Solid-phase synthesis of negatively charged oligomeric polyamide mimetics of nucleic acids
A Boc-protocol for manual solid-phase synthesis of novel sequences of negatively charged oligomeric polyamide mimetics of nucleic acids with a regular structure of the pseudopeptide backbone based on L-glutamic acid and glycine and having various positions of the carbethoxyethyl moiety was developed...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
MIREA - Russian Technological University
2011-04-01
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| Series: | Тонкие химические технологии |
| Subjects: | |
| Online Access: | https://www.finechem-mirea.ru/jour/article/view/867 |
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| Summary: | A Boc-protocol for manual solid-phase synthesis of novel sequences of negatively charged oligomeric polyamide mimetics of nucleic acids with a regular structure of the pseudopeptide backbone based on L-glutamic acid and glycine and having various positions of the carbethoxyethyl moiety was developed. Conditions for their cleavage from polymeric carrier, isolation and structure confirmation are presented. |
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| ISSN: | 2410-6593 2686-7575 |