Identification of cellular signatures associated with chinese hamster ovary cell adaptation for secretion of antibodies

Identification of cellular signatures associated with chinese hamster ovary cell adaptation for secretion of antibodies

The secretory capacity of Chinese hamster ovary (CHO) cells remains a fundamental bottleneck in the manufacturing of protein-based therapeutics. Unconventional biological drugs with complex structures and processing requirements are particularly problematic. Although engineered vector DNA elements c...

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Bibliographic Details
Main Authors: Ying Bai, Ivan Domenech Mercadé, Ramy Elgendy, Giulia Lambiase, Sew Peak-Chew, Catarina Franco, Steven W. Wingett, Tim J. Stevens, Luigi Grassi, Noah Hitchcock, Cristina Sayago Ferreira, Diane Hatton, Elizabeth A. Miller, Rajesh K. Mistry
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Multiomics
Chinese hamster ovary cells
Biotherapeutics
Online Access:http://www.sciencedirect.com/science/article/pii/S200103702400429X
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