Correlation of Vitreous Vascular Endothelial Growth Factor and Uric Acid Concentration Using Optical Coherence Tomography in Diabetic Macular Edema
Purpose. We investigated two factors linked to diabetic macular edema (DME), vitreous and serum levels of vascular endothelial growth factor (VEGF) and uric acid (UA) in patients with DME, and compared the results with changes in optical coherence tomography (OCT) and visual acuity (VA). Methods. A...
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Wiley
2015-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2015/478509 |
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| author | Libuse Krizova Marta Kalousova Ales Antonin Kubena Oldrich Chrapek Barbora Chrapkova Martin Sin Tomas Zima |
| author_facet | Libuse Krizova Marta Kalousova Ales Antonin Kubena Oldrich Chrapek Barbora Chrapkova Martin Sin Tomas Zima |
| author_sort | Libuse Krizova |
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| description | Purpose. We investigated two factors linked to diabetic macular edema (DME), vitreous and serum levels of vascular endothelial growth factor (VEGF) and uric acid (UA) in patients with DME, and compared the results with changes in optical coherence tomography (OCT) and visual acuity (VA). Methods. A prospective study of 29 eyes, 16 cystoid DME and nonproliferative diabetic retinopathy (DR) and 13 nondiabetic controls. Biochemical analysis of vitreous and serum samples was performed and OCT scans were graded according to central retinal thickness (CRT), cube volume (CV), cube average thickness (CAT), and serous retinal detachment (SRD). Results. In DME group, intravitreal concentrations of VEGF (p<0.001), UA (p=0.038), and total protein (p<0.001) were significantly higher than in control group. In DME subjects, intravitreal UA correlated significantly with intravitreal VEGF (ƍ = 0.559, p=0.03) but not with total vitreous protein and serum UA. Increased intravitreal VEGF in DME group correlated with increase in CV (ƍ = 0.515/p=0.041). None of the OCT parameters correlated with the VA. Conclusions. The results suggest that the CV might be assessor of anti-VEGF therapy efficacy. Second, apart from VEGF, the role of UA in the pathogenesis and progression of DR should be considered. |
| format | Article |
| id | doaj-art-809f6e3d35b543c7b3ecc87ac790eba0 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-809f6e3d35b543c7b3ecc87ac790eba02025-02-03T05:47:14ZengWileyJournal of Ophthalmology2090-004X2090-00582015-01-01201510.1155/2015/478509478509Correlation of Vitreous Vascular Endothelial Growth Factor and Uric Acid Concentration Using Optical Coherence Tomography in Diabetic Macular EdemaLibuse Krizova0Marta Kalousova1Ales Antonin Kubena2Oldrich Chrapek3Barbora Chrapkova4Martin Sin5Tomas Zima6Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital, U Nemocnice 2, 128 08 Prague 2, Czech RepublicInstitute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital, U Nemocnice 2, 128 08 Prague 2, Czech RepublicInstitute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital, U Nemocnice 2, 128 08 Prague 2, Czech RepublicDepartment of Ophthalmology, Faculty of Medicine and Dentistry, Palacky University Olomouc, I. P. Pavlova 6, 775 20 Olomouc, Czech RepublicDepartment of Ophthalmology, Faculty of Medicine and Dentistry, Palacky University Olomouc, I. P. Pavlova 6, 775 20 Olomouc, Czech RepublicDepartment of Ophthalmology, Faculty of Medicine and Dentistry, Palacky University Olomouc, I. P. Pavlova 6, 775 20 Olomouc, Czech RepublicInstitute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital, U Nemocnice 2, 128 08 Prague 2, Czech RepublicPurpose. We investigated two factors linked to diabetic macular edema (DME), vitreous and serum levels of vascular endothelial growth factor (VEGF) and uric acid (UA) in patients with DME, and compared the results with changes in optical coherence tomography (OCT) and visual acuity (VA). Methods. A prospective study of 29 eyes, 16 cystoid DME and nonproliferative diabetic retinopathy (DR) and 13 nondiabetic controls. Biochemical analysis of vitreous and serum samples was performed and OCT scans were graded according to central retinal thickness (CRT), cube volume (CV), cube average thickness (CAT), and serous retinal detachment (SRD). Results. In DME group, intravitreal concentrations of VEGF (p<0.001), UA (p=0.038), and total protein (p<0.001) were significantly higher than in control group. In DME subjects, intravitreal UA correlated significantly with intravitreal VEGF (ƍ = 0.559, p=0.03) but not with total vitreous protein and serum UA. Increased intravitreal VEGF in DME group correlated with increase in CV (ƍ = 0.515/p=0.041). None of the OCT parameters correlated with the VA. Conclusions. The results suggest that the CV might be assessor of anti-VEGF therapy efficacy. Second, apart from VEGF, the role of UA in the pathogenesis and progression of DR should be considered.http://dx.doi.org/10.1155/2015/478509 |
| spellingShingle | Libuse Krizova Marta Kalousova Ales Antonin Kubena Oldrich Chrapek Barbora Chrapkova Martin Sin Tomas Zima Correlation of Vitreous Vascular Endothelial Growth Factor and Uric Acid Concentration Using Optical Coherence Tomography in Diabetic Macular Edema Journal of Ophthalmology |
| title | Correlation of Vitreous Vascular Endothelial Growth Factor and Uric Acid Concentration Using Optical Coherence Tomography in Diabetic Macular Edema |
| title_full | Correlation of Vitreous Vascular Endothelial Growth Factor and Uric Acid Concentration Using Optical Coherence Tomography in Diabetic Macular Edema |
| title_fullStr | Correlation of Vitreous Vascular Endothelial Growth Factor and Uric Acid Concentration Using Optical Coherence Tomography in Diabetic Macular Edema |
| title_full_unstemmed | Correlation of Vitreous Vascular Endothelial Growth Factor and Uric Acid Concentration Using Optical Coherence Tomography in Diabetic Macular Edema |
| title_short | Correlation of Vitreous Vascular Endothelial Growth Factor and Uric Acid Concentration Using Optical Coherence Tomography in Diabetic Macular Edema |
| title_sort | correlation of vitreous vascular endothelial growth factor and uric acid concentration using optical coherence tomography in diabetic macular edema |
| url | http://dx.doi.org/10.1155/2015/478509 |
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