Myelopoiesis and Myeloid Leukaemogenesis in the Zebrafish
Over the past ten years, studies using the zebrafish model have contributed to our understanding of vertebrate haematopoiesis, myelopoiesis, and myeloid leukaemogenesis. Novel insights into the conservation of haematopoietic lineages and improvements in our capacity to identify, isolate, and culture...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2012/358518 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850214587181301760 |
|---|---|
| author | A. Michael Forrester Jason N. Berman Elspeth M. Payne |
| author_facet | A. Michael Forrester Jason N. Berman Elspeth M. Payne |
| author_sort | A. Michael Forrester |
| collection | DOAJ |
| description | Over the past ten years, studies using the zebrafish model have contributed to our understanding of vertebrate haematopoiesis, myelopoiesis, and myeloid leukaemogenesis. Novel insights into the conservation of haematopoietic lineages and improvements in our capacity to identify, isolate, and culture such haematopoietic cells continue to enhance our ability to use this simple organism to address disease biology. Coupled with the strengths of the zebrafish embryo to dissect developmental myelopoiesis and the continually expanding repertoire of models of myeloid malignancies, this versatile organism has established its niche as a valuable tool to address key questions in the field of myelopoiesis and myeloid leukaemogenesis. In this paper, we address the recent advances and future directions in the field of myelopoiesis and leukaemogenesis using the zebrafish system. |
| format | Article |
| id | doaj-art-809e7e1945904c2d95c5499dbdcb067e |
| institution | OA Journals |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-809e7e1945904c2d95c5499dbdcb067e2025-08-20T02:08:50ZengWileyAdvances in Hematology1687-91041687-91122012-01-01201210.1155/2012/358518358518Myelopoiesis and Myeloid Leukaemogenesis in the ZebrafishA. Michael Forrester0Jason N. Berman1Elspeth M. Payne2Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, B3H 3J5, CanadaDepartments of Pediatrics, Microbiology and Immunology, and Pathology, Dalhousie University, Halifax, NS, B3H 3J5, CanadaDepartment of Haematology, UCL Cancer Institute, School of Life and Medical Sciences, University College London, London WC1E 6BT, UKOver the past ten years, studies using the zebrafish model have contributed to our understanding of vertebrate haematopoiesis, myelopoiesis, and myeloid leukaemogenesis. Novel insights into the conservation of haematopoietic lineages and improvements in our capacity to identify, isolate, and culture such haematopoietic cells continue to enhance our ability to use this simple organism to address disease biology. Coupled with the strengths of the zebrafish embryo to dissect developmental myelopoiesis and the continually expanding repertoire of models of myeloid malignancies, this versatile organism has established its niche as a valuable tool to address key questions in the field of myelopoiesis and myeloid leukaemogenesis. In this paper, we address the recent advances and future directions in the field of myelopoiesis and leukaemogenesis using the zebrafish system.http://dx.doi.org/10.1155/2012/358518 |
| spellingShingle | A. Michael Forrester Jason N. Berman Elspeth M. Payne Myelopoiesis and Myeloid Leukaemogenesis in the Zebrafish Advances in Hematology |
| title | Myelopoiesis and Myeloid Leukaemogenesis in the Zebrafish |
| title_full | Myelopoiesis and Myeloid Leukaemogenesis in the Zebrafish |
| title_fullStr | Myelopoiesis and Myeloid Leukaemogenesis in the Zebrafish |
| title_full_unstemmed | Myelopoiesis and Myeloid Leukaemogenesis in the Zebrafish |
| title_short | Myelopoiesis and Myeloid Leukaemogenesis in the Zebrafish |
| title_sort | myelopoiesis and myeloid leukaemogenesis in the zebrafish |
| url | http://dx.doi.org/10.1155/2012/358518 |
| work_keys_str_mv | AT amichaelforrester myelopoiesisandmyeloidleukaemogenesisinthezebrafish AT jasonnberman myelopoiesisandmyeloidleukaemogenesisinthezebrafish AT elspethmpayne myelopoiesisandmyeloidleukaemogenesisinthezebrafish |