Biological factors controlling starch digestibility in human digestive system
Starch digestion rate and location in the gastrointestinal tract (GIT) are critical for human health. This review aims to present a comprehensive summary on our current understanding of physiological, biochemical, anatomical and geometrical factors of human digestive system that are related to in vi...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2023-03-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022001495 |
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| author | Cheng Li Yiming Hu Songnan Li Xueer Yi Shuaibo Shao Wenwen Yu Enpeng Li |
| author_facet | Cheng Li Yiming Hu Songnan Li Xueer Yi Shuaibo Shao Wenwen Yu Enpeng Li |
| author_sort | Cheng Li |
| collection | DOAJ |
| description | Starch digestion rate and location in the gastrointestinal tract (GIT) are critical for human health. This review aims to present a comprehensive summary on our current understanding of physiological, biochemical, anatomical and geometrical factors of human digestive system that are related to in vivo starch digestibility. It is shown that all digestive compartments including mouth, stomach, small intestine, and large intestine play critical roles in regulating the overall starch digestion process. A proper investigation of starch digestion pattern should thus be based on the consideration of all these compartments. Main biological factors are summarized as oral mastication and salivation, gastric emptying and motility, small intestinal enzymes and motility, large intestinal resistant starch (RS)-microbiota interactions and gut-brain feedback control, as well as glucose adsorption and hormonal feedback control. However, connections among these biological factors in determining starch digestive behaviors remain elusive. This is due to the inherent complexity of human GIT anatomy, motility and biochemical conditions, as well as ethical, financial and technical issues in conducting clinical studies. Much technological and scientific efforts from both clinical studies and in vitro simulation models are required for a better understanding of in vivo starch digestion behaviors. |
| format | Article |
| id | doaj-art-808c6973e669420590a426bd36684924 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-808c6973e669420590a426bd366849242025-02-03T06:55:49ZengTsinghua University PressFood Science and Human Wellness2213-45302023-03-01122351358Biological factors controlling starch digestibility in human digestive systemCheng Li0Yiming Hu1Songnan Li2Xueer Yi3Shuaibo Shao4Wenwen Yu5Enpeng Li6School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Institutes of Agricultural Science and Technology Development of Yangzhou University, Yangzhou 225009, China; Corresponding author at: School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200031, ChinaJoint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Institutes of Agricultural Science and Technology Development of Yangzhou University, Yangzhou 225009, ChinaSchool of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, ChinaSchool of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, ChinaDepartment of Food Science & Engineering, Jinan University, Guangzhou 510632, ChinaJiangsu Key Laboratory of Crop Genetics and Physiology/State Key Laboratory of Hybrid Rice, College of Agriculture, Yangzhou University, Yangzhou 225009, ChinaStarch digestion rate and location in the gastrointestinal tract (GIT) are critical for human health. This review aims to present a comprehensive summary on our current understanding of physiological, biochemical, anatomical and geometrical factors of human digestive system that are related to in vivo starch digestibility. It is shown that all digestive compartments including mouth, stomach, small intestine, and large intestine play critical roles in regulating the overall starch digestion process. A proper investigation of starch digestion pattern should thus be based on the consideration of all these compartments. Main biological factors are summarized as oral mastication and salivation, gastric emptying and motility, small intestinal enzymes and motility, large intestinal resistant starch (RS)-microbiota interactions and gut-brain feedback control, as well as glucose adsorption and hormonal feedback control. However, connections among these biological factors in determining starch digestive behaviors remain elusive. This is due to the inherent complexity of human GIT anatomy, motility and biochemical conditions, as well as ethical, financial and technical issues in conducting clinical studies. Much technological and scientific efforts from both clinical studies and in vitro simulation models are required for a better understanding of in vivo starch digestion behaviors.http://www.sciencedirect.com/science/article/pii/S2213453022001495Starch digestionHuman gastrointestinal tractBiological factorsGastric emptying rateGut microbiota |
| spellingShingle | Cheng Li Yiming Hu Songnan Li Xueer Yi Shuaibo Shao Wenwen Yu Enpeng Li Biological factors controlling starch digestibility in human digestive system Food Science and Human Wellness Starch digestion Human gastrointestinal tract Biological factors Gastric emptying rate Gut microbiota |
| title | Biological factors controlling starch digestibility in human digestive system |
| title_full | Biological factors controlling starch digestibility in human digestive system |
| title_fullStr | Biological factors controlling starch digestibility in human digestive system |
| title_full_unstemmed | Biological factors controlling starch digestibility in human digestive system |
| title_short | Biological factors controlling starch digestibility in human digestive system |
| title_sort | biological factors controlling starch digestibility in human digestive system |
| topic | Starch digestion Human gastrointestinal tract Biological factors Gastric emptying rate Gut microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022001495 |
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