DOMINÓ Registry: study protocol on mineral and bone disease (DOença MINeral e Óssea) of chronic kidney disease in pediatrics in Brazil
Abstract Introduction: Pediatric patients with chronic kidney disease (CKD) develop mineral and bone disorders (MBD). We do not have Brazilian data that evaluate these outcomes, which can be obtained through epidemiological records. Objective: To present the DOMINÓ study, which aims to describe CK...
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| Format: | Article |
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Sociedade Brasileira de Nefrologia
2024-12-01
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| Series: | Brazilian Journal of Nephrology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002025000100701&lng=en&tlng=en |
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| author | Emília Maria Dantas Soeiro Maria Goretti Moreira Guimarães Penido Lucimary de Castro Sylvestre Maria Cristina Andrade Suzana Aparecida Greggi de Alcantara Ivan Coelho Machado Leonardo Gonçalves Bedram Ana Lucia Santos Abreu |
| author_facet | Emília Maria Dantas Soeiro Maria Goretti Moreira Guimarães Penido Lucimary de Castro Sylvestre Maria Cristina Andrade Suzana Aparecida Greggi de Alcantara Ivan Coelho Machado Leonardo Gonçalves Bedram Ana Lucia Santos Abreu |
| author_sort | Emília Maria Dantas Soeiro |
| collection | DOAJ |
| description | Abstract Introduction: Pediatric patients with chronic kidney disease (CKD) develop mineral and bone disorders (MBD). We do not have Brazilian data that evaluate these outcomes, which can be obtained through epidemiological records. Objective: To present the DOMINÓ study, which aims to describe CKD-MBD characteristics in Brazilian pediatric patients. Methods: Retrospective and prospective, multicenter, observational cohort. The retrospective study will analyze data from prevalent patients in 2024, and the prospective study will analyze data from 2025 onwards. Demographic, clinical, laboratory, imaging, and bone biopsy data will be collected from pediatric patients with CKD-MBD < 18 years old with CKD stage 3-5D and kidney transplant recipients. The Ethics Committees of the participating centers approved the study. Discussion/conclusion: The DOMINÓ study will provide information on the incidence, prevalence, morbidity, treatment results, and mortality of this pediatric disease in Brazil. Future analyses will allow us to identify predictors of response to treatment and improve the care for these patients. |
| format | Article |
| id | doaj-art-80949cbdbf46488b9105cbf60a51820b |
| institution | Kabale University |
| issn | 2175-8239 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Sociedade Brasileira de Nefrologia |
| record_format | Article |
| series | Brazilian Journal of Nephrology |
| spelling | doaj-art-80949cbdbf46488b9105cbf60a51820b2025-01-07T07:38:22ZengSociedade Brasileira de NefrologiaBrazilian Journal of Nephrology2175-82392024-12-0147110.1590/2175-8239-jbn-2024-0054enDOMINÓ Registry: study protocol on mineral and bone disease (DOença MINeral e Óssea) of chronic kidney disease in pediatrics in BrazilEmília Maria Dantas Soeirohttps://orcid.org/0000-0002-0491-6783Maria Goretti Moreira Guimarães Penidohttps://orcid.org/0000-0002-1534-3861Lucimary de Castro Sylvestrehttps://orcid.org/0000-0002-6719-6509Maria Cristina Andradehttps://orcid.org/0000-0003-4519-0613Suzana Aparecida Greggi de Alcantarahttps://orcid.org/0009-0006-9230-511XIvan Coelho Machadohttps://orcid.org/0000-0002-4810-6643Leonardo Gonçalves Bedramhttps://orcid.org/0000-0001-6210-3062Ana Lucia Santos Abreuhttps://orcid.org/0000-0002-8416-3469Abstract Introduction: Pediatric patients with chronic kidney disease (CKD) develop mineral and bone disorders (MBD). We do not have Brazilian data that evaluate these outcomes, which can be obtained through epidemiological records. Objective: To present the DOMINÓ study, which aims to describe CKD-MBD characteristics in Brazilian pediatric patients. Methods: Retrospective and prospective, multicenter, observational cohort. The retrospective study will analyze data from prevalent patients in 2024, and the prospective study will analyze data from 2025 onwards. Demographic, clinical, laboratory, imaging, and bone biopsy data will be collected from pediatric patients with CKD-MBD < 18 years old with CKD stage 3-5D and kidney transplant recipients. The Ethics Committees of the participating centers approved the study. Discussion/conclusion: The DOMINÓ study will provide information on the incidence, prevalence, morbidity, treatment results, and mortality of this pediatric disease in Brazil. Future analyses will allow us to identify predictors of response to treatment and improve the care for these patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002025000100701&lng=en&tlng=enChronic Kidney Disease-Mineral and Bone DisorderRenal Insufficiency, ChronicTreatmentDiagnosisTreatment OutcomeRegistries |
| spellingShingle | Emília Maria Dantas Soeiro Maria Goretti Moreira Guimarães Penido Lucimary de Castro Sylvestre Maria Cristina Andrade Suzana Aparecida Greggi de Alcantara Ivan Coelho Machado Leonardo Gonçalves Bedram Ana Lucia Santos Abreu DOMINÓ Registry: study protocol on mineral and bone disease (DOença MINeral e Óssea) of chronic kidney disease in pediatrics in Brazil Brazilian Journal of Nephrology Chronic Kidney Disease-Mineral and Bone Disorder Renal Insufficiency, Chronic Treatment Diagnosis Treatment Outcome Registries |
| title | DOMINÓ Registry: study protocol on mineral and bone disease (DOença MINeral e Óssea) of chronic kidney disease in pediatrics in Brazil |
| title_full | DOMINÓ Registry: study protocol on mineral and bone disease (DOença MINeral e Óssea) of chronic kidney disease in pediatrics in Brazil |
| title_fullStr | DOMINÓ Registry: study protocol on mineral and bone disease (DOença MINeral e Óssea) of chronic kidney disease in pediatrics in Brazil |
| title_full_unstemmed | DOMINÓ Registry: study protocol on mineral and bone disease (DOença MINeral e Óssea) of chronic kidney disease in pediatrics in Brazil |
| title_short | DOMINÓ Registry: study protocol on mineral and bone disease (DOença MINeral e Óssea) of chronic kidney disease in pediatrics in Brazil |
| title_sort | domino registry study protocol on mineral and bone disease doenca mineral e ossea of chronic kidney disease in pediatrics in brazil |
| topic | Chronic Kidney Disease-Mineral and Bone Disorder Renal Insufficiency, Chronic Treatment Diagnosis Treatment Outcome Registries |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002025000100701&lng=en&tlng=en |
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