Lipids in parenteral nutrition – expert consensus statements: Translating guidelines into clinical practice
Summary: Lipids are integral to parenteral nutrition (PN) in all settings where PN is required, serving as a source of energy and essential fatty acids. In addition, lipids modulate a variety of biological functions, including inflammatory and immune responses. Moreover, fish oil (FO), which contain...
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Elsevier
2025-04-01
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| Series: | Clinical Nutrition Open Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266726852500004X |
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| author | Robert G. Martindale Philip C. Calder Sarah V. Cogle David C. Evans Leah Gramlich Stephen A. McClave Manpreet S. Mundi Maurizio Muscaritoli Reid Nishikawa Jayshil Patel Lorenzo Pradelli Martin Rosenthal Christian Stoppe Kelly A. Tappenden Malissa Warren Dan Waitzberg Paul E. Wischmeyer Stanislaw Klek |
| author_facet | Robert G. Martindale Philip C. Calder Sarah V. Cogle David C. Evans Leah Gramlich Stephen A. McClave Manpreet S. Mundi Maurizio Muscaritoli Reid Nishikawa Jayshil Patel Lorenzo Pradelli Martin Rosenthal Christian Stoppe Kelly A. Tappenden Malissa Warren Dan Waitzberg Paul E. Wischmeyer Stanislaw Klek |
| author_sort | Robert G. Martindale |
| collection | DOAJ |
| description | Summary: Lipids are integral to parenteral nutrition (PN) in all settings where PN is required, serving as a source of energy and essential fatty acids. In addition, lipids modulate a variety of biological functions, including inflammatory and immune responses. Moreover, fish oil (FO), which contains omega-3 fatty acids, has become an important component of modern lipid emulsions. The Lipids in PN Summit involved a panel of international experts with extensive clinical experience in PN use. They assessed the current state of knowledge and developed expert consensus statements regarding the use of lipid emulsions in patients requiring PN. This summit built upon outcomes from an earlier summit, and focused on adult patients in three distinct clinical settings: intensive care units, hospital wards, and the home environment/long-term PN. The summit workflow included identification and appraisal of scientific and clinical literature, the exchange of practical clinical experience, and the formulation of consensus statements. The latter aim to assist healthcare professionals in their decision-making processes in daily practice by providing practical guidance related to providing lipid emulsions as part of PN. This article briefly summarizes the biological effects of lipids used in PN, and then focuses on the rationale for their use in three distinct adult PN settings. Expert consensus statements are also provided, helping to bridge gaps between evidence and clinical practice, and thus complementing formal PN guideline recommendations. There is accumulating evidence suggesting that PN including FO confers clinically meaningful advantages compared with PN without FO, and has a favorable risk–benefit ratio. |
| format | Article |
| id | doaj-art-809a4b1c6b0341a29e2eede9fb3fbff0 |
| institution | Kabale University |
| issn | 2667-2685 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Nutrition Open Science |
| spelling | doaj-art-809a4b1c6b0341a29e2eede9fb3fbff02025-02-09T05:01:39ZengElsevierClinical Nutrition Open Science2667-26852025-04-01605065Lipids in parenteral nutrition – expert consensus statements: Translating guidelines into clinical practiceRobert G. Martindale0Philip C. Calder1Sarah V. Cogle2David C. Evans3Leah Gramlich4Stephen A. McClave5Manpreet S. Mundi6Maurizio Muscaritoli7Reid Nishikawa8Jayshil Patel9Lorenzo Pradelli10Martin Rosenthal11Christian Stoppe12Kelly A. Tappenden13Malissa Warren14Dan Waitzberg15Paul E. Wischmeyer16Stanislaw Klek17Department of Surgery, Oregon Health and Science University, Portland, OR, USA; Corresponding author.Faculty of Medicine, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UKDepartment of Pharmacy, Clinical Programs, Vanderbilt University Medical Center, Nashville, TN, USANutrition Support Service, OhioHealth, Columbus, OH, USADepartment of Medicine, Royal Alexandra Hospital, University of Alberta, Edmonton, Alberta, CanadaDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville School of Medicine, University of Louisville, Louisville, KY, USADivision of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, 