| author_sort | Parvin Mortezaei |
| collection | DOAJ |
| description | Introduction: The elderly's increased apoptosis causes physical function decline and quality of life loss, requiring non-pharmacological apoptosis regulation techniques. The present study was aimed at examining the effects of eight weeks of endurance and resistance training on apoptotic markers in elderly women.
Materials & Methods: A study involving 39 women over 60 years old was conducted to measure their fitness levels. The participants were divided into three groups: endurance training, resistance training, and control. The endurance training involved walking on a treadmill at 40-70% of maximum heart rate, while the resistance training involved movements with body weight and light dumbbells at 40-70% of one repetition maximum. The exercises were performed in three 20-35-minute sessions per week for eight weeks. Blood samples were collected before and after the intervention, and serum BAX and BCL2 levels were measured using ELISA. SPSS V.21, Shapiro-Wilk test, two-way mixed analysis of variance, and Bonferroni post hoc test were employed for statistical analysis (p<0.05).
Results: Both endurance and resistance training resulted in significant decreases in serum levels of the proapoptotic protein BAX and the BAX/BCL2 ratio, as well as significant increases in the antiapoptotic protein BCL2 (P < 0.05). A comparison between the two training groups showed that resistance training produced a greater decrease in BAX, while endurance training produced a greater increase in BCL2. This difference in protein response between the two training types was statistically significant (P = 0.026).
Conclusion: Regular physical activity, particularly endurance and resistance training, may be an effective non-pharmacological strategy for enhancing cellular health and modulating apoptotic processes in older adults. |
| format | Article |
| id | doaj-art-80a8b5d12bac46f1a9de4e1443efb06b |
| institution | Kabale University |
| issn | 1563-4728 2588-3135 |
| language | fas |
| publishDate | 2025-07-01 |
| publisher | Ilam University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām |
| spelling | doaj-art-80a8b5d12bac46f1a9de4e1443efb06b2025-08-25T07:35:14ZfasIlam University of Medical SciencesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām1563-47282588-31352025-07-0133397112Effects of Eight Weeks of Endurance and Resistance Training on Serum Level of Apoptotic Indicators in Elderly WomenParvin Mortezaei0Sajad Arshadi1Abdolali Banaeifar2Mojtaba Izadi3 Dept of Exercise Physiology, South Tehran Branch, Islamic Azad University, Tehran, Iran Dept of Exercise Physiology, South Tehran Branch, Islamic Azad University, Tehran, Iran Dept of Exercise Physiology, South Tehran Branch, Islamic Azad University, Tehran, Iran Dept of Exercise Physiology, Saveh Branch, Islamic Azad University, Tehran. Iran Introduction: The elderly's increased apoptosis causes physical function decline and quality of life loss, requiring non-pharmacological apoptosis regulation techniques. The present study was aimed at examining the effects of eight weeks of endurance and resistance training on apoptotic markers in elderly women. Materials & Methods: A study involving 39 women over 60 years old was conducted to measure their fitness levels. The participants were divided into three groups: endurance training, resistance training, and control. The endurance training involved walking on a treadmill at 40-70% of maximum heart rate, while the resistance training involved movements with body weight and light dumbbells at 40-70% of one repetition maximum. The exercises were performed in three 20-35-minute sessions per week for eight weeks. Blood samples were collected before and after the intervention, and serum BAX and BCL2 levels were measured using ELISA. SPSS V.21, Shapiro-Wilk test, two-way mixed analysis of variance, and Bonferroni post hoc test were employed for statistical analysis (p<0.05). Results: Both endurance and resistance training resulted in significant decreases in serum levels of the proapoptotic protein BAX and the BAX/BCL2 ratio, as well as significant increases in the antiapoptotic protein BCL2 (P < 0.05). A comparison between the two training groups showed that resistance training produced a greater decrease in BAX, while endurance training produced a greater increase in BCL2. This difference in protein response between the two training types was statistically significant (P = 0.026). Conclusion: Regular physical activity, particularly endurance and resistance training, may be an effective non-pharmacological strategy for enhancing cellular health and modulating apoptotic processes in older adults.http://sjimu.medilam.ac.ir/article-1-8561-en.pdfresistance trainingendurance trainingapoptosisaging |
| spellingShingle | Parvin Mortezaei Sajad Arshadi Abdolali Banaeifar Mojtaba Izadi Effects of Eight Weeks of Endurance and Resistance Training on Serum Level of Apoptotic Indicators in Elderly Women Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām resistance training endurance training apoptosis aging |
| title | Effects of Eight Weeks of Endurance and Resistance Training on Serum Level of Apoptotic Indicators in Elderly Women |
| title_full | Effects of Eight Weeks of Endurance and Resistance Training on Serum Level of Apoptotic Indicators in Elderly Women |
| title_fullStr | Effects of Eight Weeks of Endurance and Resistance Training on Serum Level of Apoptotic Indicators in Elderly Women |
| title_full_unstemmed | Effects of Eight Weeks of Endurance and Resistance Training on Serum Level of Apoptotic Indicators in Elderly Women |
| title_short | Effects of Eight Weeks of Endurance and Resistance Training on Serum Level of Apoptotic Indicators in Elderly Women |
| title_sort | effects of eight weeks of endurance and resistance training on serum level of apoptotic indicators in elderly women |
| topic | resistance training endurance training apoptosis aging |
| url | http://sjimu.medilam.ac.ir/article-1-8561-en.pdf |
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