Polygenic risk scores in cardiovascular risk prediction: A cohort study and modelling analyses.

Polygenic risk scores in cardiovascular risk prediction: A cohort study and modelling analyses.

<h4>Background</h4>Polygenic risk scores (PRSs) can stratify populations into cardiovascular disease (CVD) risk groups. We aimed to quantify the potential advantage of adding information on PRSs to conventional risk factors in the primary prevention of CVD.<h4>Methods and findings&...

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Main Authors: Luanluan Sun, Lisa Pennells, Stephen Kaptoge, Christopher P Nelson, Scott C Ritchie, Gad Abraham, Matthew Arnold, Steven Bell, Thomas Bolton, Stephen Burgess, Frank Dudbridge, Qi Guo, Eleni Sofianopoulou, David Stevens, John R Thompson, Adam S Butterworth, Angela Wood, John Danesh, Nilesh J Samani, Michael Inouye, Emanuele Di Angelantonio
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS Medicine
Online Access:https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1003498&type=printable
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