200 1st St. SW, Rochester, MN, 55905, USADepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, ItalyNutrishare, LLC, Elk Grove, CA, USADivision of Pulmonary and Critical Care Medicine, Medical College of Wisconsin, Milwaukee, WI, USAAdRes-Health Economics and Outcome Research, Turin, ItalyDepartment of Surgery, Division of Trauma and Acute Care Surgery, University of Florida College of Medicine, Gainesville, FL, USAUniversity Hospital Wuerzburg, Department of Anesthesiology, Intensive Care, Emergency, and Pain Medicine, Germany; Department of Cardiac Anesthesiology and Intensive Care Medicine, Charité Berlin, Berlin, GermanyCollege of Health, University of Utah, Salt Lake City, UT, USADepartment of Surgery, Oregon Health and Science University, Portland, OR, USA; Nutrition and Food Service Portland, VA Health Care System, Portland, OR, USADepartment of Gastroenterology (LIM-35), School of Medicine, University of Sao Paulo, Sao Paulo, BrazilDivision of Anesthesiology and Critical Care Medicine, Duke University Hospital, Durham, NC, USASurgical Oncology Clinic, The Maria Sklodowska-Curie National Cancer Institute, Krakow, PolandSummary: Lipids are integral to parenteral nutrition (PN) in all settings where PN is required, serving as a source of energy and essential fatty acids. In addition, lipids modulate a variety of biological functions, including inflammatory and immune responses. Moreover, fish oil (FO), which contains omega-3 fatty acids, has become an important component of modern lipid emulsions. The Lipids in PN Summit involved a panel of international experts with extensive clinical experience in PN use. They assessed the current state of knowledge and developed expert consensus statements regarding the use of lipid emulsions in patients requiring PN. This summit built upon outcomes from an earlier summit, and focused on adult patients in three distinct clinical settings: intensive care units, hospital wards, and the home environment/long-term PN. The summit workflow included identification and appraisal of scientific and clinical literature, the exchange of practical clinical experience, and the formulation of consensus statements. The latter aim to assist healthcare professionals in their decision-making processes in daily practice by providing practical guidance related to providing lipid emulsions as part of PN. This article briefly summarizes the biological effects of lipids used in PN, and then focuses on the rationale for their use in three distinct adult PN settings. Expert consensus statements are also provided, helping to bridge gaps between evidence and clinical practice, and thus complementing formal PN guideline recommendations. There is accumulating evidence suggesting that PN including FO confers clinically meaningful advantages compared with PN without FO, and has a favorable risk–benefit ratio.http://www.sciencedirect.com/science/article/pii/S266726852500004XConsensusFish oilGuidelinesLipidsParenteral nutritionSummit |
| spellingShingle | Robert G. Martindale Philip C. Calder Sarah V. Cogle David C. Evans Leah Gramlich Stephen A. McClave Manpreet S. Mundi Maurizio Muscaritoli Reid Nishikawa Jayshil Patel Lorenzo Pradelli Martin Rosenthal Christian Stoppe Kelly A. Tappenden Malissa Warren Dan Waitzberg Paul E. Wischmeyer Stanislaw Klek Lipids in parenteral nutrition – expert consensus statements: Translating guidelines into clinical practice Clinical Nutrition Open Science Consensus Fish oil Guidelines Lipids Parenteral nutrition Summit |
| title | Lipids in parenteral nutrition – expert consensus statements: Translating guidelines into clinical practice |
| title_full | Lipids in parenteral nutrition – expert consensus statements: Translating guidelines into clinical practice |
| title_fullStr | Lipids in parenteral nutrition – expert consensus statements: Translating guidelines into clinical practice |
| title_full_unstemmed | Lipids in parenteral nutrition – expert consensus statements: Translating guidelines into clinical practice |
| title_short | Lipids in parenteral nutrition – expert consensus statements: Translating guidelines into clinical practice |
| title_sort | lipids in parenteral nutrition expert consensus statements translating guidelines into clinical practice |
| topic | Consensus Fish oil Guidelines Lipids Parenteral nutrition Summit |
| url | http://www.sciencedirect.com/science/article/pii/S266726852500004X |
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