Risk factors for death in patients with severe COVID-19 admitted to an intensive care unit
Aim. Severe COVID-19 is accompanied by reduced blood oxygen saturation, systemic inflammatory response syndrome and multiple organ failure, all causing a significant deterioration of homeostasis associated with death. Here we aimed to study the risk factors for death in patients with severe COVID-19...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Kemerovo State Medical University
2021-12-01
|
| Series: | Фундаментальная и клиническая медицина |
| Subjects: | |
| Online Access: | https://fcm.kemsmu.ru/jour/article/view/465 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849744358412124160 |
|---|---|
| author | N. Yu. Osyaev N. V. Ivannikova G. V. Vavin V. G. Moses O. V. Gruzdeva A. G. Kutikhin |
| author_facet | N. Yu. Osyaev N. V. Ivannikova G. V. Vavin V. G. Moses O. V. Gruzdeva A. G. Kutikhin |
| author_sort | N. Yu. Osyaev |
| collection | DOAJ |
| description | Aim. Severe COVID-19 is accompanied by reduced blood oxygen saturation, systemic inflammatory response syndrome and multiple organ failure, all causing a significant deterioration of homeostasis associated with death. Here we aimed to study the risk factors for death in patients with severe COVID-19 who have been admitted to an intensive care unit.Materials and Methods. The study included 144 consecutive patients with severe COVID-19 who have been admitted to an intensive care unit of Kuzbass Clinical Hospital from August to December 2020. Groups of survivors and non-survivors were equal in number (n = 72) and matched by gender (36 men and women) and age (median age 64 years, interquartile range 56-70 years in survivors and 58-69 years in non-survivors). Complete blood count, urinalysis, biochemical analysis, coagulation testing, and measurement of anti-SARS-CoV-2 IgM/IgG were carried out in all patients immediately upon the admission to intensive care unit.Results. Risk factors for death in severe COVID-19 at the admission to intensive care unit were arterial hypertension, chronic heart failure, peripheral atherosclerosis, impaired renal homeostasis (reduced glomerular filtration rate, elevated serum creatinine and urea, proteinuria, hematuria), augmented fasting blood glucose and lactate, neutrophilia (in men), lymphopenia and increased neutrophil-to-lymphocyte ratio (in women), and decreased IgM/IgG to SARS-CoV-2 (in women).Conclusion. We found both independent and gender-specific risk factors for death due to COVID-19. |
| format | Article |
| id | doaj-art-808e11fc861e4e5a8fe4192cf3f11ee3 |
| institution | DOAJ |
| issn | 2500-0764 2542-0941 |
| language | Russian |
| publishDate | 2021-12-01 |
| publisher | Kemerovo State Medical University |
| record_format | Article |
| series | Фундаментальная и клиническая медицина |
| spelling | doaj-art-808e11fc861e4e5a8fe4192cf3f11ee32025-08-20T03:19:57ZrusKemerovo State Medical UniversityФундаментальная и клиническая медицина2500-07642542-09412021-12-0164224410.23946/2500-0764-2021-6-4-22-44286Risk factors for death in patients with severe COVID-19 admitted to an intensive care unitN. Yu. Osyaev0N. V. Ivannikova1G. V. Vavin2V. G. Moses3O. V. Gruzdeva4A. G. Kutikhin5Research Institute for Complex Issues of Cardiovascular Diseases; Belyaev Kuzbass Clinical HospitalBelyaev Kuzbass Clinical HospitalBelyaev Kuzbass Clinical HospitalBelyaev Kuzbass Clinical HospitalResearch Institute for Complex Issues of Cardiovascular DiseasesResearch Institute for Complex Issues of Cardiovascular DiseasesAim. Severe COVID-19 is accompanied by reduced blood oxygen saturation, systemic inflammatory response syndrome and multiple organ failure, all causing a significant deterioration of homeostasis associated with death. Here we aimed to study the risk factors for death in patients with severe COVID-19 who have been admitted to an intensive care unit.Materials and Methods. The study included 144 consecutive patients with severe COVID-19 who have been admitted to an intensive care unit of Kuzbass Clinical Hospital from August to December 2020. Groups of survivors and non-survivors were equal in number (n = 72) and matched by gender (36 men and women) and age (median age 64 years, interquartile range 56-70 years in survivors and 58-69 years in non-survivors). Complete blood count, urinalysis, biochemical analysis, coagulation testing, and measurement of anti-SARS-CoV-2 IgM/IgG were carried out in all patients immediately upon the admission to intensive care unit.Results. Risk factors for death in severe COVID-19 at the admission to intensive care unit were arterial hypertension, chronic heart failure, peripheral atherosclerosis, impaired renal homeostasis (reduced glomerular filtration rate, elevated serum creatinine and urea, proteinuria, hematuria), augmented fasting blood glucose and lactate, neutrophilia (in men), lymphopenia and increased neutrophil-to-lymphocyte ratio (in women), and decreased IgM/IgG to SARS-CoV-2 (in women).Conclusion. We found both independent and gender-specific risk factors for death due to COVID-19.https://fcm.kemsmu.ru/jour/article/view/465covid-19sars-cov-2adverse outcomedeathrisk factorshomeostasisintensive care unit |
| spellingShingle | N. Yu. Osyaev N. V. Ivannikova G. V. Vavin V. G. Moses O. V. Gruzdeva A. G. Kutikhin Risk factors for death in patients with severe COVID-19 admitted to an intensive care unit Фундаментальная и клиническая медицина covid-19 sars-cov-2 adverse outcome death risk factors homeostasis intensive care unit |
| title | Risk factors for death in patients with severe COVID-19 admitted to an intensive care unit |
| title_full | Risk factors for death in patients with severe COVID-19 admitted to an intensive care unit |
| title_fullStr | Risk factors for death in patients with severe COVID-19 admitted to an intensive care unit |
| title_full_unstemmed | Risk factors for death in patients with severe COVID-19 admitted to an intensive care unit |
| title_short | Risk factors for death in patients with severe COVID-19 admitted to an intensive care unit |
| title_sort | risk factors for death in patients with severe covid 19 admitted to an intensive care unit |
| topic | covid-19 sars-cov-2 adverse outcome death risk factors homeostasis intensive care unit |
| url | https://fcm.kemsmu.ru/jour/article/view/465 |
| work_keys_str_mv | AT nyuosyaev riskfactorsfordeathinpatientswithseverecovid19admittedtoanintensivecareunit AT nvivannikova riskfactorsfordeathinpatientswithseverecovid19admittedtoanintensivecareunit AT gvvavin riskfactorsfordeathinpatientswithseverecovid19admittedtoanintensivecareunit AT vgmoses riskfactorsfordeathinpatientswithseverecovid19admittedtoanintensivecareunit AT ovgruzdeva riskfactorsfordeathinpatientswithseverecovid19admittedtoanintensivecareunit AT agkutikhin riskfactorsfordeathinpatientswithseverecovid19admittedtoanintensivecareunit |