Mitochondrial Cardiomyopathy Presenting as Dilated Phase of Hypertrophic Cardiomyopathy Diagnosed with Histological and Genetic Analyses
We report a case with 46-year-old man diagnosed with mitochondrial cardiomyopathy in the dilated phase of hypertrophic cardiomyopathy. Since cardiac magnetic resonance imaging, beta-methyl-p-I123-iodophenyl-pentadecanoic myocardial scintigraphy, and positron emission tomography/computed tomography r...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Cardiology |
| Online Access: | http://dx.doi.org/10.1155/2017/9473917 |
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| author | Toshiki Kuno Syohei Imaeda Yohei Asakawa Hiroshi Nakamura Genzou Takemura Daisuke Asahara Akira Kanamori Tomoyuki Kabutoya Yohei Numasawa |
| author_facet | Toshiki Kuno Syohei Imaeda Yohei Asakawa Hiroshi Nakamura Genzou Takemura Daisuke Asahara Akira Kanamori Tomoyuki Kabutoya Yohei Numasawa |
| author_sort | Toshiki Kuno |
| collection | DOAJ |
| description | We report a case with 46-year-old man diagnosed with mitochondrial cardiomyopathy in the dilated phase of hypertrophic cardiomyopathy. Since cardiac magnetic resonance imaging, beta-methyl-p-I123-iodophenyl-pentadecanoic myocardial scintigraphy, and positron emission tomography/computed tomography revealed no remarkable findings, we performed electron microscopic examination, which aided in diagnosing mitochondrial cardiomyopathy. Muscle biopsy was also compatible with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes and DNA analysis also concluded it. Since muscle biopsy is less invasive for patients compared to endomyocardial biopsy, cardiologists need to consider it. The diagnosis of mitochondrial cardiomyopathy is helpful because it is a genetic condition and also for consideration of device therapy, as well as management for acute crisis. |
| format | Article |
| id | doaj-art-8098b8811b584778a1e5cfb23844cce5 |
| institution | Kabale University |
| issn | 2090-6404 2090-6412 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Cardiology |
| spelling | doaj-art-8098b8811b584778a1e5cfb23844cce52025-02-03T06:01:22ZengWileyCase Reports in Cardiology2090-64042090-64122017-01-01201710.1155/2017/94739179473917Mitochondrial Cardiomyopathy Presenting as Dilated Phase of Hypertrophic Cardiomyopathy Diagnosed with Histological and Genetic AnalysesToshiki Kuno0Syohei Imaeda1Yohei Asakawa2Hiroshi Nakamura3Genzou Takemura4Daisuke Asahara5Akira Kanamori6Tomoyuki Kabutoya7Yohei Numasawa8Department of Cardiology, Japanese Red Cross Ashikaga Hospital, Ashikaga, JapanDepartment of Cardiology, Japanese Red Cross Ashikaga Hospital, Ashikaga, JapanDepartment of Neurology, Japanese Red Cross Ashikaga Hospital, Ashikaga, JapanDepartment of General Internal Medicine, Hiroshima-Nishi Medical Center, Ohtake, JapanDepartment of Internal Medicine, Asahi School of Dentistry University, Mizuho, JapanDepartment of Neurology, Japanese Red Cross Ashikaga Hospital, Ashikaga, JapanDepartment of Gastroenterology, Japanese Red Cross Ashikaga Hospital, Ashikaga, JapanDepartment of Cardiology, Jichi Medical University, Shimotsuke, JapanDepartment of Cardiology, Japanese Red Cross Ashikaga Hospital, Ashikaga, JapanWe report a case with 46-year-old man diagnosed with mitochondrial cardiomyopathy in the dilated phase of hypertrophic cardiomyopathy. Since cardiac magnetic resonance imaging, beta-methyl-p-I123-iodophenyl-pentadecanoic myocardial scintigraphy, and positron emission tomography/computed tomography revealed no remarkable findings, we performed electron microscopic examination, which aided in diagnosing mitochondrial cardiomyopathy. Muscle biopsy was also compatible with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes and DNA analysis also concluded it. Since muscle biopsy is less invasive for patients compared to endomyocardial biopsy, cardiologists need to consider it. The diagnosis of mitochondrial cardiomyopathy is helpful because it is a genetic condition and also for consideration of device therapy, as well as management for acute crisis.http://dx.doi.org/10.1155/2017/9473917 |
| spellingShingle | Toshiki Kuno Syohei Imaeda Yohei Asakawa Hiroshi Nakamura Genzou Takemura Daisuke Asahara Akira Kanamori Tomoyuki Kabutoya Yohei Numasawa Mitochondrial Cardiomyopathy Presenting as Dilated Phase of Hypertrophic Cardiomyopathy Diagnosed with Histological and Genetic Analyses Case Reports in Cardiology |
| title | Mitochondrial Cardiomyopathy Presenting as Dilated Phase of Hypertrophic Cardiomyopathy Diagnosed with Histological and Genetic Analyses |
| title_full | Mitochondrial Cardiomyopathy Presenting as Dilated Phase of Hypertrophic Cardiomyopathy Diagnosed with Histological and Genetic Analyses |
| title_fullStr | Mitochondrial Cardiomyopathy Presenting as Dilated Phase of Hypertrophic Cardiomyopathy Diagnosed with Histological and Genetic Analyses |
| title_full_unstemmed | Mitochondrial Cardiomyopathy Presenting as Dilated Phase of Hypertrophic Cardiomyopathy Diagnosed with Histological and Genetic Analyses |
| title_short | Mitochondrial Cardiomyopathy Presenting as Dilated Phase of Hypertrophic Cardiomyopathy Diagnosed with Histological and Genetic Analyses |
| title_sort | mitochondrial cardiomyopathy presenting as dilated phase of hypertrophic cardiomyopathy diagnosed with histological and genetic analyses |
| url | http://dx.doi.org/10.1155/2017/9473917 |
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